GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 109-65-9
Chemical Name 1-Bromobutane
Substance ID H29-B-067
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2009  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
Based on a flash point of 13 deg C (closed cup), and a boiling point 102 deg C (GESTIS (Access on July 2017)), it was classified in Category 2. Besides, it is classified in Class 3, PGII in UNRTDG (UN 1126).
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 515 deg C (GESTIS (Access on July 2017)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - Based on reported LD50 values of 2,761 mg/kg (males) and 3,161 mg/kg (females) for rats (HSDB (Access on June 2017)), this substance was classified as "Not Classified" (Category 5 in UN GHS classification).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 4


Warning
H332 P304+P340
P261
P271
P312
Based on a reported LD50 value of 237 mg/L (42,291ppm) (converted 4-hour equivalent value: 83.8 mg/L (14,952 ppm)) in a 30-minute inhalation exposure test with mice (HSDB (Access on June 2017)), it was classified in Category 4. Besides, a reference value in the unit of ppm as vapour with little mist was applied because the exposure concentration was lower than 90% of the saturated vapour pressure concentration (55,392 ppm).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - There is a description that in a skin irritation test with mice, this substance is irritating to the skin (HSDB (Access on May 2017)), however, details of the test are unknown, and there is no other test data. Therefore, it was classified as "Classification not possible" due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - There is a description that in an eye irritation test with rabbits, this substance is irritating to the eye (HSDB (Access on May 2017)), however, details of the test are unknown, and there is no other test data. Therefore, it was classified as "Classification not possible" due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - There is a description that no skin sensitization was observed in a local lymph node proliferation test with mice (HSDB (Access on May 2017)), however, details of the test are unknown, and there is no other test data. Therefore, it was classified as "Classification not possible" due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There is no in vivo data, and as for in vitro, a bacterial reverse mutation test was positive (Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law (Access on July 2017)).
6 Carcinogenicity Category 2


Warning
H351 P308+P313
P201
P202
P280
P405
P501
In a carcinogenicity study in which rats and mice were exposed by inhalation for 2 years, there was no increase in tumor incidences associated with exposure in both males and females in rats (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, Access on May 2017)). In the test with mice, there was an increased incidence of bronchioloalveolar epithelial cancer in the lung in males, but no increase in the incidence of tumors was observed in females (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, Access on May 2017)). There are no classification results by other organizations. However, this substance was designated as a substance subject to "the Guidelines in order to prevent the impairment of worker's health caused by the chemical substances decided by the Minister of Health, Labour and Welfare based on paragraph (3) of Article 28 of the Industrial Safety and Health Act (hereinafter referred to as "Guidelines for Carcinogenicity")" in 2012. From the above, although this substance is subject to "Guidelines for Carcinogenicity" of the Ministry of Health, Labour and Welfare, since evidence of carcinogenicity in experimental animals is limited only to male mice, it was not classified in Category 1 but classified in Category 2 for this hazard class.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a report that as a result of repeated exposure in pregnant rats, a decrease in the survival rate of the fetuses and postnatal inhibition of development were observed, but the details were unknown (HSDB (Access on May 2017)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Classification not possible due to lack of data. The information described in the previous classification that labored breathing and ataxia were observed in a single oral dose test with rats (HSDB (2006)) is not described in HSDB (Access on May 2017). It cannot be confirmed, and there is no other information. Therefore, it was classified as "Classification not possible."
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory organs), Category 2 (haemal system, liver)


Danger
Warning
H372
H373
P260
P264
P270
P314
P501
No information on humans is available.
As for the experimental animals, in a 13-week inhalation toxicity test (6 hours/day, 5 days/week) with mice, eosinophilic change in the olfactory epithelium and basophilic change in the bronchioles at or above 31 ppm (converted guidance value: 0.12 mg/L), which is within the guidance value range for Category 1, eosinophilic change in the respiratory epithelium at or above 125 ppm (converted guidance value: 0.47 mg/L) which is within the guidance value range for Category 2, and anemia (decreases in red blood cell count, hemoglobin concentration, and hematocrit value), an increase in ALT (only 250 ppm), disarrangement in olfactory epithelium, hyperplasia and erosion of squamous epithelium in the forestomach, centrilobular necrosis, and enlargement of the nucleus in the hepatocytes were observed at or above 250 ppm (converted guidance value: 0.95 mg/L) (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, Access On May 2017)). In addition, in a 13-week inhalation toxicity test with rats and a 104-week inhalation toxicity test with mice, effects on the respiratory organs were observed within the guidance value range for Category 2, and in a 104-week inhalation toxicity test with rats, effects on the blood were observed within the guidance value range for Category 2 (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, Access On May 2017)).
Based on the above, it was classified in Category 1 (respiratory organs), and Category 2 (haemal system, liver).
Since the new information source was used, the classification result was different from the previous classification.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, the kinematic viscosity is calculated to be 0.478 mm2/sec (25 deg C) from the numerical data (viscosity: 0.606 mPa*s (25 deg C), density (specific gravity): 1.2686) listed in HSDB (Access on May 2017).

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - Reliable acute toxicity data were not obtained.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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