GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 108-93-0 |
| Chemical Name | Cyclohexanol |
| Substance ID | H29-B-070 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | There is the information that it is combustible (ICSC (J) (1998)), but the classification is not possible due to no data. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 300 deg C (ICSC (J) (1998)). |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not chlorine or fluorine) which are chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | It is a substance with a melting point of <= 55 deg C, but the classification is not possible due to no data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on a report of an LD50 value of 2,060 mg/kg for rats (ACGIH (7th, 2001)), it was classified as "Not classified" (Category 5 in UN GHS classification). According to the GHS classification guidance for the Japanese government, the category was changed from the previous classification. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Since the data of IUCLID (2000) used in the previous classification could not be obtained and could not be confirmed, it was not used. Therefore, the classification result was changed from the previous classification. Besides, there is a report of the minimum lethal dose value of 2,200-2,600 mg/kg for rabbits (PATTY (6th, 2012)), which exceeds the guidance value range for Category 4. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition). Besides, since the melting point is 25.93 deg C (HSDB (Access on June 2017)), it is considered to be a liquid at higher temperatures than that. |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - |
Solid (GHS definition). However, since the melting point is 25.93 deg C (HSDB (Access on June 2017)), it is considered to be a liquid at higher temperatures than this. There is a report of > 3.6 mg/L (> 882 ppm) as an LD50 value in a 4-hour inhalation exposure test with rats (HSDB (Access on June 2017)). However, because it is not possible to specify a category by this value alone, it was classified as "Classification not possible." Besides, since the exposure concentration is lower than 90% of the saturated vapor pressure concentration (1,287 ppm), a reference value in units of ppm was applied as vapor with little mist. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Category 2 |
 Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
Based on a description that it is slightly irritating to human skin (ACGIH (7th, 2001), PATTY (6th, 2012)), and a description that this substance is irritating to the skin in short term exposure (HSDB (Access on June 2017)), it was considered to be an irritant, therefore, it was classified in Category 2. Besides, this substance is classified as "Skin Irrit. 2, H315" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)). The category was changed by re-evaluating the contents of the information source. |
| 3 | Serious eye damage/eye irritation | Category 1 |
 Danger |
H318 |
P305+P351+P338
P280 P310 |
Based on a report that in a test in which this substance was applied to the eyes of rabbits (OECD TG 405 compliant), moderately severe irritation and reversible corneal injuries were observed (ACGIH (7th, 2001)), and a report that in another test with rabbits, the scores of corneal opacity in 4 animals after 4, 24, 48, 72 hours were all 3, and one animal did not recover from injury after 21 days (ECETOC TR48 (2) (1998)), it was classified in Category 1. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, though there is a report that no sensitization was observed in a human patch test (containing 4% of this substance in petrolatum) (PATTY (6th, 2012)), it was not adopted because the details of the test were unknown. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a mouse bone marrow micronucleus test was negative (PATTY (6th, 2012)). As for in vitro, bacterial reverse mutation tests were negative (ACGIH (7th, 2001), PATTY (6th, 2012), NTP DB (Access on July 2017)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Category 2 |
 Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
There is a description that after two strains of mice were dosed by feeding (0.1-1.0%) through the period of gestation and lactation over several generations, in both of the strains, a significant increase in mortality (14.1-53.5%) and slightly inhibited growth during 21 days after birth were observed at a high dose (1.0%) in the pups (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010), PATTY (6th, 2012)). Since effects on the next generation were observed in the situation where the general toxicity effects on parental animals were unknown, it was classified in Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
As for humans, there is a report that irritation of the nose and throat was observed by inhalation exposure to 100 ppm of this substance for 3-5 minutes in a volunteer study (OEL Documentations (Japan Society For Occupational Health (JSOH), 1970), PATTY (6th, 2012)). As for experimental animals, there is a report that in a single dermal exposure test with rabbits, although the doses were not described, the animals showed tremors, narcosis, and hypothermia and died in an application to extensive skin areas at high concentrations (PATTY (6th, 2012)). Therefore, it was classified in Category 3 (respiratory tract irritation, narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (autonomic nervous system), Category 2 (heart, liver, kidney, genetic organs (men)) |
Danger Warning |
H372
H373 |
P260
P264 P270 P314 P501 |
As for humans, there is a report that nonspecific disturbances in the autonomic nervous system were observed in 114 of 453 men and women who had been exposed at concentrations below the permitted level for 2 years, and similar symptoms were observed only in 8 people in the control group (100 people) (ACGIH (7th, 2001)). As for experimental animals, there is a report that in a 10-week inhalation toxicity test with rabbits, within the guidance value range for Category 2, slight degenerations were observed in the liver and kidney at 145 ppm (converted guidance value: 0.33 mg/L), and degenerations in the cardiac muscle, liver and kidney were observed at 272 ppm (converted guidance value: 0.62 mg/L) (PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)). In addition, there is a report that in a 40-day repeated oral dose toxicity test with male rabbits, decreases in the testes and testes weight, inhibition of spermatogenesis, decreases in the diameter of the seminiferous tubules and the volume of the Leydig cell nucleus, sperm deficiency in the lumen of the epididymis and vas deferens, etc. were observed at 25 mg/kg/day (converted guidance value: 11.1 mg/kg/day) within the guidance value range for Category 2 (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)). This was a test with one dose and effects at doses lower than this were unknown, however, the effects were observed in the testes within the guidance value range for Category 2. From the above, it was classified in Category 1 (autonomic nervous system) and Category 2 (heart, liver, kidney, genetic organs (men)). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 |
P273
P501 |
From 48-hour EC50 = 17 mg/L for crustacea (Daphnia magna) (NLM HSDB: 2011), it was classified in Category 3. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 3 |
- |
H412 |
P273
P501 |
Chronic toxicity data were not obtained. Due to being rapidly degradable (readily biodegradable, average degradation rate by BOD: 96% (J-CHECK, 1988)), no bioaccumulation (LogKow: 1.23 (SRC PhysProp Database: 2017)), and acute toxicity Category 3, it was classified in Category 3. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |