GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 16872-11-0 |
| Chemical Name | Borofluoric acid |
| Substance ID | H29-B-093 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on August 2017)). |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on August 2017)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on August 2017)). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains metalloids (B), but it is estimated that it does not react vigorously with water from the observation result of being very soluble in water (HSDB (Access on August)). |
| 13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an inorganic compound containing halogen (F) (but not oxygen), but the classification is not possible due to no data. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Category 1 |
 Warning |
H290 |
P234
P390 P406 |
Based on the information that it is a strong acid and attacks many metals (HSDB (Access on August 2017)), it was classified in Category 1. Besides, it is classified in Class 8, PGII in UNRTDG (UN 1775). |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 3 |
 Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
Based on the reported LD50 values of 100-200 mg/kg (HSDB (Access on August 2017)) for rats, this substance was classified in Category 3. |
| 1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 |
P302+P352
P361+P364 P280 P312 P321 P405 P501 |
There are reports on LD50 values of 2.5-5.0 mL/kg (converted value: 3,450-6,900 mg/kg, converted 100% equivalent value from purity 21.7%: 749-1,498 mg/kg) (HSDB (Access on August 2017)) for guinea pigs, and these correspond to Category 3-4. It was classified in Category 3 by adopting the category with higher hazard. The classification result was changed from the previous classification. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Since it is described that it has strong caustic action on human skin and causes burns (HSDB (Access on August 2017)), it was classified in Category 1. Besides, this substance was classified as "Skin Corr. 1B" in EU CLP classification (ECHA CL Inventory (Access on August 2017)). |
| 3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
It is classified in Category 1 for skin corrosion/irritation. There is a description that it is irritating to human eyes (HSDB (Access on August 2017)). Therefore, this substance was classified in Category 1. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. There is no in vivo data on this substance. As for in vitro, a bacterial reverse mutation test was negative (HSDB (Access on August 2017)). Besides, for the genotoxicity of fluorine, it is stated by the Food Safety Commission of Japan that in in-vitro tests with mammalian cells, weak positive results were obtained, but in an in-vivo DNA damage test, it was judged negative in a comprehensive manner, and it is considered that there is no genotoxicity which is a particular problem for living bodies (Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2012)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Fluorides are classified in A4 by ACGIH (ACGIH (7th, 2001)). Therefore, it was classified as "Classification not possible." |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects) |
  Warning |
H371
H335 H336 |
P308+P311
P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
There is description that this substance is irritating to the respiratory tract (HSDB (Access on August 2017)). As for experimental animals, there is a report that in a single oral dose test with rats, dyspnea, sedation and lack of appetite were found at 100 mg/kg, and at 464 mg/kg, in addition to these symptoms, hyporeflexia, ataxia, tremors, reduced muscle tone, squatting position, and reduced locomotor activity were observed. It is reported that all the animals survived and also in autopsy, no abnormal findings were observed. However, it is reported that all the animals died within 24 hours at 1,000 mg/kg and on autopsy, edema and hemorrhage in the gastrointestinal tract wall, and hemorrhage in the liver were observed (HSDB (Access on August 2017)). From the above, this substance was classified in Category 2 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects). In the previous classification, it was classified in Category 2 (respiratory system) based on the description that this substance is corrosive to the airways and may cause pulmonary edemas (ICSC (J) (1995), SITTIG (4th, 2002), HSFS (1999)). However, it was not adopted as evidence of classification since the information sources are materials listed in List 3 and there is no other information providing the rationale for the classification. Therefore, the classification result was changed. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (teeth, bone) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
In humans, there is no information on this substance. However, there is a report of lesions in bones related to fluorosis due to occupational exposure to inorganic fluoride in ACGIH's "FLUORIDES" (ACGIH (7th, 2001)). In addition, for fluorides, both beneficial and detrimental dental and skeletal effects have been observed in humans. Fluoride has been shown to decrease the prevalence of dental caries and, under certain conditions, has been used for the treatment of osteoporosis. However, it is described that excess fluoride can also result in dental fluorosis and can result in an increased prevalence of bone fractures in the elderly or patients with skeletal fluorosis (ATSDR (2003)). As for experimental animals, there is no information on this substance. Therefore, this substance was classified in Category 1 (bone, teeth). Besides, since new sources of information were used, the classification result differed from the previous classification. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |