GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 97-86-9 |
| Chemical Name | Isobutyl methacrylate |
| Substance ID | H29-B-098 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2008 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
 Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of 35 deg C (closed cup) (HSDB (Access on August 2017)), it was classified in Category 3. Besides, stabilized one is classified in Class 3, PGIII in UNRTDG (UN 2283). |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (ethylene group) in the molecule, but because stabilized one is classified in Class 3, PGIII in UNRTDG (UN 2283), it does not correspond to self-reactive substances and mixtures, hazard class with the highest precedence. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 385 deg C (GESTIS (Access on August 2017)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on reports of LD50 values of 6,400-12,800 mg/kg (ECETOC JACC (1996)) and 9,590 mg/kg (SIDS (2009)) for rats, this substance was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a report of an LD50 value of > 17,760 mg/kg (PATTY (6th, 2012), SIDS Dossier (2009), HSDB (Access on August 2017)) for guinea pigs, this substance was classified as "Not classified." |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | It is reported that an LC50 value in a 6-hour inhalation exposure test with rats was > 3,600 ppm (converted 4-hour equivalent value: > 4,409 ppm) (ECETOC JACC 36 (1996)), and it corresponds to Category 4 or "Not classified." However, it was classified as "Classification not possible" since it was not possible to identify the category from this value alone. Besides, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (4,791 ppm (27.84 mg/L)), a reference value in the unit of ppm was applied as vapour with little mist. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on a report that the LC50 value in a 290-min (4.83-hour) inhalation exposure test with mice is 5,026 ppm (29.74 mg/L) (converted 4-hour equivalent value: 5,523 ppm (32.68 mg/L)) (SIDS (2009), HSDB (Access on August 2017)), this substance was classified as "Not classified." Besides, the exposure concentration was higher than the saturated vapor pressure concentration (4,791 ppm (27.84 mg/L)), so the reference value in the unit of mg/L was applied as mist. The classification result was changed from the previous classification because the new information sources were used. |
| 2 | Skin corrosion/irritation | Category 2 |
 Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
There is a description that in a skin irritation test with rabbits, when this substance was applied for 2 hours, mild irritation was seen at a primary skin irritation index of 1.87 (SIDS (2009)). In addition, it was described that in two tests in which this substance was applied to rabbits for 24 hours, it was moderately irritating at a primary skin irritation index of 4.16, and it was slightly irritating at a primary skin irritation index of 1.83 (both ECETOC JACC (1996), SIDS (2009)). Since it was considered that this substance was irritating from these results, this substance was classified in Category 2. Besides, this substance was classified as "Skin Irrit. 2, H315" in the EU CLP classification (ECHA CL Inventory (Access on August 2017)). |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 |
P305+P351+P338
P337+P313 P264 |
There are descriptions that in an eye irritation test (OECD TG 405 compliant) with rabbits, one animal exhibited slight conjunctival redness, edema and discharge, but the redness resolved after 24 hours as did other irritation findings after 48 hours, and the remaining animals showed no irritation. Also, it is described that there was no primary irritation index (SIDS (2009)). In addition, there are reports that in other multiple eye irritation tests with rabbits, slight irritation was observed (ECETOC JACC (1996), SIDS (2009)). Based on these results, it was considered to have slight irritancy, and was classified in Category 2B. Besides, this substance was classified as "Eye Irrit. 2, H319" in the EU CLP classification (ECHA CL Inventory (Access on August 2017)). The classification was changed based on the information obtained in this research. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | There are descriptions of negative in a skin sensitization test (maximization test) with guinea pigs (ECETOC JACC (1996), SIDS (2009)), and negative in another skin sensitization test (Steven's ear/Flank test) using guinea pigs (SIDS (2009)). On the other hand, there is a report that in a skin sensitization test (LLNA assay, OECD TG 429 compliant), this substance was positive with its SI value of 5.13 (it is positive at or above 3.) (ECHA registration dossier (Access on November 2017)). No useful information was available in humans. Because there were both positive and negative results, it was classified as "Classification not possible." Besides, this substance was classified as "Skin Sens. 1, H317" in the EU CLP classification (ECHA CL Inventory (Access on August 2017)). |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Since it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible." As for in vivo, a micronucleus test with mouse bone marrow cells was negative (SIDS (2009)). As for in vitro, a bacterial reverse mutation test was negative (SIDS (2009), NTP DB (Access on August 2017)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | As a result of intraperitoneal administration of this substance at doses of 10 to 33% of the LD50 value on Gestational Days 5, 10 and 15 in pregnant rats, fetal skeletal abnormality, fetal death, embryo/fetal absorption were observed. Regarding the above findings, it was pointed out that since the administration route was intraperitoneal, it had no indirect influence via the maternal body but it might have a direct action on the fetuses (PATTY (6th, 2012)), therefore, considering the administration route, it was not used for the classification. Because there is no other available data for the classification, this substance was classified as "Classification not possible" due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
There is no single-exposure information on this substance in humans. As for experimental animals, in single inhalation exposure tests with rats and mice with this substance or n-butyl methacrylate (CAS RN 97-88-1), there is no detailed description of the dose where symptoms were observed, but there is a report that as a symptom common to both substances, lung noise, irregular respiration, and nasal discharge were observed, and it is described that it is thought to be due to exposure to substances irritant to the respiratory tract (ECETOC JACC (1996)). In the oral route, there is a report that in a single oral dose test with rats, hypoactivity, staggering gait, ataxia, decreased muscle tone of extremities and abdomen, diarrhea, piloerection, and decreased body temperature were observed (SIDS Dossier (2009)). However, it was not adopted as evidence of the classification since the minimal dose of the test was 8,880 mg/kg, above the Category 2 and there is no information on the dose below that. Therefore, this substance was classified in Category 3 (respiratory tract irritation). Besides, IUCLID (2000) used for the previous classification could not be confirmed because it was not available. The classification result was changed from the previous classification due to use of the new information sources. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 |
P273
P501 |
From 72-hour EC50 (rate method) = 16 mg/L for algae (Pseudokirchneriella subcapitata) (OECD SIDS: 2004), it was classified in Category 3. |
| 11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Due to being rapidly degradable (readily biodegradable, judged by comparison with degradability of the related compounds (J-CHECK, 2012)), no bioaccumulation (LogKow: 2.66 (SRC PhysProp Database: 2017)), and 72-hour NOEC (rate method) = 5.8 mg/L for algae (Pseudokirchneriella subcapitata) (OECD SIDS: 2004), it was classified as "Not classified." |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |