GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 108-18-9 |
| Chemical Name | Diisopropylamine |
| Substance ID | H29-B-118 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
 Danger |
H225 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of -7 deg C (closed cup), and a boiling point of 82 deg C (GESTIS (Access on September 2017)), it was classified in Category 2. Besides, it is classified in Cass 3, Subsidiary risk 8, PGII in UNRTDG (UN 1158). |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 285 deg C (GESTIS (Access on September 2017)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
Based on a report of an LD50 value of 770 mg/kg for rats (ACGIH (7th, 2001), PATTY (6th, 2012)), this substance was classified in Category 4. |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - |
There is a reported LD50 value of > 10,000 mg/kg for rabbits (ChemID (Access on January 2018)), and it corresponds to "Not classified." There is a reported LD50 value of > 2,000 mg/kg for rats or rabbits (it was unknown which of animal species was used, but described as a test equivalent to OECD TG 402) (SIAP (2013)), and it corresponds to "Not classified." From the above, this substance was classified as "Not classified." |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
 Danger |
H331 |
P304+P340
P403+P233 P261 P271 P311 P321 P405 P501 |
Based on a reported LC50 value of 4.8 mg/L (1,162 ppm) (converted 4-hour equivalent value: 3.4 mg/L (821 ppm)) (HSDB (Access on August 2017)) in a 2-hour inhalation exposure test with rats, this substance was classified in Category 3. Besides, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (104,792 ppm), a reference value in the unit of ppm was applied as vapour with little mist. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Category 1A |
 Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In a skin irritation test with rabbits (OECD TG 404 compliant), clear evidence of necrosis (discoloration to reddish brown and greenish brown at the application site) was observed within 24 hours after the 3-minute application of this substance. This was followed by drying and roughening, resulting in desquamation and open wounds, and becoming scarred. There is a description that the skin tissue showed irreversible damage in all its layers (ECHA registration information (Access on December 2017)). In addition, there is a description that alkylamines including this substance cause strong skin irritation and corrosivity (SIAP (2013)) and a description that the pH of this substance was 12.5 (HSDB (Access on August 2017)). Therefore, it was classified in Category 1A. Besides, in EU CLP classification, this substance is classified as "Skin Corr. 1B, H314" (ECHA CL Inventory (Access on August 2017)). |
| 3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
This substance was classified in Category 1A for skin corrosion/irritation. In eye irritation tests with rabbits (OECD TG 405 compliant), the ocular disorders did not resolve within the observation period of 8 days, and although, without data on Day 21, the irreversibility of the disorder is unclear, this substance caused disorders of the cornea, iris and conjunctiva, and was reported as corrosive (ECHA registration information (Access on December 2017)). In addition, there is a description that alkylamines including this substance cause eye irritation and furthermore, may have corrosivity (SIAP (2013)). Therefore, this substance was classified in Category 1. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is a description that in a skin sensitization test with guinea pigs (OECD TG 406 compliant), skin sensitization was not observed for this substance (ECHA registration information (Access on December 2017)), but since no information on other animal tests and humans was available, this substance was classified as "Classification not possible." |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is no in vivo data. As for in vitro, a bacterial reverse mutation test was negative (NTP DB (Access on September 2017), HSDB (Access on August 2017)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. In addition, there was a report that as a result of inhalation exposure in rats for 1 month, atrophy and decreased secretion in seminal vesicles and increased relative testes weights were observed at a concentration of 2.0 mg/L at which various effects such as corrosivity were present (SIAP (2013)). |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
 Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
In humans there is a description that this substance is a severe pulmonary irritant (PATTY (6th, 2012)). In addition, there is a report that workers who were exposed by inhalation at 25-50 ppm of this substance complained of disturbances of vision, nausea and headaches (ACGIH (7th, 2001), PATTY (6th, 2012)). As for experimental animals, it is reported that in tests with several animal species (although no details are described, there is a possibility the species were rabbits, guinea pigs, rats and cats from the description in other citations of the same reference), lacrimation, corneal clouding and severe irritation of the respiratory tract were observed in inhalation exposure at 2,207 ppm for 3 hours, and at autopsy, pulmonary edema and hemorrhage were observed (PATTY (6th, 2012)). The converted 4-hour equivalent value of the dose at which the effect was observed in animals is 1,911ppm (7.9 mg/L), which corresponds to Category 1. Based on the above information on humans and animals, the target organ of this substance was considered to be the respiratory organs. Therefore, it was classified in Category 1 (respiratory organs). As for disturbances of vision in humans, since this substance was classified in Category 1 for serious eye damage/eye irritation class, it is not adopted as evidence. Since information of nausea and headache in humans was insufficient as evidence for the classification, it was not adopted. Although it was classified in Category 2 (respiratory system) in the previous classification, since PATTY and ACGIH are the information sources listed in List 1, the category was changed from the previous classification. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, this substance is a strong alkaline liquid (PATTY (6th, 2012)), in humans there is a report that at an average concentration of 25-50 ppm, it caused visual disturbance (haziness or halos around lights), nausea and headaches to workers (ACGIH (7th, 2001), PATTY (6th, 2012)). In addition, there is a report that in tests in which rats, rabbits, guinea pigs and cats were exposed by inhalation at 600 ppm for 8 weeks (7 hours/day, 40 times), there were corneal opacity due to irritation accompanied with partial or total loss of vision, and death of rabbits and guinea pigs (ACGIH (7th, 2001)). Since these effects on the eyes were classified in Category 1 for serious eye damage/eye irritation, they were not adopted. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, the kinematic viscosity was calculated as 0.56 mm2/sec (25/20 deg C) by numerical data (viscosity: 0.40 mPa*s (25 deg C), density (specific gravity): 0.7169 (20/4 deg C)) listed in HSDB (Access on August 2017). |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 1 |
 Warning |
H400 |
P273
P391 P501 |
From 72-hour EC50 = 0.21 mg/L for algae (Oscillatoria agardhii) (EPA AQUIRE: 2017, Hanstveit, A. O. et al. (1985)), it was classified in Category 1. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (BIOWIN), 35-day NOEC (survival rate) = 187 mg/L for fish (Gasterosteus aculeatus) (EPA AQUIRE: 2017, Van den Dikkenberg, R. P. et al. (1989)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN), and 72-hour EC50 = 0.21 mg/L for algae (Oscillatoria agardhii) (EPA AQUIRE: 2017, Hanstveit, A. O. et al. (1985)). By drawing a comparison between the above results, it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |