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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	563-04-2
Chemical Name	Tri-3-tolyl phosphate (m-Tricresyl phosphate)
Substance ID	H30-A-002-METI, MOE
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	There is a metalloid (P) present in the molecule. However, because there is an observation result that it is insoluble in water (GESTIS (Accessed Sept. 2018)), it is estimated that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	[Rationale for the Classification] There are no data in rodents including rats. Therefore, classification was not possible due to lack of data. [Reference Data, etc.] (1) LD50 for rabbits: > 3,000 mg/kg (EHC 110 (1990), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	[Rationale for the Classification] Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. Besides, there is (1), but the details are unknown. [Reference Data, etc.] (1) It was reported that skin irritation in guinea pigs was mild for this substance, moderate for the o-isomer (CAS RN 78-30-8) and p-isomer (CAS RN 78-32-0), and there was no irritation for an isomer mixture (CAS RN 1330-78-5) (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)).
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. Besides, there is a report in (1), but the details are unknown. [Reference Data, etc.] (1) There is a description that this substance may cause eye irritation if it turns into a vapor under high temperature environment (HSDB (2013)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) There is a report that in a patch test on a person (67-year-old woman) who developed dermatitis, a positive reaction was observed with a 0.5% solution of this substance, but no reaction was observed with a 5% solution of the p-isomer (CAS RN 78-32-0) (HSDB (2013), Carlsen L, et al. (1986)).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] There are no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, the result of a bacterial reverse mutation test was negative (NTP DB (Accessed Sept. 2018)).
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] As for carcinogenicity, there are no available reports on humans. There are no classification results by domestic and international organizations, and in experimental animals, there is also no test report using this substance of a high purity. Therefore, it was classified as "Classification not possible" due to lack of data. Besides, in carcinogenicity studies in which an isomer mixture was administered by feeding to rats and mice for 2 years in (1), no evidence of carcinogenicity was observed in either sex in either species. [Reference Data, etc.] (1) In carcinogenicity tests in which as a test substance, an isomer mixture of a purity of 79% (tricresyl phosphate (CAS RN 1330-78-5)) containing 21% of this substance, 4% of the p-isomer and less than 1% of the o-isomer was administered by feeding to rats and mice for 2 years, no evidence of carcinogenicity was observed in either sex in either species (NTP TR433 (1994), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)).
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (1), isomer mixtures were classified in Category 1B (GHS Classification Result in FY 2008), but there is no test report using this substance of a high purity. Therefore, classification was not possible due to lack of data. [Reference Data, etc.] (1) There is a report that in a two generation test with mice by continuous breeding using an isomer mixture of a purity of 79% (tricresyl phosphate (CAS RN 1330-78-5)) containing 21% of this substance, 4% of the p-isomer, and less than 1% of the o-isomer as a test substance, in the F0 generation, a decrease in the number of births and an effect on the sperms (decreased sperm count and motility, morphological abnormalities), and also in the F1 generation, a decrease in the pregnancy rate, the number of live births and a decrease in sperm motility were observed (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)).
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Based on the data in (1) and (2), although the o-isomer is a neurotoxic substance, as for the m-isomer, which is this substance, human and experimental animal data from which neurotoxicity were suspected, could not be obtained. Other than these, there are no data with which target organs can be identified other than the nervous system. Therefore, it was classified as "Classification not possible" for this hazard class. [Reference Data] (1) As described in Environmental Risk Assessment for Chemical Substances (Ministry of the Environment) for tricresyl phosphate (CAS RN 1330-78-5), it is stated that the neurotoxicity from ingestion of edible oils and occupational exposure is due to o-isomer (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). (2) There is a description that the intensity of toxicity and neurotoxicity in humans is strong in the order of the p-isomer < m-isomer < o-isomer among the 3 isomers, and oral lethal doses for adults are 1-10 g for the o-isomer, while the m-isomer and p-isomer are practically nontoxic and do not cause demyelination of the nerves (PATTY (6th, 2012)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] There is no information available for classification on the effects of this substance in humans, including effects on the nervous system. There is no test report using this substance of a high purity also in animals. Therefore, classification was not possible due to lack of data. Besides, neither of (1) nor (2) can be said to be effects of administration of this substance and can be used for the classification. [Reference Data, etc.] (1) There is a report that in a study in which tricresyl phosphate (TCP (CAS RN1330-78-5)) consisting of composition ratio of 60-65% of this substance and 30-35% of the p-isomer as a test substance was administered by gavage to rats for 90 days, hematological changes suggestive of anemia were observed in females within the range of Category 2 (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). (2) There are reports that in studies in which TCP of a purity of 78% consisting of 21% of this substance, 4% of the p-isomer and less than 1% of the o-isomer as a test substance was administered by feeding to rats and mice for 13 weeks and 2 years, changes of the adrenal cortex (cytoplasmic vacuolization, etc.) were observed at doses within the range of Category 2 (NTP TR433 (1994)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	Reliable acute toxicity data were not obtained.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	Reliable chronic toxicity data were not obtained. Although it is not rapidly degradable (not readily degradable, an average degradation rate by BOD: 37% (J-CHECK, 1975)), because reliable acute toxicity data were not obtained, it was classified as "Classification not possible."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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