Item | Information |
---|---|
CAS RN | 107-19-7 |
Chemical Name | 2-Propyn-1-ol |
Substance ID | H30-B-005-MHLW, MOE |
Classification year (FY) | FY2018 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (acetylenes) present in the molecule, but the classification is not possible due to no data. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 3 |
Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point is 33 deg C (closed cup) (ICSC (1997)). |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (acetylenes) present in the molecule, but the classification is not possible due to no data. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 365 deg C (GESTIS (Accessed Jul. 2018)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
[Rationale for the Classification] Based on (1)-(4), 2 cases correspond to Category 2-Category 3 and 6 cases to Category 3. Therefore, it was classified in Category 3 adopting the category with the larger number of cases. Since new information sources were used and the GHS classification guidance for the Japanese Government was revised from the previous classification, the category was changed. [Evidence Data] (1) LD50 values for rats: 93 mg/kg (male), 55 mg/kg (female) (PATTY (6th, 2012), NTP TR552 (2008), ACGIH (7th, 2001)) (2) LD50 values for rats: 110 mg/kg (male), 54 mg/kg (female) (PATTY (6th, 2012), NTP TR552 (2008)) (3) LD50 values for rats: 20-50 mg/kg, 56 mg/kg, 70 mg/kg (PATTY (6th, 2012)) (4) LD50 values for rats: 35-110 mg/kg (MAK/BAT (2005)) |
1 | Acute toxicity (Dermal) | Category 1 |
Danger |
H310 |
P302+P352
P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
[Rationale for the Classification] Based on (1)-(3), one case corresponds to Category 1, one case to Category 1-Category 2 and one case to Category 2. Therefore, the category with the higher hazard was adopted, and it was classified in Category 1. [Evidence Data] (1) LD50 value for rabbits: 16 mg/kg (PATTY (6th, 2012), NTP TR552 (2008)) (2) LD50 value for rabbits: 88 mg/kg (PATTY (6th, 2012), NTP TR552 (2008)) (3) LD50 values for rabbits: 16-190 mg/kg (MAK/BAT (2005)) |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - |
[Rationale for the Classification] Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
Danger |
H331 |
P304+P340
P403+P233 P261 P271 P311 P321 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 3. Besides, the exposure concentration was lower than 90% of the saturated vapor concentration (15,198 ppm), so the reference values in units of ppm were applied as a vapor with little mist. The category was changed from the previous classification by use of the new information sources. [Evidence Data] (1) LC50 value (2 hours) for rats: 2,000 mg/m3 (872 ppm) (converted 4-hour equivalent value: 617 ppm) (MAK/BAT (2005)) (2) LC50 values (one hour) for rats: 1,040-1,200 ppm (converted 4-hour equivalent value: 520-600 ppm) (PATTY (6th, 2012), NTP TR552 (2008), ACGIH (7th, 2001)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 1B |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1B. [Evidence Data] (1) There are reports that in two skin irritation tests with rabbits, irritation and superficial necrosis after application of this substance itself and mild irritation after application of a 10% solution were observed (PATTY (6th, 2012), ACGIH (7th, 2001)). (2) There is a report that in a skin irritation test (test method equivalent to OECD TG404) with rabbits, in the case of 1-minute application, slight necrosis was observed after 8 days and in the case of application for 5 or 15 minutes, severe necrosis was observed after 8 days (BUA 213 (1999), REACH registration dossier (Accessed Jul. 2018)). [Reference Data, etc.] (3) This substance was classified as "Skin Irrit. 1B" in EU CLP. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
[Rationale for the Classification] Although there are information (1) indicating eye damage and information (2) indicating irritation, by giving priority to the former, it was classified in Category 1. [Evidence Data] (1) There is a report that in an eye irritation test with rabbits, after application of the undiluted liquid of this substance, marked pain and irritation occurred, and corneal damage was irreversible (PATTY (6th, 2012)). [Reference Data, etc.] (2) There is a report that in an eye irritation test with rabbits, after application of a 10% solution of this substance, slight irritation occurred but this resolved within a few days (PATTY (6th, 2012)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - |
[Rationale for the Classification] Although information (1) indicating that this substance is not a skin sensitizer was obtained, the details of the test are unknown and adequate evidence to judge as "Not classified" is not obtained. Therefore, it was classified as "Classification not possible." Besides, by reviewing the weight of evidence, the category was changed from the previous classification. [Reference Data, etc.] (1) There is a report that as a result of skin sensitization test with guinea pigs, no skin sensitization was shown (ACGIH (7th, 2001), PATTY (6th, 2012)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
[Rationale for the Classification] Based on (1) and (2), it was classified as "Classification not possible" in accordance with the GHS Classification Guidance for the Japanese Government. Besides, information sources different from the previous classification were added and reviewed, and the classification result was changed. [Evidence Data] (1) As for in vivo, negative (male) or equivocal (female) results were found in a micronucleus test with mouse peripheral blood by inhalation exposure (NTP TR552 (2008), PATTY (6th, 2012)), and a negative result was obtained in a micronucleus test with mouse bone marrow by oral administration (PATTY (6th, 2012), MAK/BAT (2005)). (2) As for in vitro, negative or positive results in bacterial reverse mutation tests (NTP TR552 (2008), PATTY (6th, 2012)) and a positive result in a mammalian cell chromosome aberration test (PATTY (6th, 2012), MAK/BAT (2005)) were obtained. |
6 | Carcinogenicity | Category 2 |
Warning |
H351 |
P308+P313
P201 P202 P280 P405 P501 |
[Rationale for the Classification] As for carcinogenicity, there are no available reports on humans. According to (1) and (2), since the tumors observed in two species of experimental animals were mostly benign tumors, it was classified in Category 2. Besides, the classification result was reviewed using new information sources, and the category was assigned. [Evidence Data] (1) In a carcinogenicity study in which rats were exposed by inhalation to the vapor of this substance for 2 years, in males in the high dose (64 ppm) group, nasal respiratory epithelial adenomas were observed in 3/50 animals, and the incidence is higher than the range in historical control data. In addition, an increased incidence of mononuclear leukemia is reported in males in the same group (NTP TR552 (2008), PATTY (6th, 2012)). (2) In a carcinogenicity study in which mice were exposed by inhalation to the vapor of this substance for 2 years, the incidence of nasal respiratory epithelial adenomas tended to increase in both sexes, and a significant increase was observed in the high dose (32 ppm) group (NTP TR552 (2008), PATTY (6th, 2012)). In addition, an increased incidence of Harderian gland adenoma was observed in males in the high dose (NTP TR552 (2008)). (3) The NTP concluded that there is some evidence of carcinogenicity of this substance in male rats and male and female mice (NTP TR552 (2008)). (4) There are no classification results by domestic and international organizations. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 3 (respiratory tract irritation). Besides, information sources different from the previous classification were added and reviewed, and the classification result was changed since the target organ is considered to be the respiratory tract. [Evidence Data] (1) There is a description that this substance is irritating to the respiratory tract (NTP TR552 (2008), PATTY (6th, 2012)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs, liver, kidney) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1)-(5), the liver and the kidney are considered as target organs through the oral and inhalation routes, and through the inhalation route, the respiratory organs are also considered as target organs in (3)-(5), and all effects were found within the dose range of Category 1. Therefore, it was classified in Category 1 (respiratory organs, liver, kidney). Besides, information sources different from the previous classification were added and reviewed, and the respiratory organs were added as a target organ. [Evidence Data] (1) In a study with rats dosed by gavage for 28 days, at or above 45 mg/kg/day (converted guidance value: 15 mg/kg/day, within the range of Category 2), hepatocyte damage (hypertrophy, vacuolation, etc. of the nucleus), increases in GPT, alkaline phosphatase, glutamate dehydrogenase activity, and inhibition of cholinesterase activity were observed (Environmental Risk Assessment for Chemical Substances Vol.6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)). (2) In a study with rats dosed by gavage for 13 weeks, at 15 mg/kg/day (within the range of Category 2), effects on the liver (increased liver weight, hepatocellular vacuolization, bile duct proliferation, megalocytosis) and effects on the kidney (increased kidney weight, karyomegaly of renal tubular epithelial cells) were observed (Environmental Risk Assessment for Chemical Substances Vol.6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008), PATTY (6th, 2012), IRIS (1990)). (3) As for the inhalation route, in a study in which rats were exposed by inhalation to the vapor of this substance over 3 months (7 hours/day, 5 days/week, 59 days of administration), at 80 ppm (converted guidance value: 0.14 mg/L, within the range of Category 1), in the liver and the kidney, degenerative changes were observed in addition to increased weight (ACGIH (7th, 2001), PATTY (6th, 2012)). (4) In studies in which rats or mice were exposed by inhalation to the vapor of this substance for 14 weeks (6 hours/day, 5 days/week), at 16-64 ppm (converted guidance value: 0.03-0.12 mg/L, within the range of Category 1), in the nasal cavity of rats, hyperplasia and squamous metaplasia of the respiratory epithelium and necrosis of the olfactory epithelium were observed. In addition, in mice, suppurative inflammation in the nasal cavity, squamous metaplasia and hyaline degeneration of the respiratory epithelium, atrophy, necrosis, and glandular tissue hyperplasia of the olfactory epithelium, and atrophy of the nasal turbinate were observed (NTP TR552(2008), PATTY (6th, 2012)). (5) In studies with rats and mice exposed by inhalation for 2 years, in both species, similar changes as in the 13-week inhalation exposure tests were observed in the respiratory epithelium and olfactory epithelium of the nasal cavity at concentrations at or above 16 ppm in rats and at or above 8 ppm in mice (converted guidance value: 0.015-0.03 mg/L, within the range of Category 1) (NTP TR552 (2008), PATTY (6th, 2012)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
It was classified in Category 2 from 96-hour LC50 = 1.44 mg/L for fish (Pimephales promelas) (NLM HSDB: 2018, EPA AQUIRE: 2018, Geiger, D. L. et al. (1988)). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Chronic toxicity data were not obtained. It was classified as "Not classified" due to rapid degradability (readily biodegradable, an average degradation rate by BOD: 95% (J-CHECK, 2001)), and no bioaccumulation (LogKow: -0.38 (PHYSPROP Database: 2018)). |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
|