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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	10294-33-4
Chemical Name	Tribromoborane
Substance ID	H30-B-006-MHLW, MOE
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (ICSC (2001)).
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (ICSC (2001)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2001)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metalloid (B) and reacts with water (ICSC (2001)). However, a gas produced is hydrogen bromide and not a flammable gas.
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an inorganic compound containing halogen (Br) (but not oxygen), but the classification is not possible due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	[Rationale for the Classification] Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	[Rationale for the Classification] Though data on this substance were not reported, this substance reacts violently on contact with water to produce hydrogen bromide. It is considered that hydrogen bromide is produced in the body when the vapor of this substance is inhaled. Therefore, as a result of adopting the hydrogen bromide data from (1), it was classified in Category 3. [Evidence Data] (1) LC50 value (1 hour) of hydrogen bromide for rats: 2,860 ppm (converted 4-hour equivalent value: 1,430 ppm) (ACGIH (2004))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1. [Evidence Data] (1) Since this substance turns into hydrogen bromide upon contact with water, there is information that the solution of this substance is corrosive to humans and may cause burns (ACGIH (7th, 2001), HSDB (Accessed Jul. 2018)). [Reference Data, etc.] (2) This substance was classified as Skin Corr. 1A by EU CLP.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Evidence Data] (1) There is a report that this substance is corrosive and causes severe damage to the cornea and conjunctiva (HSDB (Accessed Jul. 2018)). (2) This substance was classified in Category 1 for skin corrosion/irritation.
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Because this substance is considered to be severely irritating/corrosive to the respiratory tract mucosa from (1)-(4), it was classified in Category 1 (respiratory organs). Besides, new information sources were added to the information sources used in the previous classification, the classification was reviewed, and the classification was changed. [Evidence Data] (1) Since this substance turns into hydrogen bromide upon contact with water, there is a report that inhalation may cause severe irritation to the respiratory tract (ACGIH (7th, 2001)). (2) There is a description that symptoms that can be caused by overexposure are dyspnea and pulmonary edema (HSDB (Accessed Jul. 2018)). (3) There is a report that toxic effects are thought to be those of hydrogen bromide, the decomposition product (PATTY (6th, 2012)). (4) There is a report that rats exposed to hydrogen bromide at 1,300 ppm for 30 minutes showed severe necrohemorrhagic rhinitis, necrosis of the mucosa and submucosa extending to the turbinate bone and hemorrhage (PATTY (6th, 2012)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, teeth)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1), it is considered that hydrogen bromide is produced in the body when the vapor of this substance is inhaled or ingested. Therefore, as a result of adopting the category for hydrogen bromide, it was classified in category 1 (respiratory organs, teeth). [Evidence Data] (1) As for the hydrogen bromide produced by hydrolysis of this substance, it was reported that decalcification of the teeth, changes in the gums (DFGOT vol. 13 (1999)), cough, shortness of breath, and progressive bronchiolitis obliterans (PATTY (5th, 2001)) were observed. Based on the report, hydrogen bromide is classified in Category 1 (respiratory system, teeth).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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