Item | Information |
---|---|
CAS RN | 72-43-5 |
Chemical Name | 1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane (Methoxychlor) |
Substance ID | H30-B-007-MHLW, MOE |
Classification year (FY) | FY2018 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | It is described that it is combustible (ICSC (1999) (J)), but the classification is not possible due to no data. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. Besides, there is information that it is slightly corrosive to iron and aluminum (HSDB (Accessed Jul. 2018)). |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - |
[Rationale for the Classification] Based on (1)-(4), it was classified as "Not classified" (Category 5 in UN GHS classification or corresponds to "Not classified"). The category was changed from the previous classification according to the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) LD50 values for rats: 3,460-7,000 mg/kg (ATSDR (2002), MAK/BAT (2014)) (2) LD50 value for rats: 5,000 mg/kg (ACGIH (1992)) (3) LD50 value for rats: 6,000 mg/kg (ACGIH (1992)) (4) LD50 values for rats: 5,000-7,000 mg/kg (IARC (1979)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - |
[Rationale for the Classification] Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - |
[Rationale for the Classification] Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - |
[Rationale for the Classification] Although information (1) indicating that this substance is not skin sensitizing was also obtained, adequate evidence was not obtained to judge as "Not classified." Therefore, it was classified as "Classification not possible." [Reference Data, etc.] (1) There is a description that this substance shows little or no skin sensitization (ACGIH (7th, 2001)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
[Rationale for the Classification] From (1) and (2), it was classified as "Classification not possible" in accordance with the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) As for in vivo, there are reports of being negative in a mouse dominant lethal test (IARC 20 (1979)), and negative in chromosomal aberration tests with mouse bone marrow cells and spermatogonial cells (MAK/BAT (2014), ATSDR (2002), ACGIH (1992), IRIS (1988), IARC 20 (1979)). (2) As for in vitro, bacterial reverse mutation tests were negative (MAK/BAT (2014), ACGIH (1992), IRIS (1988), IARC (1979)), gene mutation tests with cultured mammalian cells were positive or negative, a UDS test was negative (MAK/BAT (2014), ATSDR (2002 California), IRIS (1988)), and mouse lymphoma assays were positive or negative (ATSDR (2002), ACGIH (7th, 2001)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - |
[Rationale for the Classification] There are no reports available in humans for carcinogenicity. From (1)-(4), it was classified as "Classification not possible." [Evidence Data] (1) After a commercial product of this substance (purity: 95% or more) was administered by feeding to rats at two doses of the low dose (448 ppm (males), 750 ppm (females)) or the high dose (845 ppm (males), 1,385 ppm (females)) for 78 weeks, the animals were slaughtered and necropsied after a 34-week observation period. A dose-related decreased body weight gain was observed, but there was no increase in the incidence of tumors, and it was concluded that this substance did not show carcinogenicity (NTP TR35 (1978)). (2) After a commercial product of this substance (purity: 95% or more) was administered by feeding with mice at two doses of the low dose (1,746 ppm (males), 997 ppm (females)) or the high dose (3,491 ppm (males),1,994 ppm (females)) for 78 weeks, the animals were slaughtered and necropsied after a 15-week observation period. A dose-related decreased body weight gain was observed, but there was no increase in the incidence of tumors, and it was concluded that this substance did not show carcinogenicity (NTP TR35 (1978)). (3) In addition to the results of the studies of (1) and (2), IARC summarized the results of multiple studies by oral administration with rats, pointed out that hepatocarcinogenicity observed in the early studies was not confirmed in later studies, and concluded that there is no evidence that this substance is carcinogenic in experimental animals (IARC 20 (1979)). (4) As for classification results by domestic and international organizations, it was classified in Group 3 by IARC (IARC Suppl. 7 (1987)), in A4 by ACGIH (ACGIH (7th, 2001)), and as D by EPA (IRIS (2003)). |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 |
P308+P313
P201 P202 P280 P405 P501 |
[Rationale for the Classification] From (1), effects on fertility in the next generation were observed at doses where general toxicity and reproductive effects (decreased sperm counts and reproductive organs weight, decreased fertility index) were observed in maternal animals. On the other hand, this substance possesses estrogenic effects, and it is considered that effects on sexual function and fertility observed in female and male animals are likely to be applicable to humans from the viewpoint of endocrine mediated mechanisms such as estrogenic effects (ATSDR (2002)). Therefore, it was judged as reasonable to classify in category 1B. The category was changed because data were newly obtained from the information source in List 1. [Evidence Data] (1) In a 2-generation reproductive toxicity study with rats, decreased body weight gain and decreased food consumption were observed in both sexes of parental animals by the administration of 500 ppm or above, decreases in the sperm counts and reproductive organ weights in males, and prolonged estrous cycles and decreases in fertility index and in ovary weights in females were observed. Also in F1 pups, effects on fertility were similarly observed by the administration of 500 ppm or above (MAK/BAT (2014)). [Reference Data, etc.] (2) In a developmental toxicity test in which rats were administered by gavage from postnatal day 21 to sexual maturity, by administration of 25 mg/kg/day, earlier vaginal opening of females and increased FSH and TSH levels, and by administration of 50 mg/kg/day, decreased epididymal weight, decreased sperm counts, etc. in males are reported (MAK/BAT (2014), ATSDR (2002)). (3) In a study in which male rats were administered from gestational day 14 to postnatal day 42 (exposed via maternal animals until weaning, directly exposed after weaning), decreased testis weights of males, etc. are reported (MAK/BAT (2014), ATSDR (2002)). |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system) |
Warning |
H371 |
P308+P311
P260 P264 P270 P405 P501 |
[Rationale for the Classification] From (1), it was classified in Category 2 (nervous system). Besides, the human case in (2) was not used for classification since it was a case of only one person. [Evidence Data] (1) In a single oral dose test in which 1,000 mg/kg (within the range of Category 2) was administered to rats, effects on the nervous system such as tremors, dyspnea, convulsions, and paralysis were observed (ATSDR (2002)). [Reference Data, etc.] (2) As for humans, there is a case report that a 62-year-old man who ingested 125 mL of a commercial preparation containing 15 mg of this substance, showed no response to pain and verbal stimuli, resulting in decreased blood pressure, increased pulse rate, pale skin and profuse sweating (ATSDR (2002)). |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (nervous system, liver, endocrine system, genetic organs) |
Warning |
H373 |
P260
P314 P501 |
[Rationale for the Classification] Based on (1)-(3), since it was decided that the adrenal gland is included in the endocrine system organs, it was classified in Category 2 (nervous system, liver, endocrine system, genetic organs). Besides, a new information source was added to information sources in the previous classification, and the target organ was reviewed. [Evidence Data] (1) In a 28-day study with rats dosed by gavage, in males, atrophy of the acinus of the breast at or above 20 mg/kg/day (converted guidance value: corresponds to 6.7 mg/kg/day, within the range of Category 1), atrophy of the epididymis, prostate, seminal vesicle, coagulating gland at or above 100 mg/kg/day (converted guidance value: corresponds to 31 mg/kg/day, within the range of Category 2), in females, abnormal sexual cycle, decreased serum luteinizing hormone, effects on the ovary (decreased weight, atrophy of the ovary due to decrease in the number of follicles and corpora lutea), proliferation of acinus of the breast, and hypertrophy of the endometrial epithelium and vaginal epithelium at or above 100 mg/kg/day were observed. In both males and females, hypertrophy of hepatocytes and adrenal gland cells, and elevation of serum triiodothyronine were observed at or above 100 mg/kg/day (MAK/BAT (2017)). (2) There is a report that in a test in which 1,000 ppm of this substance was administered by feeding to rats for 27 months, decreased weight, hydropic degeneration, necrosis and congestion in the liver were observed (IRIS (2003)). (3) There is a report that in a 2-year study with dogs dosed by feeding, tremors and convulsions were observed at or above 2,000 mg/kg/day within the range of Category 2 (IARC (1979)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 96-hour EC50 (behavior) = 0.0018 mg/L for crustacea (Asellus communis) (ECETOC TR91: 2003). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 because it is not rapidly degradable, and 140-day NOEC (lethal) = 0.023 mg/L for fish (Cyprinodon variegatus) (ECETOC TR91: 2003). Data in the species cannot be used for classification originally because it is ovoviviparous. However, the data were used because the lethal effects of the substance were large, and toxicity of similar or more than that is expected for other fish species. For a trophic level for which chronic toxicity data are not obtained (for algae), acute toxicity data were not obtained, therefore, the classification is not possible. From the above results, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
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