Item | Information |
---|---|
CAS RN | 7779-90-0 |
Chemical Name | Zinc phosphate |
Substance ID | H30-B-018-MHLW, MOE |
Classification year (FY) | FY2018 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2008 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Accessed Aug. 2018)). |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Accessed Aug. 2018)). |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (GESTIS (Accessed Aug. 2018)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metal (Zn). However, because there is an observation result that it is insoluble in water (GESTIS (Accessed Aug. 2018)), it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen, but the classification is not possible due to no data. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - |
[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (EU-RAR (2008)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - |
[Rationale for the Classification] Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) There is a report that zinc oxide, an analogue, is not irritating to the skin (EU-RAR (2008)). |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - |
[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) There is a report that in an eye irritation test (OECD TG405, GLP-compliant) with rabbits, when this substance was applied, mild conjunctival irritation and conjunctival edema (each score of 1 or less) were observed, but they resolved within 72 hours (EU-RAR (2008), REACH registration dossier (Accessed Aug. 2018)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) As for zinc oxide, an analogue, there is a report that in a maximization test (OECD TG406, GLP-compliant) with guinea pigs, skin sensitization was not observed (REACH registration dossier (Accessed Aug. 2018)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) In an assessment from the EU, it is concluded that there is no evidence that zinc is genotoxic in vivo (EU-RAR (2008)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
[Rationale for the Classification] There are no data on this substance itself in either humans or experimental animals. On the other hand, the toxic effects related to the administration of this substance seem to be due to zinc ions after absorption into the body, and the EU conducted the evaluation using data on other zinc compounds (EU-RAR (2008)). So, the reproductive effects of other zinc compounds were also considered in this classification. As for effects on humans, in (1) it is reported that reproductive and developmental effects were not observed. As for experimental animals, in (2)-(4), the possibility of an effect on the genetic organs and an effect on fertility is reported. From the above, based on the results of animal tests for zinc compounds, this substance was classified in Category 2. [Evidence Data] (1) There is a report that no reproductive and developmental effects were observed in pregnant women who ingested orally 0.3 mg Zn2+/kg/day of zinc sulfate or zinc citrate during the last 6 months of gestation (EU-RAR (2008)). However, there is no report of adverse effects on human reproduction due to overdose (EU-RAR (2008)). (2) In a test, in which male rats were dosed by feeding with anhydrous zinc sulfate for 30-32 days before mating, decreased sperm counts were observed at a dose of 200 mg Zn2+/kg/day (EU-RAR (2008)). (3) When female rats were dosed with anhydrous zinc sulfate at a dose of 200 mg Zn2+/kg/day after mating with males, reduced conception was observed (EU-RAR (2008)). (4) There is a report that in a test, in which male and female rats were repeatedly administered zinc monoglycerolate, hypoplasia of seminiferous tubules in males and hypoplasia of the uterus in females were observed at a dose of 300 mg Zn2+/kg/day. Besides, in developmental toxicity tests of zinc sulfate with mice, rats, hamsters, and rabbits, no effects were observed in either maternal animals or fetuses (EU-RAR (2008)). |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
[Rationale for the Classification] Based on (1), although this substance is corresponding to "Not classified" in the oral route, it was classified as "Classification not possible" due to lack of toxicity information in other routes. [Evidence Data] (1) As a result of single oral exposure to rats, no effect was observed within or lower than the dose range of Category 2 (EU-RAR (2008)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (haemal system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
[Rationale for the Classification] As for this substance, there are no available data on either humans or experimental animals for classification. However, on an assessment of the EU, the EU conducted an evaluation using data on other zinc compounds based on the consideration that biological activities after intake of zinc compounds are due to zinc ions, (EU-RAR (2008)). Therefore, also in this hazard class, it was determined to consider repeated exposure effects of other zinc compounds. Based on (1) and (2), though it is described that anemia does not occur in daily life in humans, the possibility of anemia as an effect on the hemal system due to long-term exposure cannot be excluded. Therefore, it was classified in Category 1 (hemal system). [Evidence Data] (1) There is a report that in humans who ingested zinc supplement, at 150 mg Zn2+/day (2.5 mg Zn2+/kg/day, a converted value equivalent to this substance: 14.8 mg/kg/day), headache, nausea, gastric discomfort, disturbance of copper homeostasis (a decrease in serum ceruloplasmin activity, a decrease in erythrocyte SOD activity, a decrease in platelet cytochrome c oxidase) occur (EU-RAR (2008), SIDS SIAP (2005)). (2) As for humans, there is a report of cases of anemia due to copper deficiency following zinc overdose. However, in the case report of long-term intake of zinc for treatment purposes, it is reported that erythrocyte dysfunction due to zinc overdose doesn't occur in the usual dietary life (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). [Reference Data, etc.] (3) It is reported that in a 13-week oral administration test with rats and mice (zinc sulfate heptahydrate, zinc monoglycerolate), no toxic findings were observed within the dose range up to Category 2 (100 mg this substance/kg/day) as a converted value equivalent to this substance, and that a decreased copper level in the blood and effects on the pancreas and spleen were observed at a dose exceeding the range of Category 2 (EU-RAR (2008)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 48-hour LC50 = 0.08 mg/L [converted value 0.04 mgZn/L] for crustacea (Daphnia pulex) (WHO/IPCS EHC: 2001). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 from 72-hour NOEC (cell growth) = 0.06 mg/L [converted value 0.03 mgZn/L] for algae (Pseudokirchneriella subcapitata) (WHO/IPCS EHC: 2001) despite unknown environmental dynamics of the metal compound. If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 from 96-hour LC50 = 0.120 mg/L [converted value 0.061 mgZn/L] for fish (Oncorhynchus clarkii) (WHO/IPCS EHC: 2001) despite unknown environmental dynamics of the metal compound. From the above results, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
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