GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 142-84-7
Chemical Name Di-n-propylamine
Substance ID H30-B-020-MHLW, MOE
Classification year (FY) FY2018
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2008  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
It was classified in Category 2 based on a flash point of 7 deg C (closed cup) and a boiling point of 109.3 deg C (HSDB (Accessed Sept. 2018)). Besides, it is classified in Class 3, Subsidiary Risk 8, PG II (UN2383) in UNRTDG.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 260 deg C (GESTIS (Accessed Sept. 2018)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
[Rationale for the Classification]
Data in (1)-(2) are reported as LD50 values for rats, and both correspond to Category 4. Therefore, it was classified in Category 4.

[Evidence Data]
(1) LD50 value for rats: 495 mg/kg (NICNAS IMAP (Accessed Jul. 2018))
(2) LD50 value for rats: 930 mg/kg (PATTY (6th, 2012))
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
[Rationale for the Classification]
Based on data of LD50 values in (1)-(2) for rats or rabbits, it was classified in Category 3.

[Evidence Data]
(1) LD50 values for rats or rabbits: 500-1,000 mg/kg (SIAP (2013))
(2) LD50 value for rabbits: 925 mg/kg (NICNAS IMAP (Accessed Jul. 2018))
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - [Rationale for the Classification]
Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4


Warning
H332 P304+P340
P261
P271
P312
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 4. Besides, since the test was conducted at a higher concentration than the saturated vapor pressure concentration (0.46 mg/L) of this substance, it was handled as an inhalation study with mist.

[Evidence Data]
(1) LC50 value (4 hours) for rats : 4.4 mg/L (NICNAS IMAP (Accessed Jul. 2018), HSDB (2008))
(2) LC50 value (1 hour) for rats: >8.22 mg (converted 4-hour equivalent value: >2.06 mg) (HSDB (2008))
2 Skin corrosion/irritation Category 1A


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1A. Besides, the category was changed from the previous classification by using new information sources.

[Evidence Data]
(1) In a GLP-compliant study in which rabbits were divided into 4 groups (n=3) and exposed to 0.5 mL of this substance by patch for one minute, necrosis with erythema was observed in one or more animals 1 hour after application in the group in which the skin was wiped with dry gauze, in the group in which the skin was washed with distilled water, and in the group in which the skin was swabbed with PEG 300 after washing with distilled water (NICNAS IMAP (Accessed Jul. 2018), REACH registration dossier (Accessed Sept. 2018), HSDB (2014)).
(2) There is a report that in a Draize test with rabbits (n=3), erythema and edema were observed after a 3-minute application, and this did not resolve after 7 days (REACH registration dossier (Accessed Sept. 2018)).

[Reference Data, etc.]
(3) In a Draize test or a test similar to OECD TG404 with rabbits, aliphatic secondary amines are known to be corrosive to the skin (SIAP (2013))
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
[Rationale for the Classification]
Based on (1)-(3), it was classified in Category 1.

[Evidence Data]
(1) It was classified in Category 1A for skin corrosion/irritation.
(2) There is a report of severe corneal damage in an eye irritation test (OECD TG405) with rabbits (NICNAS IMAP (Accessed Jul. 2018))
(3) This substance is considered to cause strong eye irritation (PATTY (6th, 2012), HSDB (2014)).
4 Respiratory sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - [Rationale for the Classification]
There are animal study data in (1) and (2), but they were judged inadequate to classify as "Not classified." Therefore, it was classified as "Classification not possible."

[Evidence Data]
(1) There is a report that no sensitization was induced, and necrosis was observed when this substance was applied to the ears of mice (NICNAS IMAP (Accessed Jul. 2018)).
(2) There is a report that when a solution of this substance (plural preparations at 0.05-100%) was applied to the ears and abdomens of mice, reactions were shown in both the treated and control groups. Therefore, irritation and sensitization were indistinguishable (REACH registration dossier (Accessed Sept. 2018)).

[Reference Data, etc.]
(3) There is a description that this substance may be a sensitizer (PATTY (6th, 2012)).
5 Germ cell mutagenicity Classification not possible
-
-
- - [Rationale for the Classification]
There are no in vivo data. Therefore, classification was not possible due to lack of data.

[Evidence Data]
(1) As for in vitro, it is reported that it was negative in a bacterial reverse mutation test (HSDB (2008), REACH registration dossier (Accessed Sept. 2018)).
6 Carcinogenicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
[Rationale for the Classification]
Based on the data in (1), it is not clear whether it was based on specific cases or case reports, but this substance is considered to be irritating to the respiratory tract in humans, and also from the data in (2), it is considered to produce respiratory organs irritation at higher concentrations. In addition, this substance is a corrosive liquid. Therefore, it was classified in Category 3 (respiratory tract irritation). Besides, the classification result was changed from the previous classification.

[Evidence Data]
(1) There is a description that inhalation in humans causes severe coughing and chest pain due to respiratory tract irritation and may result in lung edema, headache, nausea, and faintness (HSDB (2008)).
(2) There is a report that as a result of inhalation exposure of rats to a mean concentration of 110 mg/L for up to 15 minutes, all the animals developed labored breathing, gasping, loss of equilibrium and forced movements after 10-12 minutes, and exposure was aborted after 15 minutes because the animals became prostrate (HSDB (2008)). (Note: The results of this study cannot be extrapolated to the guidance value because it is described in the GHS classification guidance for the Japanese Government that only data of exposure time not less than 30 minutes are used for classification. The calculated concentration is 21.3 mg/L (converted 4-hour equivalent value), corresponding to exceeding the range of Category 2).

[Reference Data, etc.]
(3) In a test in which 100-1,600 mg/kg was administered by gavage to mice, weakness, ataxia, and convulsions were observed at 1,600 mg/kg (HSDB (2008)).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - [Rationale for the Classification]
The target organ cannot be identified from the data in (1). In addition, since no other data are available for classification, it was classified as "Classification not possible" due to lack of data.

[Evidence Data]
(1) In a study in which rats were administered by feeding at doses of 75-300 mg/kg/day for 2 weeks, decreased body weight gain and food consumption were observed in males and females of the 300 mg/kg/day group, but it was pointed out that the decrease in food consumption may be due to palatability. At necropsy, findings such as dilation of the renal pelvis were observed in the kidney, but histopathological changes were not observed in the liver and kidney (HSDB (2008), PATTY (6th, 2012), REACH registration dossier (Accessed Sept. 2018)).
10 Aspiration hazard Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
It was classified in Category 3 from 72-hour EC50 (growth rate, pH not adjusted) = 11.8 mg/L for algae (Desmodesmus subspicatus) (OECD SIDS: 2013).
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - Chronic toxicity data were not obtained. Although appropriate data on rapid degradability were not obtained, it was classified as "Not classified" due to no bioaccumulation (LogKow: 1.67 (PHYSPROP Database: 2018)).
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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