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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	109-06-8
Chemical Name	2-Methylpyridine (2-Picoline)
Substance ID	H30-B-021-MHLW, MOE
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2008
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	A flash point is 27 deg C (closed cup) (GESTIS (Accessed Sept. 2018)). Besides, it is classified in Class 3, PG III (UN2313) in UNRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 535 deg C (GESTIS (Accessed Sept. 2018)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] Based on data in (1), an LD50 value for rats, it was classified in Category 4. [Evidence Data] (1) LD50 value for rats: 790 mg/kg (PATTY (6th, 2012)) [Reference Data, etc.] (2) The range of LD50 values for rats and mice: 400-1,600 mg/kg (PATTY (6th, 2012))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	[Rationale for the Classification] Based on data in (1), an LD50 value for rabbits, it was classified in Category 3. [Evidence Data] (1) LD50 value for rabbits: 410 mg/kg (PATTY (6th, 2012))
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	[Rationale for the Classification] Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	[Rationale for the Classification] As for the 4-hour LC50 value for rats, the data from (1) are reported and they correspond to Category 3 to Category 4. The category with the higher hazard was adopted, and it was classified in Category 3. Since the exposure concentration is lower than 90% of the saturated vapor concentration (14,736 ppm), the reference value in units of ppm was applied as a vapor with little mist. The category was changed from the previous classification by use of the new information sources. [Evidence Data] (1) LC50 value for rats (4 hours): between 2,000-4,000 ppm (death of 0/6 animals at 2,000 ppm and 6/6 animals at 4,000 ppm) (REACH registration dossier (Accessed Sept. 2018))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. Besides, information for subcategorization was not obtained. [Evidence Data] (1) There is a report that in a skin irritation test (U.S. 49 CFR 173.240) with rabbits (n=6), after a 4-hour occlusive application of this substance, ulceration or necrosis was observed in all animals (REACH registration dossier (Accessed Sept. 2018)). (2) Although the animal species is unknown, this substance is moderately to severely irritating, and signs of necrosis, ulceration and regeneration are reported (PATTY (6th, 2012)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Severe irritation is reported in animal studies (2) and (3), but based on (1), it was classified in Category 1. [Evidence Data] (1) It was classified in Category 1 for Skin corrosion/irritation. (2) Severe irritation is reported in two eye irritation tests with rabbits (REACH registration dossier (Accessed Sept. 2018)). (3) Although the animal species is unknown, it is reported that this substance is moderately to severely irritating (PATTY (6th, 2012)). (4) Although this substance is judged to be irritating based on an eye irritation test, which reports that keratitis lesions in the corneal epithelial tissue and fibrillary edematous lamellae dissociation were observed (HSDB (2015)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] There is no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, it was negative in bacterial reverse mutation tests (PATTY (6th, 2012), REACH registration dossier (Accessed Sept. 2018)). (2) As for in vitro, it was negative in a mammalian cell gene mutation test (PATTY (6th, 2012), REACH registration dossier (Accessed Sept. 2018)). (3) As for in vitro, it was negative in a mammalian cell chromosomal aberration test (REACH registration dossier (Accessed Sept. 2018)).
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. Although it was classified in Category 2 based on (1) in the previous classification, it was judged that the data was not applicable for classification since it is a test result with only one dose and details including the presence or absence of material toxicity are unknown. [Reference Data, etc.] (1) There is a report that as a result of oral administration to pregnant rats at 157 mg/kg/day throughout the gestation period, disruption of the structure and composition of the liver and structure and growth pattern on the skin were observed in offspring in the administration group (HSDB (2015)).
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Although the human findings in (1) and (2) are thought to be findings on the isomer mixture, it was judged that this is also applicable to this substance, which is a single isomer. Therefore, it was classified in Category 1 (central nervous system). Besides, the category was changed from the previous classification by using new information sources. [Evidence Data] (1) There is a description that in humans, the main actions reported for simple methyl derivatives of pyridine are local irritation and central nervous system depression (PATTY (6th, 2012)). (2) There is a description that in humans, poisoning symptoms by methylpyridine are weight loss, diarrhea, weakness, ataxia, unconsciousness, central nervous system depression, headache, nausea, and vomiting (HSDB (2015), PATTY (6th, 2012)). [Reference Data, etc.] (3) As for experimental animals, there is a report that in an acute toxicity test in which this substance was administered by gavage to male rats at doses of 550-950 mg/kg, which is within the range of Category 2, in the 950 mg/kg group, 4/10 animals died, and signs of encephalomalacia were observed in 2/6 surviving animals (HSDB (2015)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, haemal system)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Although the data in (1) is considered to be the findings on the isomer mixture, it was judged that these are also applicable to this substance, which is a single isomer. And based on the data in (1) and (2), it was classified in Category 1 (central nervous system, hemal system). [Evidence Data] (1) There is a description that in humans, chronic exposure to methylpyridine causes anemia and ocular and facial paralysis in addition to the symptoms of central nervous system depression (HSDB (2015)). (2) There is a report that as a result of inhalation exposure of rats to 5-100 ppm for 6 months, a decrease in the erythrocyte count was observed, which is consistent with the findings in humans. However, it is described that reproducibility was not demonstrated (HSDB (2015)). [Reference Data, etc.] (3) As for experimental animals, in tests in which rats, rabbits and guinea pigs were exposed by inhalation at 25-100 ppm for 6 months, vacuolization of hepatocytes was observed in guinea pigs, but the dose where this was manifested is unclear, and no effects were observed in other animal species (PATTY (6th, 2012), GESTIS (Accessed Sept. 2018)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" from 96-hour LC50 = 897 mg/L for fish (Pimephales promelas) (NLM HSDB: 2018, EPA AQUIRE: 2018, Geiger D. L. et al. (1986)).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Chronic toxicity data were not obtained. Although it is not rapidly degradable (not readily degradable, an average degradation rate by BOD: 1% (J-CHECK, 1998)), it was classified as "Not classified" due to no bioaccumulation (LogKow: 1.11 (PHYSPROP Database: 2018)) and because it was classified as "Not classified" in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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