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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7790-94-5
Chemical Name	Chlorosulfonic acid
Substance ID	H30-B-022-MHLW, MOE
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (ICSC (J) (2001)).
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (halogenated sulfonyl compounds) present in the molecule, but because it is classified in Class 8, PG I (UN1754) in UNRTDG, it was classified as Type G.
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (ICSC (J) (2001)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (J) (2001)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). Besides, it reacts vigorously with water and produces hydrochloric acid and sulfuric acid, not flammable gases.
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen and halogen (Cl), but the classification is not possible due to no data. Besides, it is described in ICSC (J) (2001) that it is a strong oxidant.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Because it reacts vigorously with water and produces hydrochloric acid and sulfuric acid, it is estimated to be corrosive to metals, but the classification is not possible due to no data.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] Based on the data in (1), an LD50 value for rats, it was classified in Category 2. [Evidence Data] (1) LD50 value for rats: 50 mg/kg (GESTIS (Accessed Sept. 2018))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	[Rationale for the Classification] Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	[Rationale for the Classification] The data in (1) corresponds to Category 2-"Not classified," but based on the fact that 8/20 dead animals were observed at 1.765 mg/L, it was classified in Category 2 by adopting the category with the higher hazard. Since the exposure concentration is lower than 90% of the saturated vapor concentration (986 ppm, 4.7 mg/L), (1) and (2) are considered to be inhalation tests by a vapor without a mist. In addition, the data in (2) used for the previous classification was not used for classification since it was assigned as reliability 4 (not assignable) based on that descriptions of the exposure concentration, etc. are insufficient in the REACH registration dossier. [Evidence Data] (1) LC50 value for rats (4 hours): >1.765 mg/L (370 ppm) (8/20 deaths at 1.765 mg/L, 13/20 at 2.768 mg/L, 9/20 at 5.864 mg/L) (SIAP (2006), AEGL (2008)) [Reference Data, etc.] (2) LC50 value for rats (4 hours): 0.0385 mg/L (8 ppm) (HSDB (2003), REACH registration dossier (Accessed Sept. 2018))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. Besides, information for subcategorization was not obtained. [Evidence Data] (1) There is a description that it is strongly irritating and corrosive to the human skin (HSDB (2003)). (2) There is a description that the vapor of this substance is strongly irritating to the mucous membranes of the skin (HSDB (2003), AEGL (2008)). [Reference Data, etc.] (3) It was classified as "Skin Corr. 1A" in EU CLP.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Evidence Data] (1) It was classified in Category 1 for Skin corrosion/irritation. (2) It is described that it is strongly irritating and corrosive to human eyes (HSDB (2003)). (3) There is a description that the vapor of this substance is strongly irritating to the mucous membranes of eyes (HSDB (2003), AEGL (2008)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (respiratory organs). [Evidence Data] (1) There is a description for humans, the vapour generated from this substance is generally strongly irritating and corrosive to the eyes and respiratory tract and that there is a risk of serious damage to the lung at high concentrations or for prolonged exposure (GESTIS (Accessed Sept. 2018)). (2) In a test in which rats were exposed by inhalation to this substance (estimated as a vapour) for 4 hours, concentration-dependent irritation of the respiratory tract and symptoms of central nervous system depression were observed. There is no description of doses, but it is described that LC50 is above 1.765 mg/L (GESTIS (Accessed Sept. 2018)). [Reference Data] (3) As for experimental animals, there are reports that as results of inhalation exposure of rats to 40 mg/m3 for 4 hours and of mice to 25-52 mg/m3 for 2 hours, strong respiratory tract irritation, motor disturbance, and tonic cramps were observed, and histologically, changes of the liver and kidney, brain congestion and focal bleeding in the heart were observed. However, it is pointed out that the concentration analysis of the test substance is insufficient, and the validity of the experiment is not assessable (GESTIS (Accessed Sept. 2018)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, teeth)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] As for the data in (2), because of insufficient description, the dose and the findings cannot be strictly correlated. However, from the description that guinea pigs are the most sensitive, it can be estimated that the above effect was observed even in the 14-day exposure group at 30 mg/m3, and it was considered as an effect within the concentration range of Category 1 (converted guidance value: 0.0047 mg/L). Therefore, based on the findings in humans in (1) and the findings of experimental animals in (2), it was classified in Category 1 (respiratory organs, teeth). Besides, the classification result and the category were changed from the previous classification by using the new information source. [Evidence Data] (1) In humans, the effects of this substance are similar to those of the aerosols of sulfuric acid and hydrochloric acid, and even at low concentrations, it affects the teeth (erosion, discoloration) like those 2 acids. In addition, there is a description that the same is true for irritation to the mucous membranes, mainly the eyes and upper respiratory tract (GESTIS (Accessed Sept. 2018)). (2) As for experimental animals, there are descriptions that in tests where guinea pigs or monkeys were exposed by inhalation at 30 mg/m3 for 14 days or 60 mg/m3 for 7 days (6 hours/day), in guinea pigs, death occurred in high frequency, and bronchial spasms, lung damage, and congestion in the inner organs were observed. Guinea pigs were most sensitive to the effects of exposure. It is described that inflammation occurred at high concentrations in monkeys although there were no dead animals (GESTIS (Accessed Sept. 2018)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 72-hour EC50 (growth rate, pH 5.3) = 0.195 mg/L for algae (Pseudokirchneriella subcapitata), and 48-hour EC50 (pH 5.3) = 0.195 mg/L for crustacea (Daphnia magna) (both OECD SIDS: 2006).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	Chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable and was classified in Category 1 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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