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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	78-87-5
Chemical Name	1,2-Dichloropropane
Substance ID	H30-C-001-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2008 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Because sufficient evidence of carcinogenicity was observed in humans ((1), (2)), it was classified in Category 1A. By using information published after the previous classification, the category was revised. [Evidence Data] (1) Out of 62 workers who had worked in a printing plant for one year or longer, at least 11 developed cholangiocarcinoma inside or outside of the liver, and six of them died. Estimated exposure concentrations of this substance were 100-670 ppm, and estimated exposure duration was 7-17 years. Ten of them had also been exposed to dichloromethane (estimated exposure concentrations: 80-540 ppm, exposure duration: 1-13 years). Moreover, in a report of two workers who had worked in other facilities and developed cholangiocarcinoma, and in a report of six workers who had worked in three different facilities and developed cholangiocarcinoma, many of them had been simultaneously exposed to dichloromethane and chlorine compounds other than this substance, and all of them had been exposed to this substance at concentrations higher than other chemicals. Therefore, it is reported that this substance plays an important role in onset of cholangiocarcinoma (OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH), 2014)) (2) IARC analyzed case reports of cholangiocarcinoma in printing plants in Japan and concluded that there is sufficient evidence for the carcinogenicity of this substance in humans (IARC 110 (2017)). (3) As for classification results by domestic and international organizations, it was classified in Group 1 by IARC (IARC 110 (2017)), Carc. 1B by EU CLP (EU CLP), and Group 1 by Japan Society for Occupational Health (JSOH) (OEL Documentations (Japan Society For Occupational Health, 2017): proposed in 2014). EU adopted (5) Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) in Japan, but it regarded the result (1) to be limited. Moreover, ACGIH classified it in A4 (ACGIH (7th, 2014)), but either (5) or (1) is not included in its evaluation. [Reference Data, etc.] (4) In a test in which rats and mice were dosed by gavage for 103 weeks, a significant increase in hepatocellular adenoma and carcinoma (combined) was observed in male mice of the high dose group (250 mg/kg) and female mice of the low and high dose groups (125, 250 mg/kg) (NTP TR263 (1986)). (5) In a test in which rats or mice were given 104-week inhalation exposure, 6 hours/day, 5 days/week, in rats, an increased incidence of squamous cell papilloma of the nasal cavity was found in both males and females at 500 ppm, and in mice, increased incidences of Harderian gland adenoma (males) and bronchiolar alveolar adenoma and carcinoma (combined) (females) were observed at 200 ppm (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 2005)). (6) Based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, cholangiocarcinoma due to work involving exposure to this substance is included in Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare. Moreover, based on paragraph (3) of Article 28 of the Industrial Safety and Health Act, it is subject to guidelines in order to prevent the impairment of worker's health caused by the chemical substances decided by the Minister of Health, Labour and Welfare (Based on paragraph (3) of Article 28 of the Industrial Safety and Health Act, this substance is subject to guidelines in order to prevent the impairment of worker's health caused by the chemical substances decided by the Minister of Health, Labour and Welfare (Public announcement on guidelines in order to prevent the impairment of worker's health, No. 23, Oct 10, 2012).
7	Reproductive toxicity	-	- -	-	-	-
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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