NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	108-05-4
Chemical Name	Vinyl acetate
Substance ID	H30-C-009-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2009 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Information on carcinogenicity in humans is limited to (4). In tests conducted according to appropriate test guidelines and GLP standards, (1) and (2), clear evidence of carcinogenicity was observed in two animal species including malignant tumors. Therefore, it was classified in Category 1B. As for classification results by domestic and international organizations, it was classified as described in (3). However, the category was revised by putting importance on the fact that clear evidence of carcinogenicity was observed in two animal species including malignant tumors in Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) conducted according to appropriate test guidelines and GLP standards, (1) and (2), and that guidelines were issued by the ministry from concerns on carcinogenicity after discussions in the small committee of hazard evaluation. [Evidence Data] (1) In a carcinogenicity test in rats (2-year drinking water administration), increased incidences of squamous cell carcinoma and papilloma in the oral cavity in a male dosed group and squamous cell carcinoma in the oral cavity and esophagus in female dosed groups were observed (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (1995)). (2) In a carcinogenicity test in mice (2-year drinking water administration), increased incidences of squamous cell carcinoma and papilloma in the oral cavity and stomach and squamous cell carcinoma in the esophagus and larynx were observed in male and female dosed groups (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (1995)). (3) As for classification results by domestic and international organizations, it was classified in Group 2B by IARC (IARC 65 (1995)), in Carc. 2 in EU CLP, in 2B by Japan Society for Occupational Health (JSOH) (proposed in 1998), and in A3 by ACGIH (ACGIH (7th, 2018)). Besides, the results of (1) and (2) were not used in the IARC's evaluation. [Reference Data, etc.] (4) As for carcinogenicity in humans, it is reported that in a cohort study on male workers who had been exposed to 19 different substances including this substance in 1942-1973, undifferentiated large cell lung cancer was associated to a slightly higher cumulative exposure to this substance (IARC 63 (1995), EU-RAR (2008), ACGIH (7th, 2018)), and it is reported from a nested case control study in the USA that exposure to this substance was associated with deaths of employees in two chemical manufacturing facilities from non-Hodgkin's lymphoma, multiple myeloma, lymphocytic or nonlymphocytic leukemia in 1940-1978 (IARC 63 (1995), EU-RAR (2008), ACGIH (7th, 2018), Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)). (5) In a continuous breeding test in which male and female mice and their F1 were dosed in drinking water for 78 weeks, increases in malignant epithelial tumors in the esophagus and forestomach were observed (ACGIH (7th, 2018)). (6) In a continuous breeding test in which male and female rats of three strains and their F1 were dosed in drinking water for 104 weeks, carcinoma in the oral cavity, esophagus, and forestomach increased in F1. There were many deaths in F344 rats, and neoplasm increased while exposure duration was up to 100 weeks (ACGIH (7th, 2018)). (7) In a 2-year inhalation exposure test in rats, squamous cell carcinoma, squamous cell papilloma, and carcinoma in situ in the nasal cavity were observed (IARC 63 (1995), EU-RAR (2008), ACGIH (7th, 2018), Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2010), Environmental Risk Assessment for Chemical Substances Vol. 2 (Ministry of the Environment, 2003), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). (8) Based on paragraph (3) of Article 28 of the Industrial Safety and Health Act, this substance is subject to guidelines in order to prevent the impairment of worker's health caused by the chemical substances decided by the Minister of Health, Labour and Welfare (Public announcement on guidelines in order to prevent the impairment of worker's health, No. 23, Oct 10, 2012).
7	Reproductive toxicity	-	- -	-	-	-
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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