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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	100-44-7
Chemical Name	Benzyl chloride
Substance ID	H30-C-017-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2009 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Information on carcinogenicity in humans is limited to (6). Judging from classification results by IARC and Japan Society for Occupational Health (JSOH), (1) and (2) and test results of (3)-(5), the category was revised form the previous classification, and it was classified in Category 1B. [Evidence Data] (1) IARC classified combined exposures to alpha-chlorinated toluenes (benzyl chloride) and benzoyl chloride in Group 2A by stating that there is sufficient evidence in experimental animals for this substance (IARC 71 (1999)). (2) Japan Society for Occupational Health (JSOH) classified it in Group 2A because it was confirmed to be carcinogenic in animal tests on this substance and positive findings were obtained in mutagenicity tests (OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH), 2001)). As for classification results by domestic and international organizations other than this, it was classified in A3 by ACGIH (ACGIH (7th, 2001)), B2 by EPA (IRIS (1989)), and Carc. 1B in EU CLP (announced in 2008) respectively. (3) In a gavage administration test in rats, thyroid C-cell tumors increased in females, and a few neoplasms in the forestomach were observed in males (IARC 71 (1999), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2005)). (4) In a gavage administration test in mice, increases in papilloma and carcinoma of the forestomach were observed in males and females (IARC 71 (1999), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2005)). (5) Increased incidences of skin carcinomas in a skin application test in mice and sarcomas in the injection sites in a subcutaneous administration test in rats were observed (IARC 71 (1999), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH), 2001), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2005)). [Reference Data, etc.] (6) It is reported in studies on small cohorts of workers exposed to various chlorinated toluenes and benzoyl chloride in the UK and the USA that excess incidences of lung cancers were observed (IARC 71 (1999), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH), 2001)).
7	Reproductive toxicity	-	- -	-	-	-
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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