GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 7496-02-8
Chemical Name 6-Nitrochrysene
Substance ID H30-C-022-MHLW
Classification year (FY) FY2018
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2007  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives -
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- - -
2 Flammable gases (including chemically unstable gases) -
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3 Aerosols -
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4 Oxidizing gases -
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5 Gases under pressure -
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6 Flammable liquids -
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7 Flammable solids -
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8 Self-reactive substances and mixtures -
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9 Pyrophoric liquids -
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10 Pyrophoric solids -
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11 Self-heating substances and mixtures -
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12 Substances and mixtures which, in contact with water, emit flammable gases -
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13 Oxidizing liquids -
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14 Oxidizing solids -
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15 Organic peroxides -
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16 Corrosive to metals -
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HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) -
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- - -
1 Acute toxicity (Dermal) -
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1 Acute toxicity (Inhalation: Gases) -
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1 Acute toxicity (Inhalation: Vapours) -
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1 Acute toxicity (Inhalation: Dusts and mists) -
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2 Skin corrosion/irritation -
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3 Serious eye damage/eye irritation -
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4 Respiratory sensitization -
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4 Skin sensitization -
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5 Germ cell mutagenicity -
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6 Carcinogenicity Category 1B


Danger
H350 P308+P313
P201
P202
P280
P405
P501 		[Rationale for the Classification]
As for carcinogenicity, there is no available report in humans.
Based on the IARC's classification result (1) and test results of (2), (3), it was classified in Category 1B.
The category was revised as the result of reviewing the previous classification due to the revision of the classification in 2014 by IARC.

[Evidence Data]
(1) IARC classified it in Group 2A by stating that there is sufficient evidence in experimental animals for carcinogenicity and by considering mechanism and so on (IARC 105 (2014)). Besides, Japan Society for Occupational Health (JSOH) also classified it in Group 2A (OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)).
Other than these, NTP classified it in R (NTP RoC (14th, 2014)).
(2) In a test in which female rats were orally dosed for eight weeks (once/week), mammary gland carcinoma increased after 23 weeks (IARC 105 (2014), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)).
(3) In an initiation-promotion test in which mice were given applications of ten times on the skin followed by an application of TPA (12-o-tetradecanoylphorbol 13-acetate) as a promoter, squamous cell papilloma increased (IARC 105 (2014), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)).

[Reference Data, etc.]
(4) In a test in which newborn mice were given three intraperitoneal doses, lung tumors increased 26 weeks after the doses (IARC 105 (2014), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)).
(5) In a test in which newborn mice were given three intraperitoneal doses, liver adenoma and adenocarcinoma and malignant lymphoma increased one year after the doses (IARC 105 (2014), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)).
(6) In a test in which mice were given intraperitoneal administration (once), liver tumors. lung tumors, and malignant lymphoma increased one year after the dose (IARC 105 (2014), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)).
(7) There is strong mechanistic evidence to support the carcinogenicity of this substance: in vitro, this substance is metabolized in the human tissues of the liver, lung, and mammary gland to form reactive metabolites that cause DNA damage; the substance produces DNA adducts (IARC 105 (2014)).
7 Reproductive toxicity -
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8 Specific target organ toxicity - Single exposure -
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9 Specific target organ toxicity - Repeated exposure -
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10 Aspiration hazard -
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ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
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- - -
11 Hazardous to the aquatic environment (Long-term) -
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12 Hazardous to the ozone layer -
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NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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