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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	148-24-3
Chemical Name	8-Quinolinol
Substance ID	H30-C-027-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2009
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	-	- -	-	-	-
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] At high doses where general toxicity effects occurred in parent animals, adverse effects on sexual function, genetic organs, and fertility were observed as written in (1). At doses where transient symptoms occurred immediately after administration in maternal animals, an increased incidence of a malformation (omphalocele) was observed in fetuses as written in (2). It is classified in Category 2 by judging the category based on the Guidance, however, at the dose (15 mg/kg/day) where severe developmental effects were seen in (2), the toxicity which occurred in maternal animals were only slight symptoms (excitement, lethargy). Therefore, it was judged to be appropriate to classify it in Category 1B. Besides, the category was revised by the use of a new information source. [Evidence Data] (1) In a two-generation reproductive toxicity test with rats dosed by diet (OECD TG 416, GLP), in F0, F1 parent animals, general toxicity effects (reduced weight gain, decreased food consumption, pigmentation in the liver and so on) were found at or above 3,000 ppm (F0 mating: 291 mg/kg/day), a decrease in the number of estrus cycle and extended length of estrus cycle, decreases in weights of genetic organs (testis, seminal vesicle, prostate, ovary), a decrease in the number of live born pups per litter were observed at the highest dose, 8,000 ppm (before mating of F0: 855 mg/kg/day) as reproductive effects. In offspring, low values of body weight at weaning at 3,000 ppm and at postnatal days 7-21 at 8,000 ppm were found in both F1 and F2, and delayed sexual maturation (delays in preputial separation (males) and vagina opening (females)) was observed in F1 (Background Document to ECHA RAC Opinion (2015)). (2) In a developmental toxicity test (OECD TG 414, GLP) in which pregnant rabbits were dosed by gavage at up to 60 mg/kg/day on gestation days 6-28, symptoms of excitement and lethargy were found in maternal animals after doses of 15 mg/kg/day, and at the same dose or above, an increased incidence of omphalocele, that is a malformation, was observed in fetuses. Except for the above, an increased incidence of preorbital hemorrhage at 15 mg/kg/day and an increased incidence of retinal fold at 60 mg/kg/day were found in fetuses, however, these were regarded as findings within visceral variations (Background Document to ECHA RAC Opinion (2015)). [Reference Data, etc.] (3) In a developmental toxicity test (OECD TG 414, GLP) in which pregnant rats were dosed by gavage at up to 600 mg/kg/day on gestation days 6-19, symptoms (nervous system excitement, lethargy), reduced weight gain, decreased food consumption were found in maternal animals at or above 300 mg/kg/day as clear toxicity. In fetuses, only low values of fetal body weight, visceral variations (enlarged nasal cavity, unilateral hydronephrosis), and skeletal variations (supernumerary rib, delayed ossification) were observed at up to 600 mg/kg/day, and these were findings within slight effects which were not regarded as evidence of developmental effects (Background Document to ECHA RAC Opinion (2015)). (4) It was classified in Repr. 1B in EU CLP.
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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