NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	10124-43-3
Chemical Name	Cobalt(II) sulfate
Substance ID	H30-C-030-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2009
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	-	- -	-	-	-
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] As for data in experimental animals, information on reproductive effects of this substance itself is limited, and toxicity effects related to dosing of this substance are thought to be caused by cobalt ion after absorption in the body. Therefore, information on other water-soluble cobalt compounds was also used for this hazard class. As for effects in humans, it is reported that teratogenicity of cobalt chloride is not observed as written in (5). From (1), (3), (4), water-soluble cobalt compounds cause testicular toxicity and adverse effects on sperms in males and decrease the ability to impregnate females (fertilizing capacity). It is reported that fetotoxicity and teratogenicity occurred at doses where maternal animals did not show marked toxicity in rats and mice (2). From the above, for water-soluble cobalt compounds including this substance, in an oral route, adverse effects on the male genetic organs and decreased fertilizing capacity are reported, and it is reported that teratogenicity was shown at doses without maternal toxicity. Therefore, it was classified in Category 1B for this hazard class. [Evidence Data] (1) In a test in which mice were exposed to cobalt sulfate heptahydrate (CAS: 10026-24-1) by inhalation for 13 weeks, decreased sperm motility at or above 3 mg/m3 and decreased weight of the testis and epididymis, an increased ratio of abnormal sperms at 30 mg/m3 were observed (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), NICNAS IMAP (Accessed Oct. 2018)). (2) As the result of dosing this substance to pregnant rats by gavage through a gestation period, at the doses (25, 50 mg/kg/day) lower than 100 mg/kg/day where maternal animals showed slight effects (increases in relative weight of the liver, adrenal gland, and spleen), in addition to low values of fetal body weight, delayed development and increased malformations (malformations mainly in the cranium, spine, pelvis, renal tubule, ovary, and testis) in the skeletal system and viscera were observed. When pregnant mice were dosed with this substance at 50 mg/kg/day by gavage during the organogenesis period (gestation days 6-15), delayed development of the skeletal system and an increased incidence of malformations (mainly in the eyelid, kidney, cranium, and spine) were also observed in fetuses (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). (3) As the result of dosing male mice with cobalt (II) chloride (CAS: 7646-79-9) by drinking water for 12 weeks followed by mating with untreated females, decreases in the numbers of embryo resorptions and live fetuses at or above 200 ppm (25 mg/kg/day), decreases in the numbers of pregnant females and implantation sites at or above 400 ppm (47 mg/kg/day) were observed. Decreases in weight of the testis, epididymis and so on, a decreased number of sperms in the testis and epididymis, and decreased spermatogenesis were observed in males, and a decreased number of pregnant females is thought to be caused by decreased male fertility (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), NICNAS IMAP (Accessed Oct. 2018), Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009)). (4) As the result of dosing male mice with cobalt (II) chloride by drinking water at 72 mgCo/kg/day for 10 weeks followed by mating with untreated females, a decreased number of pregnant animals, a decreased number of live fetuses per litter, and an increased number of preimplantation losses per litter were observed in a dosed group. The results mentioned above are thought to be effects of decreased male fertility from decreased sperm concentrations. In a recovery group in which dosing males by drinking water was followed by mating and 6-week cessation of dosing, motility and movement speed of sperms became normal while concentrations did not (Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009)). [Reference Data, etc.] (5) It is reported that teratogenicity is not observed in humans and that clinical changes were not observed in newborns from women who took cobalt chloride as an anti-anemia drug at delivery (Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009)). (6) It is classified in Repr. 1B in EU CLP.
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information