Item | Information |
---|---|
CAS RN | 36355-01-8 |
Chemical Name | Hexabromobiphenyl (Polybrominated biphenyl) |
Substance ID | H30-C-033-MHLW |
Classification year (FY) | FY2018 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases (including chemically unstable gases) | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Information on carcinogenicity in humans is limited to (6). Based on the IARC's classification result (1) and test results of (2)-(5), it was classified in Category 1B. The category was revised as the result of reviewing the previous classification due to the revision of the classification in 2016 by IARC. [Evidence Data] (1) It is described in IARC that there is inadequate evidence in experimental animals for Firemaster BP-6 which is one of polybrominated biphenyls (Br 5-7). However, IARC classified the whole PBBs including this substance in Group 2A by stating that there is sufficient evidence for the carcinogenicity of Firemaster FF-1 (CAS: 67774-32-7) in animal tests on the substance, a commercial mixture of FireMaster BP-6 and 2% calcium polysilicate added for anti-caking, and by considering mechanism and so on and similarities to PCB (IARC 107 (2016)). As for classification results by other domestic and international organizations, Japan Society for Occupational Health (JSOH) classified it in Group 2B (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH) 2018)). (2) In a test in which mice were dosed with Firemaster FF-1 by gavage for six months, an increase in hepatocellular carcinoma was observed in males and females after 30 months (NTP TR244 (1983), IARC 107 (2016)). (3) In a test in which mice were dosed with Firemaster FF-1 by diet for two years, an increase in hepatocellular adenoma and carcinoma was observed in males and females. Moreover, after exposure only in the perinatal period in the same protocol, an increase in hepatocellular adenoma and carcinoma was also observed in males and females. After exposure during the perinatal and adult period, increases in hepatocellular adenoma and carcinoma in males and females and thyroid follicular cell adenoma in males were observed (NTP TR398 (1993), IARC 107 (2016)). (4) In a test in which rats were dosed with Firemaster FF-1 by gavage for six months, increases in neoplastic nodules, hepatocellular carcinoma, and cholangiocarcinoma were observed in males and females after 30 months, and mononuclear cell leukemia was also observed in males (NTP TR244 (1983), IARC 107 (2016)). (5) In a test in which rats were dosed with Firemaster FF-1 by diet for two years, an increase in hepatocellular adenoma and carcinoma was observed in males and females. Moreover, after exposure during the perinatal and adult period in the same protocol, increases in mononuclear cell leukemia in males and females and hepatocellular adenoma and carcinoma in females were observed (NTP TR398 (1993), IARC 107 (2016)). [Reference Data, etc.] (6) In a nested case-control study on a cohort of people who were exposed via food contaminated with polybrominated biphenyls (PBB) after the accident in the chemical plant in Michigan, USA, a trend toward increases in lymphoma and cancers of the digestive system are suggested (IARC 107 (2016)). |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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