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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	27858-07-7
Chemical Name	Octabromobiphenyl (Polybrominated biphenyl)
Substance ID	H30-C-034-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Information on carcinogenicity in humans is limited to (6). Based on the IARC's classification result (1) and test results of (2)-(5), it was classified in Category 1B. The category was revised as the result of reviewing the previous classification due to the revision of the classification in 2016 by IARC. [Evidence Data] (1) It is described in IARC that there is inadequate evidence in experimental animals for Firemaster BP-6 which is one of polybrominated biphenyls (Br 5-7). However, IARC classified the whole PBBs including this substance in Group 2A by stating that there is sufficient evidence for the carcinogenicity of Firemaster FF-1 (CAS: 67774-32-7) in animal tests on the substance, a commercial mixture of FireMaster BP-6 and 2% calcium polysilicate added for anti-caking, and by considering mechanism and so on and similarities to PCB (IARC 107 (2016)). As for classification results by other domestic and international organizations, Japan Society for Occupational Health (JSOH) classified it in Group 2B (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH) 2018)). (2) In a test in which mice were dosed with Firemaster FF-1 by gavage for six months, an increase in hepatocellular carcinoma was observed in males and females after 30 months (NTP TR244 (1983), IARC 107 (2016)). (3) In a test in which mice were dosed with Firemaster FF-1 by diet for two years, an increase in hepatocellular adenoma and carcinoma was observed in males and females. Moreover, after exposure only in the perinatal period in the same protocol, an increase in hepatocellular adenoma and carcinoma was also observed in males and females. After exposure during the perinatal and adult period, increases in hepatocellular adenoma and carcinoma in males and females and thyroid follicular cell adenoma in males were observed (NTP TR398 (1993), IARC 107 (2016)). (4) In a test in which rats were dosed with Firemaster FF-1 by gavage for six months, increases in neoplastic nodules, hepatocellular carcinoma, and cholangiocarcinoma were observed in males and females after 30 months, and mononuclear cell leukemia was also observed in males (NTP TR244 (1983), IARC 107 (2016)). (5) In a test in which rats were dosed with Firemaster FF-1 by diet for two years, an increase in hepatocellular adenoma and carcinoma was observed in males and females. Moreover, after exposure during the perinatal and adult period in the same protocol, increases in mononuclear cell leukemia in males and females and hepatocellular adenoma and carcinoma in females were observed (NTP TR398 (1993), IARC 107 (2016)). [Reference Data, etc.] (6) In a nested case-control study on a cohort of people who were exposed via food contaminated with polybrominated biphenyls (PBB) after the accident in the chemical plant in Michigan, USA, a trend toward increases in lymphoma and cancers of the digestive system are suggested (IARC 107 (2016)).
7	Reproductive toxicity	-	- -	-	-	-
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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