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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	111988-49-9
Chemical Name	Thiacloprid
Substance ID	H30-C-036-MHLW, C-083-MOE
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	-	- -	-	-	-
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] From (1), (2), in a two-generation test in rats, at the doses where general toxicity (effects on the live/thyroid) occurred in parent animals, a decrease in survival rate at birth in F1, F2 offspring and dead or urgently slaughtered animals due to dystocia in maternal animals were observed. Moreover, in developmental toxicity tests, at high doses where maternal toxicity was seen, an increased incidence of skeletal malformations in fetuses (3) and growth retardation, delayed sexual maturation, and tooth disorder in liveborn pups (4) were observed. From the above, because this substance caused death or moribund state due to dystocia in maternal animals at the doses without serious general toxicity in maternal animals in two-generation test and one-generation tests in rats, and teratogenicity was observed at the maternal toxicity dose, it was classified in Category 1B for this hazard class. In this re-classification, the category was revised because data were newly obtained from information sources in List 1. [Evidence Data] (1) In a two-generation reproductive toxicity test with rats orally dosed (in the diet) (50-600 ppm), in maternal animals of the parent generation, there were three dead animals and one urgently slaughtered animal in a 300 ppm group and three urgently slaughtered animals in a 600 ppm group, all of which were due to dystocia, and it is thought to be due to marked maternal toxicity. In surviving parent animals of the parent and F1 generations, hepatocellular hypertrophy (males and females) and hypertrophy of thyroid follicular epithelium (females) at or above 300 ppm and hypertrophy of thyroid follicular epithelium (males) at 600 ppm were observed. In F1, F2 offspring, a decrease in survival rate at birth was observed at 600 ppm (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), JMPR (2006)). (2) A one-generation test with rats dosed by feeding (25-1,000 ppm) was conducted to confirm reproducibility of dystocia found in the maternal animals in the two-generation test (1). As a result, animals of difficult deliveries were not observed at 300 ppm of the mid dose (animals with dystocia were found in the two-generation test), in a 1,000 ppm group, six females died or were urgently slaughtered, and four of them died at the start of deliveries or within 24 hours after the start of deliveries (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), JMPR (2006)). (3) In developmental toxicity tests with pregnant rats or rabbits dosed by gavage, in rats, at 50 mg/kg/day of the high dose where maternal animals showed transiently reduced weight gain and decreased food consumption, an increased incidence of limb bones dysplasia (humerus, radius, and scapula) was observed in fetuses in addition to increased number of late resorption of embryos, delayed ossification, and skeletal variations (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), JMPR (2006)). On the other hand, in a test in rabbits, in a high-dose group of 45 mg/kg/day, abortions (2/24 animals), total resorptions of embryos (3/24 animals) in maternal animals, increased post-implantation loss and delayed ossification in fetuses were observed, but skeletal malformations were not found (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), JMPR (2006)). (4) In a developmental neurotoxicity test in which pregnant rats were orally dosed (by feeding) from gestational day 0 to the weaning of live born (50-500 ppm: 4.4-40.8 mg/kg/day), at or above 300 ppm where reduced weight gain was found in maternal animals, offspring showed reduced weight gain (males and females), delayed preputial separation (males), delayed vaginal patency (females), and at 600 ppm, misalignment of the incisors (males) was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), JMPR (2006)). [Reference Data, etc.] (5) This substance was classified in Repr. 1B in EU CLP.
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	-
11	Hazardous to the aquatic environment (Long-term)	Category 2	-	H411	P273 P391 P501	-
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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