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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	334-88-3
Chemical Name	Diazomethane
Substance ID	H30-C-037-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] This substance is a strong irritant which causes damage to the respiratory organs even at lower concentrations (DFGOT Vol. 3 (1999)). Therefore, tests for carcinogenicity assessment are limited to short-time exposure tests, and classification results in (4) are reported from limited animal test results (1)-(3). From (4), the classification result by ACGIH, which classified later than IARC did, was prioritized, and the substance was classified in Category 1B. The category was revised by the use of new information sources. [Evidence Data] (1) As the result of inhalation exposure in male rats (total 13 animals) of two strains to the vapour from an ether solution of this substance (0.1-3.3 mg/L) for 2-3 minutes, twice weekly for six or 4.5 months, pulmonary adenoma was found in three out of seven animals which survived longer than 10 months, and one of these three showed squamous cell carcinoma of the lung which was invasive/metastatic to the diaphragm and skeletal muscle (IARC 7 (1974), DFGOT Vol. 3 (1999)). (2) As the result of inhalation exposure in male mice of the A strain (12 animals) to the vapour from an ether solution of this substance (0.1-3.3 mg/L) for about three minutes (reduced to two minutes after 10 days when deaths of animals occurred), twice weekly for six months, pulmonary adenoma was observed in 7/10 of mice which survived longer than six months (the control group: 2/8 animals). Moreover, as the result of inhalation exposure in male mice of the Swiss strain (five animals) to the vapour of this substance similarly generated for 1.5 minutes/time, 12 times in the first six weeks, lung tumors were observed in all the five animals which survived for six months (the control group: 3/6 animals) (IARC 7 (1974), DFGOT Vol. 3 (1999)). (3) After a few drops of an ether solution of this substance (0.1-3.3 mg/mL) were dermally applied on the dorsal skin of male mice of the A strain (12 animals) five times/week for five months, lung adenoma was observed in all the eight survived animals (IARC 7 (1974), DFGOT Vol. 3 (1999)). (4) IARC described there is limited evidence in experimental animals above and classified it in Group 3 (IARC Suppl. 7 (1987)). It is written in ACGIH that lung adenoma in mice and pulmonary adenoma and squamous cell carcinoma in rats were observed under condition similar to worker exposure, warrant to A2 designation for carcinogenicity classification (ACGIH (7th, 2001): classification in 1996). Other than these, it was classified in 1B in EU CLP. [Reference Data, etc.] (5) The Ministry of Health, Labour and Welfare judged that A2 classification by ACGIH is appropriate, and this substance is probably carcinogenic to humans (Hazard Assessment Table (Ministry of Health, Labour and Welfare, 2010)).
7	Reproductive toxicity	-	- -	-	-	-
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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