GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 693-13-0
Chemical Name 1,3-Diisopropylcarbodiimide
Substance ID H30-C-039-MHLW
Classification year (FY) FY2018
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2010  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives -
-
-
- - -
2 Flammable gases (including chemically unstable gases) -
-
-
- - -
3 Aerosols -
-
-
- - -
4 Oxidizing gases -
-
-
- - -
5 Gases under pressure -
-
-
- - -
6 Flammable liquids -
-
-
- - -
7 Flammable solids -
-
-
- - -
8 Self-reactive substances and mixtures -
-
-
- - -
9 Pyrophoric liquids -
-
-
- - -
10 Pyrophoric solids -
-
-
- - -
11 Self-heating substances and mixtures -
-
-
- - -
12 Substances and mixtures which, in contact with water, emit flammable gases -
-
-
- - -
13 Oxidizing liquids -
-
-
- - -
14 Oxidizing solids -
-
-
- - -
15 Organic peroxides -
-
-
- - -
16 Corrosive to metals -
-
-
- - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) -
-
-
- - -
1 Acute toxicity (Dermal) -
-
-
- - -
1 Acute toxicity (Inhalation: Gases) -
-
-
- - -
1 Acute toxicity (Inhalation: Vapours) -
-
-
- - -
1 Acute toxicity (Inhalation: Dusts and mists) -
-
-
- - -
2 Skin corrosion/irritation -
-
-
- - -
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
[Rationale for the Classification]
Delayed corneal damage though to be effects of the vapour of this substance was seen from (1), and irreversible effects are estimated if tested on a liquid. Therefore, it was classified in Category 1.

[Evidence Data]
(1) It is reported that as for a liquid of this substance spilled to a table and a floor from a 1 L container due to its break, a worker who wiped it off wearing a respirator, laboratory coat, and impervious gloves for 45 minutes to one hour showed hazy vision after about 12-18 hours, and mild pain in the eyes started after four hours and maximized 34 hours after the exposure, and corneal damage was limited to the outer layer, resulting in temporary blindness and initial visual acuity of 20/200 (eyesight 0.1) that subsided over a 2-week period, and the reporter attributed these effects to the vapour of this substance (NTP TR 523 (2007), C&EN, Nov., No. 5, 2 (1990)).

[Reference Data, etc.]
(2) A worker cleaned the U-shaped gutter of a floor without wearing appropriate protective gears such as protective goggles after an experiment of producing this substance developed cornea ulceration and alkaline burns on the cornea, and it is reported that this is caused by exposure to the vapour probably of this substance floated around sludge (Workplace Safety Site (Ministry of Health, Labour and Welfare, Accessed 2019)).
(3) Based on (1), it is reported that effects of exposure to the vapour of this substance resemble mild to moderate effects of mustard gas (NTP TR 523 (2007), C&EN, Jan. 14, 2 (1991)). Moreover, it is pointed out that it is reasonable to assume that all alkylcarbodiimides cause vesication and carcinogenicity by functioning as dealkylating agents based on mechanism of action for mustard gas. It is described that users of this substance are needed to use glove box, fume hood, and full-face mask (C&EN, Jan. 14, 2 (1991)).
(4) It is pointed out that dicyclohexylcarbodiimide (CAS: 538-75-0) which has a similar structure as this substance does causes effects on the corneal epithelium and following notable and delayed keratopathy that subsides (Grant & Schuman (1993)).
4 Respiratory sensitization -
-
-
- - -
4 Skin sensitization -
-
-
- - -
5 Germ cell mutagenicity -
-
-
- - -
6 Carcinogenicity -
-
-
- - -
7 Reproductive toxicity -
-
-
- - -
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, visual organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
[Rationale for the Classification]
By dermal absorption or inhalation of the vapour of this substance, delayed effects on the visual organs are seen from (1). Effects on the nervous system are known for this substance and are thought to cause temporary blindness and so on. Moreover, because corneal damage was limited to the outer layer, it is assumed to affect the cornea directly, therefore, it was classified in Category 1 (central nervous system, visual organs).

[Evidence Data]
(1) It is reported that as for a liquid of this substance spilled to a table and a floor from a 1 L container due to its break, a worker who wiped it off wearing a respirator, laboratory coat, and impervious gloves for 45 minutes to one hour showed hazy vision after about 12-18 hours, and mild pain in the eyes started after four hours and maximized 34 hours after the exposure, and corneal damage was limited to the outer layer, resulting in temporary blindness and initial visual acuity of 20/200 (eyesight 0.1) that subsided over a 2-week period, and the reporter attributed these effects to the vapour of this substance (NTP TR 523 (2007), C&EN, Nov., No. 5, 2 (1990)).

[Reference Data, etc.]
(2) Based on (1), it is reported that effects of exposure to the vapour of this substance resemble mild to moderate effects of mustard gas (NTP TR 523 (2007), C&EN, Jan. 14, 2 (1991)). Moreover, it is pointed out that it is reasonable to assume that all alkylcarbodiimides cause vesication and carcinogenicity by functioning as dealkylating agents based on mechanism of action for mustard gas. It is described that users of this substance are needed to use glove box, fume hood, and full-face mask (C&EN, Jan. 14, 2 (1991)).
(3) It is pointed out that dicyclohexylcarbodiimide (CAS: 538-75-0) which has a similar structure as this substance does causes effects on the corneal epithelium and following notable and delayed keratopathy that subsides (Grant & Schuman (1993)).
9 Specific target organ toxicity - Repeated exposure -
-
-
- - -
10 Aspiration hazard -
-
-
- - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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