Item | Information |
---|---|
CAS RN | 693-13-0 |
Chemical Name | 1,3-Diisopropylcarbodiimide |
Substance ID | H30-C-039-MHLW |
Classification year (FY) | FY2018 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2010 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases (including chemically unstable gases) | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] Delayed corneal damage though to be effects of the vapour of this substance was seen from (1), and irreversible effects are estimated if tested on a liquid. Therefore, it was classified in Category 1. [Evidence Data] (1) It is reported that as for a liquid of this substance spilled to a table and a floor from a 1 L container due to its break, a worker who wiped it off wearing a respirator, laboratory coat, and impervious gloves for 45 minutes to one hour showed hazy vision after about 12-18 hours, and mild pain in the eyes started after four hours and maximized 34 hours after the exposure, and corneal damage was limited to the outer layer, resulting in temporary blindness and initial visual acuity of 20/200 (eyesight 0.1) that subsided over a 2-week period, and the reporter attributed these effects to the vapour of this substance (NTP TR 523 (2007), C&EN, Nov., No. 5, 2 (1990)). [Reference Data, etc.] (2) A worker cleaned the U-shaped gutter of a floor without wearing appropriate protective gears such as protective goggles after an experiment of producing this substance developed cornea ulceration and alkaline burns on the cornea, and it is reported that this is caused by exposure to the vapour probably of this substance floated around sludge (Workplace Safety Site (Ministry of Health, Labour and Welfare, Accessed 2019)). (3) Based on (1), it is reported that effects of exposure to the vapour of this substance resemble mild to moderate effects of mustard gas (NTP TR 523 (2007), C&EN, Jan. 14, 2 (1991)). Moreover, it is pointed out that it is reasonable to assume that all alkylcarbodiimides cause vesication and carcinogenicity by functioning as dealkylating agents based on mechanism of action for mustard gas. It is described that users of this substance are needed to use glove box, fume hood, and full-face mask (C&EN, Jan. 14, 2 (1991)). (4) It is pointed out that dicyclohexylcarbodiimide (CAS: 538-75-0) which has a similar structure as this substance does causes effects on the corneal epithelium and following notable and delayed keratopathy that subsides (Grant & Schuman (1993)). |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, visual organs) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] By dermal absorption or inhalation of the vapour of this substance, delayed effects on the visual organs are seen from (1). Effects on the nervous system are known for this substance and are thought to cause temporary blindness and so on. Moreover, because corneal damage was limited to the outer layer, it is assumed to affect the cornea directly, therefore, it was classified in Category 1 (central nervous system, visual organs). [Evidence Data] (1) It is reported that as for a liquid of this substance spilled to a table and a floor from a 1 L container due to its break, a worker who wiped it off wearing a respirator, laboratory coat, and impervious gloves for 45 minutes to one hour showed hazy vision after about 12-18 hours, and mild pain in the eyes started after four hours and maximized 34 hours after the exposure, and corneal damage was limited to the outer layer, resulting in temporary blindness and initial visual acuity of 20/200 (eyesight 0.1) that subsided over a 2-week period, and the reporter attributed these effects to the vapour of this substance (NTP TR 523 (2007), C&EN, Nov., No. 5, 2 (1990)). [Reference Data, etc.] (2) Based on (1), it is reported that effects of exposure to the vapour of this substance resemble mild to moderate effects of mustard gas (NTP TR 523 (2007), C&EN, Jan. 14, 2 (1991)). Moreover, it is pointed out that it is reasonable to assume that all alkylcarbodiimides cause vesication and carcinogenicity by functioning as dealkylating agents based on mechanism of action for mustard gas. It is described that users of this substance are needed to use glove box, fume hood, and full-face mask (C&EN, Jan. 14, 2 (1991)). (3) It is pointed out that dicyclohexylcarbodiimide (CAS: 538-75-0) which has a similar structure as this substance does causes effects on the corneal epithelium and following notable and delayed keratopathy that subsides (Grant & Schuman (1993)). |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|