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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	142-90-5
Chemical Name	Dodecyl methacrylate
Substance ID	H30-C-040-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2017 FY2008
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Because there are no irritation data on this substance itself, it was classified as "Classification not possible." Besides, it was classified in Skin Irrit. 2 in EU CLP. However, the revision of the current classification is being progressed, and ECHA Risk Assessment Committee (RAC) is proposing the cancel of the current classification. RAC judged that based on physicochemical properties, structural similarity, and metabolic pathway of this substance and related substances (long chain length/short chain length), it is appropriate to estimate skin irritation of this substance from skin irritation data on these related substances by applying the read across and that irritation of this substance does not correspond to Skin Irrit. 2 of the current classification. Because data (1) used in the previous classification were those on the other substance, they were not used for classification this time. [Reference Data, etc.] (1) It is reported that in a skin irritation test with rabbits (OECD TG404, GLP-compliant), after 4-hour semi-occlusive application with undiluted substance related to this substance (isotridecyl methacrylate), mean erythema scores after 24, 48, and 72 hours were 0, 0.33, and 0.66, mean edema scores were 1, 1.33, and 1.66, and subsided within 72 hours (ECHA RAC (2017), REACH registration dossier (Accessed Dec. 2018)). (2) Other than the above, there were three skin irritation tests with rabbits on substances related to this substance, and it is reported that mild irritation with average scores not more than 2 was shown (ECHA RAC (2017)).
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Because there are no irritation data on this substance itself, it was classified as "Classification not possible." Besides, it was classified in Eye Irrit. 2 in EU CLP. However, the revision of the current classification is being progressed, and ECHA Risk Assessment Committee (RAC) is proposing the cancel of the current classification. RAC judged that based on physicochemical properties, structural similarity, and metabolic pathway of this substance and related substances (long chain length/short chain length), it is appropriate to estimate skin irritation of this substance from skin irritation data on these related substances by applying the read across and that irritation of this substance does not correspond to Eye Irrit. 2 of the current classification. Because data (1) (2) used in the previous classification were those on the other substance or a mixture, they were not used for classification this time. [Reference Data, etc.] (1) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), after applying undiluted substance related to this substance (Isotridecyl methacrylate), slight irritation was found one hour after application but resolved within 24 hours, and average scores for corneal opacity, iris, conjunctival redness, and chemosis were all 0 after 24, 48, and 72 hours (ECHA RAC (2017), REACH registration dossier (Accessed Dec. 2018)). (2) It is reported that in an eye irritation test with rabbits (FAD Draize test, n = 6), after applying a mixture of this substance and related substances (undiluted, 65% dodecyl methacrylate, 25% tetradecyl methacrylate, 10% higher alkyl methacrylates up to octadecyl methacrylate), average scores for corneal opacity, iris, conjunctival redness, and chemosis were all 0 after 24, 48, and 72 hours (ECHA RAC (2017), REACH registration dossier (Accessed Dec. 2018)). (3) Other than the above, there are two eye irritation tests with rabbits on a substance related to this substance, and it is reported that mean eye irritation scores were 0 (ECHA RAC (2017)).
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	-	- -	-	-	-
7	Reproductive toxicity	-	- -	-	-	-
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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