Item | Information |
---|---|
CAS RN | 16941-12-1 |
Chemical Name | Hexachloroplatinic acid(IV) |
Substance ID | H30-C-041-MHLW |
Classification year (FY) | FY2018 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2009 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases (including chemically unstable gases) | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] Because the salts of this substance are corrosive to the eye from (1)-(3), and this substance and its salts are categorized into substances with a similar hazard as shown in (4), this substance was classified in Category 1 by using information on the salts. [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), after application of ammonium hexachloroplatinate, two out of three animals showed severe and irreversible effects such as opacity and necrosis of the cornea, moderate circumcorneal hyperemia of the iris, diffuse redness of the conjunctiva, swelling of the eyelids, discoloration of the eyes (REACH registration dossier (Accessed Dec. 2018)). (2) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), as the result of application of potassium hexachloroplatinate, after 24 hours, corneal opacity score was 4, conjunctival redness score 3 (diffuse redness), and chemosis score was 4 (half-closed lids due to swelling), the eye was filled with white mucus and discolored to grey, the animals were sacrificed due to the severity of the symptoms at 24 hours (REACH registration dossier (Accessed Dec. 2018)). (3) It is reported that in eye irritation tests on chlorinated platinates, ammonium tetrachloroplatinate was corrosive, and potassium tetrachloroplatinate and sodium hexachloroplatinate were irritating (EHC 125 (1991)). (4) In the notice No. 181 issued by Director of Labour Standards Bureau, the Ministry of Labour (1996), CAS RN was clearly mentioned for this substance together with other salts (potassium tetrachloroplatinate, ammonium tetrachloroplatinate, sodium hexachloroplatinate, potassium hexachloroplatinate, and ammonium hexachloroplatinate), and it is also written that they cause anterior eye disorders, eye irritation, lacrimation, conjunctival hyperemia as symptoms and disorders. [Rationale for the Classification] Because the salts of this substance are corrosive to the eye from (1)-(3), and this substance and its salts are categorized into substances with a similar hazard as shown in (4), this substance was classified in Category 1 by using information on the salts. [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), after application of ammonium hexachloroplatinate, two out of three animals showed severe and irreversible effects such as opacity and necrosis of the cornea, moderate circumcorneal hyperemia of the iris, diffuse redness of the conjunctiva, swelling of the eyelids, discoloration of the eyes (REACH registration dossier (Accessed Dec. 2018)). (2) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), as the result of application of potassium hexachloroplatinate, after 24 hours, corneal opacity score was 4, conjunctival redness score 3 (diffuse redness), and chemosis score was 4 (half-closed lids due to swelling), the eye was filled with white mucus and discolored to grey, the animals were sacrificed due to the severity of the symptoms at 24 hours (REACH registration dossier (Accessed Dec. 2018)). (3) It is reported that in eye irritation tests on chlorinated platinates, ammonium tetrachloroplatinate was corrosive, and potassium tetrachloroplatinate and sodium hexachloroplatinate were irritating (EHC 125 (1991)). (4) In the notice No. 181 issued by Director of Labour Standards Bureau, the Ministry of Labour (1996), CAS RN was clearly mentioned for this substance together with other salts (potassium tetrachloroplatinate, ammonium tetrachloroplatinate, sodium hexachloroplatinate, potassium hexachloroplatinate, and ammonium hexachloroplatinate), and it is also written that they cause anterior eye disorders, eye irritation, lacrimation, conjunctival hyperemia as symptoms and disorders. [Reference Data, etc.] (5) In the announcement No. 33 of the Ministry of Labour (1996) (revised by the announcement No. 316 of the Ministry of Health, Labour and Welfare, 2013), this substance is designated as "chlorinated platinic acid and its compounds" in Simple chemical substances or compounds designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (skin disorders, anterior eye disorders, or respiratory tract disorders) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare. (6) In the notice No. 0811001 issued by Director of Labour Standards Bureau, the Ministry of Labour (2003), this substance is designated as "chlorinated platinic acid and its compounds" among hazardous substances for which installation of protective equipment to prevent eye disorders such as protective glasses is mandated in Article 593 in the Industrial Safety and Health Regulations. (7) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant), after application of potassium tetrachloroplatinate, either of corneal opacity, iridial and conjunctival redness, or chemosis did not resolve in two out of three animals 72 hours after application (REACH registration dossier (Accessed Dec. 2018)). |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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