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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7681-57-4
Chemical Name	Disodium pyrosulfite
Substance ID	H30-C-042-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2013 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	[Rationale for the Classification] Because there is knowledge that this substance is sensitizing in humans from (1)-(4), it was classified in Category 1. Besides, it is described in the minutes of the subcommittee on diseases due to chemical substances, Expert Committee of Article 35, the Ordinance for Enforcement of the Labor Standards Act (2013) that there are case reports on allergic contact dermatitis and asthma from occupational exposure to this substance, and onset of these is possible in normal workplaces. The category was revised from the previous one because new information was obtained. [Evidence Data] (1) It is reported: occupational asthma of a 37-year-old female radiographer who handled this substance as the fixing agent was suspected to be associated with the substance; therefore, a challenge test was conducted on the patient and nine controls, and the patient and one control showed positive response; epidemiological evidence was confirmed for the association between this substance and occupational asthma (Eur Respir J. 25 (2), 386-388 (2005)). (2) It is reported that a laundry worker who used this substance as an additive chemical developed occupational asthma (ACGIH (7th, 2001)). (3) It is reported that severe asthma was provoked in a 67-year-old woman who ate vinegar in which this substance was used as a preservative (ACGIH (7th, 2001)). (4) It is described that this substance is unlikely to induce respiratory sensitization in humans but may cause symptoms of asthma in sensitive individuals (SIAR (2001), NICNAS IMAP (Accessed Dec. 2018)). [Reference Data, etc.] (5) In the announcement No. 316 of the Ministry of Health, Labour and Welfare (2013), this substance was designated as sodium metabisulfite in Simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (skin disorders, respiratory tract disorders) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare. (6) In humans, urticaria, asthma with itching, edema, rhinitis, and nasal congestion were reported for this substance, but it is pointed out that an immunological pathogenesis of these is not clear (SIAR (2001), NICNAS IMAP (Accessed Dec. 2018)). (7) It is reported that this substance is associated with work-related airway diseases (irritant-induced asthma, occupational asthma, vocal cord dysfunction with underlying asthma) in one trawlerman and two prawn processors, but it is suggested that it may be due to effects of sulfur dioxide, which is generated upon contact of this substance with water (Occup Med. 58 (8), 545-550 (2008)).
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Because there is knowledge that this substance is sensitizing in humans from (1)-(4), it was classified in Category 1. Besides, it is described in the minutes of the subcommittee on diseases due to chemical substances, Expert Committee of Article 35, the Ordinance for Enforcement of the Labor Standards Act (2013) that there are case reports on allergic contact dermatitis and asthma from occupational exposure to this substance, and onset of these is possible in normal workplaces. The category was revised from the previous one because new information was obtained. [Evidence Data] (1) A 50-year-old woman who sliced potato soaked in a stock solution in which this substance was used as a preservative, using unfit plastic gloves in a restaurant developed dermatitis and showed positive response in a patch test. It is reported that dermatitis gradually resolved after she was moved to another job in the same restaurant (Contact Dermatitis. 61 (4), 244-245 (2009)). (2) It is reported that in a patch test on 1,751 patients, 71 showed positive reactions, for 33 of which the association with this substance was specified but unknown for other 38 (HSDB (2011)). (3) It is reported that positive patch-testing and allergic contact dermatitis were observed in a few cases (SIAR (2001)). (4) It is reported that in a patch test on 980 eczematous patients, 14 showed positive reactions. Besides, it is written that this result does not meet the criteria for classification as a hazardous substance with respect to Sensitisation by Skin Contact according to the NICNAS Approved Criteria for Classifying Hazardous Substances (2005) (NICNAS IMAP (Accessed Dec. 2018)). [Reference Data, etc.] (5) In the announcement No. 316 of the Ministry of Health, Labour and Welfare (2013), this substance was designated as sodium metabisulfite in Simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (skin disorders, respiratory tract disorders) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare.
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	-	- -	-	-	-
7	Reproductive toxicity	-	- -	-	-	-
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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