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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	137-05-3
Chemical Name	Methyl 2-cyanoacrylate
Substance ID	H30-C-043-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2015 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Information suggesting Category 2 was obtained in (1)-(3), but information indicating "Not classified" was obtained in (4)-(6). Because conflicting results are reported, it was classified as "Classification not possible." [Evidence Data] (1) It was classified in Skin Irrit. 2 in EU CLP. (2) It is reported that in a skin irritation test with rabbits (Guideline 83/467/EC No. 8 (corresponding to OECD TG 404), n = 3), after 4-hour semi-occlusive application of undiluted this substance, irritation of erythema score: 3 and edema score: 1.5 was seen, and two out of three animals did not recover after 14 days (REACH registration dossier (Accessed Dec. 2018)). (3) It is described in CICAD that no conclusions can be drawn regarding whether allergic contact dermatitis from exposure to this substance and ethyl 2-cyanoacrylate was induced by an allergenic or irritation mechanism (CICAD (2001)). (4) It is reported that there is evidence that based on human data on this substance, single exposure is not irritating to the skin, but repeated exposure is irritating (CICAD (2001)). (5) It is reported that in a skin irritation test with rabbits (Code of Federal Regulations 191.11 (corresponding to OECD TG404), n = 3/group), after 24-hour occlusive application of undiluted this substance (purity 88.8%), skin irritation of erythema score: 0.33 was found after 72 hours (REACH registration dossier (Accessed Dec. 2018)). (6) It is reported that in a skin irritation test with rabbits, after 24-hour semi-occlusive application of undiluted this substance (purity about 100%), skin irritation of erythema score: 0.75 was observed after 72 hours, but there were no signs of edema (CICAD (2001)). [Reference Data, etc.] (7) In the announcement No. 33 of the Ministry of Labour (1996) (revised by the announcement No. 316 of the Ministry of Health, Labour and Welfare, 2013), this substance was designated as Simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (skin disorders, respiratory tract disorders, or mucous membrane irritation) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare. (8) In the notice No. 0811001 issued by Director of Labour Standards Bureau, the Ministry of Labour (2003), this substance was designated as the skin-damaging substance for which installation of protective equipment to prevent eye disorders such as protective glasses is mandated in Article 594 in the Industrial Safety and Health Regulations.
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	[Rationale for the Classification] Sufficient information on this substance alone to enable classification in respiratory sensitization was not obtained. However, because this substance is commonly used in a mixture with ethyl 2-cyanoacrylate, this substance was classified in Category 1 based on data (1) (2) and the assessment by ACGIH. [Evidence Data] (1) Many cases are reported in which adhesives containing this substance and ethyl 2-cyanoacrylate induced occupational asthma (ACGIH (2017), CICAD (2001)). (2) ACGIH judged this substance and ethyl 2-cyanoacrylate as respiratory sensitizers based on case reports from the past to the present (Lozewicz et al., 1985; Nakazawa, 1990; Quirce et al., 2001; Lindstrom et al., 2013), and it classified a group of this substance and ethyl 2-cyanoacrylate as RSEN and recommended warning industrial hygienists of the possibility that exposure to these substances at lower concentrations affects part of workers (ACGIH (2017)). [Reference Data, etc.] (3) It is described in CICAD that no conclusions can be drawn regarding whether asthma from exposure to this substance and ethyl 2-cyanoacrylate was induced by an allergenic or irritation mechanism (CICAD (2001)). (4) It is described in DFGOT: there is limited number of case reports in which adhesives containing this substance; ethyl 2-cyanoacrylate cause respiratory sensitization, if they exist, effects of combined exposure to cyanoacrylates have to be taken into account even if respiratory sensitization exists; the mechanism of action of cyanoacrylates is not clear; therefore, no conclusions can be drawn that they are sensitizing (DFGOT Vol. 13 (1999)).
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Sufficient information on this substance alone to enable classification in skin sensitization was not obtained. However, because this substance is commonly used in a mixture with ethyl 2-cyanoacrylate, this substance was classified in Category 1 based on data (1) (2) and the assessment by ACGIH. [Evidence Data] (1) Many cases are reported in which adhesives containing this substance and ethyl 2-cyanoacrylate induced allergic contact dermatitis (ACGIH (2017), CICAD (2001)). (2) Contact dermatitis and other symptoms were observed in 12 workers who set precious stones using this substance. Level measurement in a simulated work environment gave an air concentration of 0.4 ppm, and the possibility of irritative symptoms was ruled out because a ventilation system was installed (ACGIH (2017)). (3) ACGIH judged this substance and ethyl 2-cyanoacrylate as skin sensitizers based on case reports from the past to the present (Bruze et al., 1995; Conde-Salazar and Guimaraens, 1998; Constandt et al., 2005; Bhargava et al., 2012), and it classified a group of this substance and ethyl 2-cyanoacrylate as DSEN and recommended warning industrial hygienists of the possibility that exposure to these substances at lower concentrations affects part of workers (ACGIH (2017)). [Reference Data, etc.] (4) In the announcement No. 33 of the Ministry of Labour (1996) (revised by the announcement No. 316 of the Ministry of Health, Labour and Welfare, 2013), this substance was designated as Simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (skin disorders, respiratory tract disorders, or mucous membrane irritation) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare. (5) In the notice No. 0811001 issued by Director of Labour Standards Bureau, the Ministry of Labour (2003), this substance was designated as the skin-damaging substance for which installation of protective equipment to prevent eye disorders such as protective glasses is mandated in Article 594 in the Industrial Safety and Health Regulations. (6) It is reported that in skin a sensitization test with guinea pigs, this substance was not sensitizing (ACGIH (2017), CICAD (2001), REACH registration dossier (Accessed Dec. 2018)).
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	-	- -	-	-	-
7	Reproductive toxicity	-	- -	-	-	-
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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