Item | Information |
---|---|
CAS RN | 90-04-0 |
Chemical Name | o-Anisidine |
Substance ID | H30-C-045-MHLW |
Classification year (FY) | FY2018 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2009 FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases (including chemically unstable gases) | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (OECD TG404, GLP-compliant, n = 3), after 4-hour semi-occlusive application of undiluted this substance, erythema scores: 1 (2/3) and 0.7 (1/3) and a edema score: 0 were obtained after 72 hours, and animals fully recovered within 72 hours (DFGOT Vol.10 (1998), EU-RAR (2002), NICNAS IMAP (Accessed Dec. 2018), REACH registration dossier (Accessed Dec. 2018)). [Reference Data, etc.] (2) It is reported that in a skin irritation test with rabbits (n = 5), after 5-day open application of undiluted this substance, no irritation effects were seen after five days (REACH registration dossier (Accessed Dec. 2018)). |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[[Rationale for the Classification] It was classified in Category 1 from (1), (2). The category was revised from the previous classification by using new information sources. [Evidence Data] (1) It is reported: in an LLNA test with mice (OECD TG429, GLP-compliant, n = 4/group), after application of 25, 50, 100% solutions (DMSO) of this substance, SI values of 2.26 (25%), 3.43 (50%), 1.27 (100%) were obtained without dose-response relationship; one out of four animals died in a high-dose group, meaning that it is the dose where toxicity occurred; because an SI value was above 3 in a mid-dose group, the substance is regarded as sensitizing (REACH registration dossier (Accessed Dec. 2018)). (2) It is reported that in a maximization test with guinea pigs, after this substance was dosed at 0.5 and 2.5 mg/kg/week, it was weekly sensitizing (EU-RAR (2002), REACH registration dossier (Accessed Dec. 2018)). [Reference Data, etc.] (3) In the announcement No. 33 of the Ministry of Labour (1996) (revised by the announcement No. 316 of the Ministry of Health, Labour and Welfare, 2013), this substance was designated as "anisidine" in Simple chemical substances or compounds designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (subjective symptoms such as headaches, dizziness, and vomiting, and skin disorders, hemolytic anemia, or methemoglobinemia) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare. (4) In the notice No. 0811001 issued by Director of Labour Standards Bureau, the Ministry of Labour (2003), this substance was designated as "anisidine" among hazardous substances for which installation of protective equipment to prevent skin disorders is mandated in Article 594 in the Industrial Safety and Health Regulations. |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|