GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 5873-54-1
Chemical Name 2,4'-Diphenylmethane diisocyanate
Substance ID H30-C-048-MHLW
Classification year (FY) FY2018
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2013  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives -
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2 Flammable gases (including chemically unstable gases) -
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3 Aerosols -
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4 Oxidizing gases -
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5 Gases under pressure -
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6 Flammable liquids -
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7 Flammable solids -
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8 Self-reactive substances and mixtures -
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9 Pyrophoric liquids -
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10 Pyrophoric solids -
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11 Self-heating substances and mixtures -
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12 Substances and mixtures which, in contact with water, emit flammable gases -
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13 Oxidizing liquids -
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14 Oxidizing solids -
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15 Organic peroxides -
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16 Corrosive to metals -
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HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) -
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1 Acute toxicity (Dermal) -
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1 Acute toxicity (Inhalation: Gases) -
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1 Acute toxicity (Inhalation: Vapours) -
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1 Acute toxicity (Inhalation: Dusts and mists) -
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2 Skin corrosion/irritation -
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3 Serious eye damage/eye irritation Classification not possible
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- - [Rationale for the Classification]
Classification is not possible due to lack of data. Although there is information of (2)-(4), it was not used for the classification because it is information on isomer mixtures. Besides, an isomer mixture of this substance was classified in Category 2B in serious eye damage/eye irritation (please refer to CAS: 26447-40-5), and 4,4'-isomer was classified in Category 2B (please refer to CAS: 101-68-8).

[Reference Data, etc.]
(1) It was classified in Eye Irrit. 2 in EU CLP.
(2) Methylenediphenyl isocyanate (MDI) is known as an eye irritant (SIAR (2003), CICAD (2000)).
(3) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant, n = 3), after application of an undiluted isomer mixture containing this substance (2,2'-MDI: 0.64%, 2,4'-MDI: 53.60%, 4,4'-MDI: 45.72%), scores for corneal opacity, iris, conjunctival redness, and chemosis were 0 after 72 hours, and eye irritation was not seen (REACH registration dossier (Accessed Dec. 2018)).
(4) It is reported that in an eye irritation test with rabbit (n = 6), after application of an undiluted this substance (MDI isomer mixture, purity 92-95%), macroscopic observation showed no immediate change in the cornea, moderate conjunctivitis was found after 24 hours, and four out of six animals recovered within seven days while conjunctivitis persisted in the other two (REACH registration dossier (Accessed Dec. 2018)).
(5) As for methylenediphenyl isocyanate including 4,4'-isomer, skin disorders, anterior eye disorders, or respiratory tract disorders were designated as occupational diseases based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act.
4 Respiratory sensitization -
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4 Skin sensitization -
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5 Germ cell mutagenicity -
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6 Carcinogenicity -
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7 Reproductive toxicity -
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8 Specific target organ toxicity - Single exposure -
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9 Specific target organ toxicity - Repeated exposure -
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10 Aspiration hazard -
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ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
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11 Hazardous to the aquatic environment (Long-term) -
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12 Hazardous to the ozone layer -
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NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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