Item | Information |
---|---|
CAS RN | 128639-02-1 |
Chemical Name | Carfentrazone-ethyl |
Substance ID | R01-A-018 |
Classification year (FY) | FY2019 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | |
Model SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)." |
2 | Flammable gases | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
3 | Aerosols | * |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." |
4 | Oxidizing gases | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
5 | Gases under pressure | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
6 | Flammable liquids | * |
- |
- | - | It was classified as "Not classified" from a flash point of 299 deg C (ACGIH (7th, 2018)). |
7 | Flammable solids | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
8 | Self-reactive substances and mixtures | * |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)." |
9 | Pyrophoric liquids | * |
- |
- | - | No data available. |
10 | Pyrophoric solids | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
11 | Self-heating substances and mixtures | * |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | * |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)." |
13 | Oxidizing liquids | * |
- |
- | - | The substance is an organic compound containing oxygen, fluorine, and chlorine, which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)." |
14 | Oxidizing solids | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
15 | Organic peroxides | * |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)." |
16 | Corrosive to metals | * |
- |
- | - | No data available. |
17 | Desensitized explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | * |
- |
- | - |
[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: 5,143 mg/kg (ACGIH (7th, 2018), HSDB (Access on July 2019)) (2) LD50 for rats: > 5,000 mg/kg (EPA Pesticide (1998)) |
1 | Acute toxicity (Dermal) | * |
- |
- | - |
[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: > 4,000 mg/kg (ACGIH (7th, 2018), HSDB (Access on July 2019)) |
1 | Acute toxicity (Inhalation: Gases) | * |
- |
- | - |
[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
1 | Acute toxicity (Inhalation: Vapours) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | * |
- |
- | - |
[Rationale for the Classification] Based on (1), it was classified as "Not classified." Besides, since the LC50 value was higher than the saturated vapor concentration (0.000158 ppm), the reference value in units of mg/L was applied as a mist. [Evidence Data] (1) LC50 (4 hours) for rats: 5.09 mg/L (ACGIH (7th, 2018), HSDB (Access on July 2019)). |
2 | Skin corrosion/irritation | * |
- |
- | - |
[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) This substance was not irritating to the rabbit skin (ACGIH (7th, 2018), HSDB (Access on July 2019)). |
3 | Serious eye damage/eye irritation | * |
- |
- | - |
[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) This substance was minimally irritating to the rabbit eye (ACGIH (7th, 2018), HSDB (Access on July 2019)). |
4 | Respiratory sensitization | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | * |
- |
- | - |
[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) This substance was minimally irritating to the rabbit eye, however, it was nonirritating and nonsensitizing to the rabbit skin (ACGIH (7th, 2018), HSDB (Access on July 2019)). |
5 | Germ cell mutagenicity | * |
- |
- | - |
[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) As for in vivo, there are reports that it was negative in an erythrocyte micronucleus test and a hepatocyte unscheduled DNA synthesis test following intraperitoneal doses to mice (ACGIH (7th, 2018)). (2) As for in vitro, there are reports that it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (ACGIH (7th, 2018)). |
6 | Carcinogenicity | * |
- |
- | - |
[Rationale for the Classification] Based on the recent classification results by other organizations in (1), it was classified as "Classification not possible" in accordance with GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) According to existing classification results by domestic and international organizations, this substance was classified in A4 by ACGIH (ACGIH (7th, 2018)), and as NL (Not Likely to be Carcinogenic to Humans) by EPA (EPA Annual Cancer Report (2018): Classified in 2001). |
7 | Reproductive toxicity | * |
- |
- | - |
[Rationale for the Classification] Based on (1)-(3), it was classified as "Not classified." [Evidence Data] (1) In a 2-generation reproductive toxicity test with rats, reduced body weight gain was observed in parental animals of both generations, however, no reproductive toxicity was seen (ACGIH (7th, 2018)). (2) In a developmental toxicity test by oral administration of this substance to female rats from gestation Days 6 through 15, wavy and thickened ribs of fetuses were observed at the dose of maternal toxicity (urogenital staining) (ACGIH (7th, 2018)). Besides, effects on fetuses were thought to be skeletal variations. Effects on maternal animals were observed at or above 600 mg/kg/day, on the other hand, effects on fetuses were observed at 1,240 mg/kg/day, therefore, these results were determined as not evidence of classification. (3) In a developmental toxicity test by oral administration of this substance to female rabbits from gestation Days 6 through 19, no effects on maternal animals or fetuses were observed (ACGIH (7th, 2018)). |
8 | Specific target organ toxicity - Single exposure | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver) |
Warning |
H373 |
P260
P314 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 2 (liver). [Evidence Data] (1) In a 2-year combined repeated dose toxicity/carcinogenicity test with rats by feeding, increases in total urinary porphyrins and liver toxicity were reported at or above doses within the range for Category 2 (male: 37 mg/kg/day, female: 12 mg/kg/day) (ACGIH (7th, 2018)). (2) In a feeding carcinogenicity test with mice, increased mortality and hepatocellular damage were reported at doses within or above the range for Category 2 (male: 100 mg/kg/day, female: 119 mg/kg/day) (ACGIH (7th, 2018)). [Reference Data, etc.] (3) In a 1-year feeding repeated dose toxicity test with dogs, an increase in urinary porphyrins at a dose of 150 mg/kg/day (exceeding the range for Category 2) is reported (ACGIH (7th, 2018)). (4) In a 90-day feeding repeated dose toxicity test with mice, liver pathology was reported at or above 1,143 mg/kg/day (exceeding the range for Category 2) (ACGIH (7th, 2018)). (5) In a 90-day feeding repeated dose toxicity test with rats, decreased rates of body weight gain, reductions in food consumption and histopathologic changes in the liver at doses exceeding the range for Category 2 (male: 470 mg/kg/day, female: 578 mg/kg/day) were reported (ACGIH (7th, 2018)). (6) In a 90-day feeding repeated dose toxicity test with dogs, a decreased rate of body weight gain in females and an increase in urinary porphyrins in both sexes were reported at or above 150 mg/kg/day (exceeding the range for Category 2) (ACGIH (7th, 2018)). |
10 | Aspiration hazard | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 72-hour ErC50 = 0.0139 mg/L for algae (Pseudokirchneriella subcapitata) (Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2014). |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN), and 72-hour NOECr = 0.00497 mg/L for algae (Pseudokirchneriella subcapitata) (Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2014). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (BIOWIN), and 96-hour LC50 = 3.29 mg/L for fish (Cyprinus carpio) (Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2014). By drawing a comparison between the above results, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
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