GHS Classification Results by the Japanese Government

日本語で表示



GENERAL INFORMATION
Item Information
CAS RN 128639-02-1
Chemical Name Carfentrazone-ethyl
Substance ID R01-A-018
Classification year (FY) FY2019
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link)  
Model SDS by MHLW (External link)  
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2 Flammable gases *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
3 Aerosols *
-
-
- - Not aerosol products. It was classified as "Not classified (Not applicable)."
4 Oxidizing gases *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
5 Gases under pressure *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
6 Flammable liquids *
-
-
- - It was classified as "Not classified" from a flash point of 299 deg C (ACGIH (7th, 2018)).
7 Flammable solids *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
8 Self-reactive substances and mixtures *
-
-
- - There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)."
9 Pyrophoric liquids *
-
-
- - No data available.
10 Pyrophoric solids *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
11 Self-heating substances and mixtures *
-
-
- - Classification is not possible because test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases *
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."
13 Oxidizing liquids *
-
-
- - The substance is an organic compound containing oxygen, fluorine, and chlorine, which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)."
14 Oxidizing solids *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
15 Organic peroxides *
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."
16 Corrosive to metals *
-
-
- - No data available.
17 Desensitized explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) *
-
-
- - [Rationale for the Classification]
Based on (1) and (2), it was classified as "Not classified."

[Evidence Data]
(1) LD50 for rats: 5,143 mg/kg (ACGIH (7th, 2018), HSDB (Access on July 2019))
(2) LD50 for rats: > 5,000 mg/kg (EPA Pesticide (1998))
1 Acute toxicity (Dermal) *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) LD50 for rats: > 4,000 mg/kg (ACGIH (7th, 2018), HSDB (Access on July 2019))
1 Acute toxicity (Inhalation: Gases) *
-
-
- - [Rationale for the Classification]
Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
1 Acute toxicity (Inhalation: Vapours) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."
Besides, since the LC50 value was higher than the saturated vapor concentration (0.000158 ppm), the reference value in units of mg/L was applied as a mist.

[Evidence Data]
(1) LC50 (4 hours) for rats: 5.09 mg/L (ACGIH (7th, 2018), HSDB (Access on July 2019)).
2 Skin corrosion/irritation *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) This substance was not irritating to the rabbit skin (ACGIH (7th, 2018), HSDB (Access on July 2019)).
3 Serious eye damage/eye irritation *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) This substance was minimally irritating to the rabbit eye (ACGIH (7th, 2018), HSDB (Access on July 2019)).
4 Respiratory sensitization *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) This substance was minimally irritating to the rabbit eye, however, it was nonirritating and nonsensitizing to the rabbit skin (ACGIH (7th, 2018), HSDB (Access on July 2019)).
5 Germ cell mutagenicity *
-
-
- - [Rationale for the Classification]
Based on (1) and (2), it was classified as "Not classified."

[Evidence Data]
(1) As for in vivo, there are reports that it was negative in an erythrocyte micronucleus test and a hepatocyte unscheduled DNA synthesis test following intraperitoneal doses to mice (ACGIH (7th, 2018)).
(2) As for in vitro, there are reports that it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (ACGIH (7th, 2018)).
6 Carcinogenicity *
-
-
- - [Rationale for the Classification]
Based on the recent classification results by other organizations in (1), it was classified as "Classification not possible" in accordance with GHS Classification Guidance for the Japanese Government.

[Evidence Data]
(1) According to existing classification results by domestic and international organizations, this substance was classified in A4 by ACGIH (ACGIH (7th, 2018)), and as NL (Not Likely to be Carcinogenic to Humans) by EPA (EPA Annual Cancer Report (2018): Classified in 2001).
7 Reproductive toxicity *
-
-
- - [Rationale for the Classification]
Based on (1)-(3), it was classified as "Not classified."

[Evidence Data]
(1) In a 2-generation reproductive toxicity test with rats, reduced body weight gain was observed in parental animals of both generations, however, no reproductive toxicity was seen (ACGIH (7th, 2018)).
(2) In a developmental toxicity test by oral administration of this substance to female rats from gestation Days 6 through 15, wavy and thickened ribs of fetuses were observed at the dose of maternal toxicity (urogenital staining) (ACGIH (7th, 2018)). Besides, effects on fetuses were thought to be skeletal variations. Effects on maternal animals were observed at or above 600 mg/kg/day, on the other hand, effects on fetuses were observed at 1,240 mg/kg/day, therefore, these results were determined as not evidence of classification.
(3) In a developmental toxicity test by oral administration of this substance to female rabbits from gestation Days 6 through 19, no effects on maternal animals or fetuses were observed (ACGIH (7th, 2018)).
8 Specific target organ toxicity - Single exposure *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver)


Warning
H373 P260
P314
P501
[Rationale for the Classification]
Based on (1), it was classified in Category 2 (liver).

[Evidence Data]
(1) In a 2-year combined repeated dose toxicity/carcinogenicity test with rats by feeding, increases in total urinary porphyrins and liver toxicity were reported at or above doses within the range for Category 2 (male: 37 mg/kg/day, female: 12 mg/kg/day) (ACGIH (7th, 2018)).
(2) In a feeding carcinogenicity test with mice, increased mortality and hepatocellular damage were reported at doses within or above the range for Category 2 (male: 100 mg/kg/day, female: 119 mg/kg/day) (ACGIH (7th, 2018)).

[Reference Data, etc.]
(3) In a 1-year feeding repeated dose toxicity test with dogs, an increase in urinary porphyrins at a dose of 150 mg/kg/day (exceeding the range for Category 2) is reported (ACGIH (7th, 2018)).
(4) In a 90-day feeding repeated dose toxicity test with mice, liver pathology was reported at or above 1,143 mg/kg/day (exceeding the range for Category 2) (ACGIH (7th, 2018)).
(5) In a 90-day feeding repeated dose toxicity test with rats, decreased rates of body weight gain, reductions in food consumption and histopathologic changes in the liver at doses exceeding the range for Category 2 (male: 470 mg/kg/day, female: 578 mg/kg/day) were reported (ACGIH (7th, 2018)).
(6) In a 90-day feeding repeated dose toxicity test with dogs, a decreased rate of body weight gain in females and an increase in urinary porphyrins in both sexes were reported at or above 150 mg/kg/day (exceeding the range for Category 2) (ACGIH (7th, 2018)).
10 Aspiration hazard *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) Category 1


Warning
H400 P273
P391
P501
It was classified in Category 1 from 72-hour ErC50 = 0.0139 mg/L for algae (Pseudokirchneriella subcapitata) (Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2014).
11 Hazardous to the aquatic environment Long term (Chronic) Category 1


Warning
H410 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN), and 72-hour NOECr = 0.00497 mg/L for algae (Pseudokirchneriella subcapitata) (Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2014).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (BIOWIN), and 96-hour LC50 = 3.29 mg/L for fish (Cyprinus carpio) (Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2014).
By drawing a comparison between the above results, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- - Classification not possible due to lack of data.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information