GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 105-39-5
Chemical Name Ethyl chloroacetate
Substance ID R01-B-015
Classification year (FY) FY2019
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2018   FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2 Flammable gases *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
3 Aerosols *
-
-
- - Not aerosol products. It was classified as "Not classified (Not applicable)."
4 Oxidizing gases *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
5 Gases under pressure *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
6 Flammable liquids Category 3


Warning
H226 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
It was classified in Category 3 based on a flash point of 53 deg C (closed cup) (ICSC (2001)). Besides, it is classified in Division 6.1, Subsidiary Risk 3, PG II in UNRTDG (UN1181).
7 Flammable solids *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
8 Self-reactive substances and mixtures *
-
-
- - There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)."
9 Pyrophoric liquids *
-
-
- - It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 452 deg C (ICSC (2001)).
10 Pyrophoric solids *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
11 Self-heating substances and mixtures *
-
-
- - Classification is not possible because test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases *
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."
13 Oxidizing liquids *
-
-
- - The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)."
14 Oxidizing solids *
-
-
- - Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
15 Organic peroxides *
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."
16 Corrosive to metals *
-
-
- - No data available.
17 Desensitized explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 3


Danger
H301 P301+P310
P264
P270
P321
P330
P405
P501
[Rationale for the Classification]
Based on (1), it was classified in Category 3.

[Evidence Data]
(1) LD50 for rats: 180 mg/kg (BUA 263 (2007))
1 Acute toxicity (Dermal) Category 2


Danger
H310 P302+P352
P361+P364
P262
P264
P270
P280
P310
P321
P405
P501
[Rationale for the Classification]
Based on (1), it was corresponding to Category 2 for rats, and based on (2)-(4), it was corresponding to Category 3 for rabbits. Therefore, it was conservatively classified in Category 2.

[Evidence Data]
(1) LD50 for rats: 161 mg/kg (BUA 263 (2007))
(2) LD50 for rabbits: 230 mg/kg (BUA 151 (1993), HSDB (Access on June 2019))
(3) LD50 for rabbits: 335 mg/kg (BUA 151 (1993))
(4) LD50 for rabbits: 230-335 mg/kg (BUA 263 (2007))
1 Acute toxicity (Inhalation: Gases) *
-
-
- - [Rationale for the Classification]
Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
1 Acute toxicity (Inhalation: Vapours) Category 3


Danger
H331 P304+P340
P403+P233
P261
P271
P311
P321
P405
P501
[Rationale for the Classification]
Based on (1), it was classified in Category 3.
Since the LC50 value was lower than 90% of the saturated vapor concentration (6408.4 ppm), the reference value in units of ppm was applied as a vapor without a mist.
Besides, the category was changed from the previous classification by the use of the new information sources.

[Evidence Data]
(1) LC50 (4 hours) for rats: 3.81 mg/L (760.13 ppm) (GESTIS (Access on July 2019))
1 Acute toxicity (Inhalation: Dusts and mists) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
[Rationale for the Classification]
Since effects were judged to be non-reversible based on (1), it was classified in Category 1. Besides, the category was changed due to the detailed information obtained.

[Evidence Data]
(1) In a skin irritation test with rabbits according to OECD TG 404, the mean scores at 24/48/72 hours were 3-3.67 for erythema and 3.3 for edema. Erythema of 2/3 animals was not fully reversible in 21 days (REACH registration dossier (Access on July 2019)).

[Reference Data, etc.]
(2) As for a human case, a worker had the back of his hand and his forearm exposed to a 1.5 M solution (M/ethanol) of this substance, and reddening and blistering of the skin developed in 1 hour. The lesions healed within 10 days, leaving small scars (GESTIS (Access on June 2019)).
(3) In a skin irritation test in which this substance was administered to rabbits by semi-occlusive application for 4 hours, slight to severe erythema by 14 days and very slight to severe edema by 7 days were observed. The reactions were considered to be reversible, and it was judged as an irritant (BUA 151 (1993)).
(4) This substance is toxic by ingestion, inhalation and skin absorption and is a strong irritant and a lacrimator (NTP DB (Access on June 2019)). It was classified as "Skin Irrit. 2 (H315)" in the EU-CLP classification (EU CLP classification (Access on August 2019)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
[Rationale for the Classification]
Since it was judged to be a skin irritant (Category 1) based on (1), it was classified in Category 1. Besides, the category was changed due to the new information obtained.

[Evidence Data]
(1) In a skin irritation test with rabbits according to OECD TG 404, the mean scores at 24/48/72 hours were 3-3.67 for erythema and 3.3 for edema. Erythema of 2/3 animals was not fully reversible in 21 days. Therefore, it was classified in "Skin Category 1 (corrosion)" (REACH registration dossier (Access on July 2019)).

[Reference Data, etc.]
(2) In an eye irritation test with rabbits, it was judged to be a strong eye irritant (BUA 151 (1993)).
(3) There is a description that it is strongly irritating to humans (HSDB (Access on June 2019)).
4 Respiratory sensitization *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1.

[Evidence Data]
(1) It is described that it strongly sensitized animals in a skin sensitization test with guinea pigs (maximization test) (BUA 151 (1993)).
(2) It is described that 5/20 animals were sensitized (positive rate 25%) in a skin sensitization test with guinea pigs according to OECD TG 406 (BUA 151 (1993), REACH registration dossier (Access on July 2019)).

[Reference Data, etc.]
(3) There was a report of a positive reaction to this substance in a patch test in humans (GESTIS (Access on June 2019)).
(4) There was a report on cross-reactivity to chloroacetic acid methyl ester in a skin sensitization test with guinea pigs on this substance (GESTIS (Access on June 2019)).
5 Germ cell mutagenicity *
-
-
- - [Rationale for the Classification]
There are no in vivo data. Therefore, classification was not possible due to lack of data.

[Evidence Data]
(1) As for in vitro, there was a report of a negative result in a bacterial reverse mutation test (NTP DB (Access on June 2019)).
6 Carcinogenicity *
-
-
- - [Rationale for the Classification]
There are no classifications by other organizations. Therefore, classification was not possible due to lack of data.

[Reference Data, etc.]
(1) Tumorigenic was not observed in a subcutaneous injection of this substance to mice (NTP DB (Access on June 2019)).
(2) An equivocal result for induction of lung adenomas was obtained by an intraperitoneal injection of this substance to strain A mice (NTP DB (Access on June 2019)).
7 Reproductive toxicity *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs), Category 3 (narcotic effects)



Danger
Warning
H370
H336
P308+P311
P260
P264
P270
P321
P405
P501
P304+P340
P403+P233
P261
P271
P312
[Rationale for the Classification]
Based on (1) and (2), since effects on the respiratory organs and central nervous system were observed, it was classified in Category 1 (respiratory organs), Category 3 (narcotic effects). The classification results were changed from the previous classification by the use of the new information sources.

[Evidence Data]
(1) The major consequence after inhalation exposure to this substance was considered to be the risk of severe lung damage. Moreover, narcosis was also one of the highlighted effects (GESTIS (Access on June 2019)).
(2) In a 4-hour single inhalation exposure test with rats, at 0.83-7.5 mL/m3 (converted value based on the density, 1.15 g/cm3: 0.95-8.63 g/m3 = 0.95-8.63 mg/L) of the aerosol of this substance, increased respiratory rate, irregular breathing, panting, tremor, balance disorder, ataxia, drowsiness, analgesia and hyporeflexia were observed (REACH registration dossier (Access on September 2019)).

[Reference Data, etc.]
(3) Despite no descriptions of whether effects were observed in humans or experimental animals, there was a description that pronounced systemic effects such as drowsiness, vertigo, hyporeflexia and respiratory disorders were observed after application of even minor doses (GESTIS (Access on June 2019)).
9 Specific target organ toxicity - Repeated exposure *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
10 Aspiration hazard *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment Long term (Chronic) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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