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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	107-11-9
Chemical Name	3-Amino-1-propene; Allylamine
Substance ID	R01-B-018
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2018 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of -29 deg C (closed cup) and a boiling point of 52-53 deg C (Hommel (1991)).
7	Flammable solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
8	Self-reactive substances and mixtures	*	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	*	- -	-	-	It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 370 deg C (Hommel (1991)).
10	Pyrophoric solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
11	Self-heating substances and mixtures	*	- -	-	-	Classification is not possible because test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."
13	Oxidizing liquids	*	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine. It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to low-temperature-boiling liquids are not available.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 3. [Evidence Data] (1) LD50 for rats: 102 mg/kg (PATTY (6th, 2012), HSDB (Access on June 2019)) (2) LD50 for rats: 106 mg/kg (HSDB (Access on June 2019))
1	Acute toxicity (Dermal)	Category 1	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	[Rationale for the Classification] Base on (1), it was classified in Category 1. [Evidence Data] (1) LD50 for rabbits: 35 mg/kg (PATTY (6th, 2012), HSDB (Access on June 2019))
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 2. Besides, LC50 values were lower than 90% of the saturated vapor concentration (318,446 ppm), therefore, the reference value in units of ppm was applied as vapour with little mist. [Evidence Data] (1) LC50 for rats (4 hours): 286 ppm (PATTY (6th, 2012), HSDB (Access on June 2019)) [Reference Data, etc.] (2) LC50 for rats (8 hours): 177 ppm (converted 4-hour equivalent value: 250.32 ppm) (PATTY (6th, 2012))
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1. Besides, since new data were obtained, the category was changed. [Evidence Data] (1) In an in vitro skin corrosion test using an artificial skin model (EpiDerm) in accordance with OECD TG 431, after 3 or 60 minutes of exposure, the viability was 12.8% or 8.4%, respectively (REACH registration dossier (Access on July 2019)). [Reference Data, etc.] (2) This substance is a severe eye and skin irritant (PATTY (6th, 2012)). (3) This substance is a severe skin and eye irritant in humans (HSDB (Access on June 2019)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on data of (1)-(4) and the fact that it was judged to be skin corrosive (Category 1), it was classified in Category 1. Besides, since detailed data was obtained, the category was changed. [Evidence Data] (1) This substance is a severe eye and skin irritant (PATTY (6th, 2012)). (2) This substance is a severe skin and eye irritant in humans (HSDB (Access on June 2019)). (3) There is a report that in an eye irritation test with rabbits, equivalent or similar to OECD TG 405 (applied with 0.05 mL), it was highly irritating (REACH registration dossier (Access on July 2019)). (4) In an in vitro skin corrosion test using an artificial skin model (EpiDerm) in accordance with OECD TG 431, it was judged to be a corrosive substance (Category 1) (REACH registration dossier (Access on July 2019)). [Reference Data, etc.] (5) In the case of accidental exposure to the vapors of this substance, transient irritation to the mucous membranes of the nose, eyes and mouth occurred, resulting in lacrimation, coryza and sneezing (PATTY (6th, 2012)).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] There are no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, there is a negative result in a bacterial reverse mutation test (NTP DB (Access on June 2019)).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Although no reproductive toxicity was observed in (1), this test is a screening test and there are no data from developmental toxicity tests, therefore, classification is not possible due to lack of data. [Evidence Data] (1) In a reproduction/developmental toxicity screening test with rats exposed by inhalation (OECD TG 421), no reproductive toxicity was observed at concentrations where parental toxicity (underactivity, piloerection, hunched posture and decreased body weight gain) was observed (REACH registration dossier (Access on July 2019)).
8	Specific target organ toxicity - Single exposure	Category 1 (cardiovascular system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	[Rationale for the Classification] Based on human exposure cases in (1)-(3) and the results in rats in (4), it was classified in Category 1 (cardiovascular system), Category 3 (respiratory tract irritation). Although the lung was included as a target organ in the previous classification, the original source was listed in List 3 and there is no other supporting information, therefore, the classification result was changed. [Evidence Data] (1) Mucous membrane irritation and chest discomfort occurred in some persons after inhalation of this substance at 2.5 ppm (PATTY (6th, 2012), HSDB (Access on June 2019)). (2) Inhalation of the vapors of this substance at 14 ppm caused intolerable irritation of the eyes and respiratory tract in humans (HSDB (Access on June 2019)). (3) Researchers (several) exposed to the vapor (concentration unknown) of this substance by an accident experienced transient irritation of the mucous membranes of the nose, eyes, and mouth, with lacrimation, coryza, and sneezing (PATTY (6th, 2012), HSDB (Access on June 2019)). (4) In a single inhalation exposure test with rats, perivascular edema and cellular infiltration were observed in the heart after 4-hour exposure at 100 ppm (corresponding to Category 1), and an obvious myocardial lesion was confirmed in one animal (NRC Committee on AEGL (2007)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (cardiovascular system)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1), effects on the cardiac muscle and blood vessels were observed after oral administration to rats, therefore, it was classified in Category 1 (cardiovascular system). Since information sources were reviewed, the classification result was changed from the previous classification. [Evidence Data] (1) In a study in which male rats were administered 0.005 to 0.1% of this substance in drinking water for 21-104 days, it caused dose-dependent myocardial and vascular lesions, and after three weeks of treatment (converted guidance value: 1.5-29 mg/kg/day, within the range of Category 1-Category 2), severe myocardial fibrosis was developed (PATTY (6th, 2012), HSDB (Access on June 2019)). [Reference Data, etc.] (2) In a study in which localized arteritis was observed following intradermal injection of this substance, cardiotoxicity was reported (PATTY (6th, 2012)). (3) Allylamines are known to be cardiotoxins. They can cause acute myocardial necrosis that is cumulative with repeated administrations, as well as vascular proliferative lesions after several weeks of treatment (PATTY (6th, 2012)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. Besides, although there is information of (1), no other information is available to provide the evidence of the classification, therefore, it was classified as "Classification not possible" due to lack of data. [Reference Data, etc.] (1) Although there is a possibility of pneumonia due to aspiration in humans (SITTIG (6th, 2012)), no other information is available to provide the evidence of the classification, therefore, classification is not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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