NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	542-92-7
Chemical Name	Cyclopentadiene
Substance ID	R01-B-025
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2014 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	There are data: a flash point of 25 deg C (open cup) (ICSC (1996)), a boiling point of 41 deg C (HSDB (Access on July 2019)), which correspond to Category 2 or Category 3 in the prescribed closed-cup method. It was classified in Category 2 by adopting the safe side.
7	Flammable solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
8	Self-reactive substances and mixtures	*	- -	-	-	There is an olefin, a chemical group associated with self-reactive properties, present in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	*	- -	-	-	It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 640 deg C (ICSC (1996)).
10	Pyrophoric solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
11	Self-heating substances and mixtures	*	- -	-	-	Classification is not possible because test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)."
13	Oxidizing liquids	*	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine. It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to low-temperature-boiling liquids are not available.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 3. [Evidence Data] (1) LD50 for rats: 113 mg/kg (GESTIS (Access on July 2019))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 3. [Evidence Data] (1) LD50 for rabbits: 430 mg/kg (GESTIS (Access on July 2019))
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	[Rationale for the Classification] Based on (1), it was classified in Category 4. Besides, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (about 572,413.6 ppm), a reference value in the unit of ppm was applied as a vapor with little mist. [Evidence Data] (1) LC50 (1 hour) for rats: 14,425.9 ppm (converted 4-hour equivalent value: 7,212.95 ppm) (PATTY (6th, 2012), HSDB (Access on June 2019)) [Reference Data, etc.] (2) LC50 (1 hour) for mice: 5,548.4 ppm (converted 4-hour equivalent value: 2,274.2 ppm) (PATTY (6th, 2012), HSDB (Access on June 2019))
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	[Rationale for the Classification] Based on (1), it was classified in Category 2. Besides, the category was changed due to the new data obtained. [Evidence Data] (1) This substance caused contact dermatitis and sensitization (PATTY (6th, 2012)).
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	[Rationale for the Classification] Based on (1), it was classified in Category 2. Besides, the category was changed due to the new data obtained. [Evidence Data] (1) This substance is irritating to the eyes and mucous membranes (PATTY (6th, 2012)).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1. [Reference Data, etc.] (1) This substance caused contact dermatitis and sensitization (PATTY (6th, 2012)).
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	[Rationale for the Classification] Based on (1) and (2), it was irritating to the respiratory tract in humans. Based on (3), effects on the central nervous system and respiratory organs were observed at the dose corresponding to Category 1 in experimental animals. Therefore, it was classified in Category 1 (respiratory organs), Category 3 (narcotic effects). The category was changed from the previous classification by the use of the new information. [Evidence Data] (1) As for humans, subjects detected an irritating and objectionable odor at 250 ppm and 500 ppm (ACGIH (7th, 2001)). (2) There is a description that this substance is irritating to the eyes and mucous membranes (PATTY (6th, 2012)). (3) In a 6-hour single inhalation exposure test with mice, respiratory disorders, central nervous system symptoms (reduced activity, coordination disorders) were observed by exposure to the vapor of this substance at 2 mg/L (converted 4-hour equivalent value: 2.45 mg/L, corresponding to Category 1) (GESTIS (Access on June 2019)). [Reference Data, etc.] (4) This substance dimerizes into dicyclopentadiene (CAS RN 77-73-6) (ACGIH (7th, 2019)). As for dicyclopentadiene, there is a report that in a 4-hour single inhalation exposure test with rats at 1,000 ppm (5.4 mg/L, corresponding to Category 1), irritation of the eyes and nose, dyspnea, muscular incoordination, tremor and hypersensitivity were observed, and all animals died later (DFGOT vol.5 (1993), ACGIH (7th, 2019)). Dicyclopentadiene was classified in Category 1 (central nervous system, respiratory organs), Category 3 (narcotic effects) in the GHS classification in FY 2017.
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, kidney)	Warning	H373	P260 P314 P501	[Rationale for the Classification] Based on (1), it was classified in Category 2 (liver, kidney). [Evidence Data] (1) As a result of a total of 35 exposures of rats to this substance at a mean concentration of 500 ppm (converted guidance value: 0.6 mg/L, within the range of Category 2) for 53 days (7 hours/day), mild centrilobular cloudy swelling of the liver cells and vacuolization of the renal tubular epithelium were observed (PATTY (6th, 2012)). [Reference Data, etc.] (2) Since this substance dimerizes into dicyclopentadiene, ACGIH recommended using the TLV for dicyclopentadiene if this substance is concerned (ACGIH (7th, 2019)). (3) As for dicyclopentadiene, the dimer of this substance, as a result of exposures of rats by inhalation to the vapor for 89 days (7 hours/day, 5 days/week), renal effects were observed at or above 35.2 ppm (converted guidance value: 0.1 mg/L, within the range of Category 1), and chronic pneumonia and bronchiectasis were observed at 73.8 ppm (converted guidance value: 0.2 mg/L, within the range of Category 1). As a result of exposures of mice by inhalation to the vapor for 13 weeks (6 hours/day, 5 days/week), deaths (19/90 animals) were observed at 50 ppm (converted guidance value: 0.1 mg/L, within the range of Category 1), many of them were attributed to pulmonary congestion likely due to the result of pulmonary irritation, and two animals died of renal failure (ACGIH (7th, 2019)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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