GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 10026-13-8
Chemical Name Phosphorus pentachloride
Substance ID R01-B-032
Classification year (FY) FY2019
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link)  
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2 Flammable gases *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3 Aerosols *
-
-
- - Not aerosol products. It was classified as "Not classified (Not applicable)."
4 Oxidizing gases *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5 Gases under pressure *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6 Flammable liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7 Flammable solids *
-
-
- - It was classified as "Not classified" from information that it is not combustible (Hommel (1991)).
8 Self-reactive substances and mixtures *
-
-
- - There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)."
9 Pyrophoric liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10 Pyrophoric solids *
-
-
- - It was classified as "Not classified" from information that it is not combustible (Hommel (1991)).
11 Self-heating substances and mixtures *
-
-
- - It was classified as "Not classified" from information that it is not combustible (Hommel (1991)).
12 Substances and mixtures which, in contact with water, emit flammable gases *
-
-
- - It reacts vigorously with water, and there are severe heating and decomposition to form corrosive phosphoric acid and hydrochloric acid (Hommel (1991)), both of which are not combustible. Therefore, it was classified as "Not classified."
13 Oxidizing liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14 Oxidizing solids *
-
-
- - It is an inorganic compound containing halogen (Cl) (but not oxygen), but the classification is not possible due to no data.
15 Organic peroxides *
-
-
- - Inorganic substance. It was classified as "Not classified (Not applicable)."
16 Corrosive to metals *
-
-
- - Classification is not possible because test methods applicable to solid substances are not available.
17 Desensitized explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
[Rationale for the Classification]
Based on (1), it was classified in Category 4.

[Evidence Data]
(1) LD50 for rats: about 600 mg/kg (REACH registration dossier (Access on August 2019))
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
[Rationale for the Classification]
Based on (1), it was classified in Category 3.
Besides, the category was changed from the previous classification by the use of new information sources.

[Evidence Data]
(1) LD50 for rabbits: 660 mg/kg (HSDB (Access on July 2019))
1 Acute toxicity (Inhalation: Gases) *
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1 Acute toxicity (Inhalation: Vapours) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
(1) LC50 for rats (dusts, Exposure time is unknown): 0.205 mg/L (REACH registration dossier (Access on August 2019))
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1.

[Evidence Data]
(1) This substance is irritating to the skin, eyes and respiratory organs (HSDB (Access on July 2019)).
(2) It is reported that this substance is severely irritating or corrosive to the mucous membranes and skin in humans (GESTIS (Access on August 2019)).

[Reference Data, etc.]
(3) It was classified as "Skin Corr. 1B (H314)" in the EU CLP classification (EU CLP classification (Access on July 2019)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
[Rationale for the Classification]
Based on (1)-(4), it was classified in Category 1.

[Evidence Data]
(1) Based on a report that this substance causes severe irritation or corrosion to the mucous membranes and skin of humans (GESTIS (Access on August 2019)), it was classified in skin corrosion (Category 1).
(2) There is a description that the fumes of this substance cause irritation of the eyes (ACGIH (7th, 2001), HSDB (Access on July 2019)).
(3) There is a description that the vapor or fume of this substance is very irritating to all mucous membranes (PATTY (6th, 2012)).
(4) This substance is irritating to the skin, eyes and respiratory organs (HSDB (Access on July 2019)).
4 Respiratory sensitization *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
5 Germ cell mutagenicity *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
6 Carcinogenicity *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
7 Reproductive toxicity *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
[Rationale for the Classification]
Based on (1)-(3), it was classified in Category 1 (respiratory organs). The circulatory system also was adopted as a target organ in the previous classification, based on descriptions in HSDB (2005) adopted as evidence. However, these were described as general effects from various acids in HSDB (Access on July 2019), and it was unknown whether it was due to the effect of this substance alone. Since there was no other information to support the effects on the circulatory organ system, the classification result was changed.

[Evidence Data]
(1) There is a report that the fumes of this substance caused irritation of the eyes and respiratory passages, and that exposure caused cases of bronchitis (ACGIH (7th, 2001)).
(2) The vapor or fume of this substance is very irritating to all mucous surfaces including the lungs (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989), PATTY (6th, 2012)).
(3) As for humans, it was reported that the vapor of this substance caused irritation to the eyes and respiratory tract, and that secretion from the nose, cough, pain in the throat and difficulties in breathing as well as pulmonary edema were observed in some cases (GESTIS (Access on July 2019)).

[Reference Data, etc.]
(4) Under moisture in the air, this substance hydrolyzes to generate hydrogen chloride (CAS RN 7647-01-0) and phosphoric acid (CAS RN 7664-38-2) (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989), GESTIS (Access on July 2019)). Both hydrogen chloride and phosphoric acid are corrosive and irritating, and the effects on the respiratory organs were reported (hydrogen chloride: SIDS (2005), phosphoric acid: SIDS (2011)).
9 Specific target organ toxicity - Repeated exposure Category 2 (bone)


Warning
H373 P260
P314
P501
[Rationale for the Classification]
Based on (1), it is considered that inhalation causes effects on the bone in humans. Since it was information on phosphorus and phosphorus compounds, not this substance itself, it was classified in Category 2 (bone).

[Evidence Data]
(1) Chronic inhalation of phosphorus and chloro compounds of phosphorus causes damage to bony tissue in humans (HSDB (Access on July 2019)).

[Reference Data, etc.]
(2) In experimental animals, chronic exposure to the oxychloride, trichloride and pentachloride of phosphorus caused morphologic changes of the liver, bone, kidneys and lungs. Moreover, pathological examination in the respiratory passages resulted in desquamative rhinitis, tracheitis and bronchitis (HSDB (Access on July 2019)).
10 Aspiration hazard *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment Long term (Chronic) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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