NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	121-45-9
Chemical Name	Trimethyl phosphite
Substance ID	R01-B-036
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 3 based on a flash point of 28 deg C (closed cup) (Hommel (1991)). It is classified in Class 3, PG III in UNRTDG (UN2329).
7	Flammable solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (P-O) present in the molecule, but it is classified in Class 3, PG II in UNRTDG (UN2329). Self-reactive substances and mixtures, hazards of the highest precedence, were classified as Type G according to the GHS classification guidance for the Japanese government.
9	Pyrophoric liquids	*	- -	-	-	It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 250 deg C (ICSC (2004)).
10	Pyrophoric solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
11	Self-heating substances and mixtures	*	- -	-	-	Classification is not possible because test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	It contains a metalloid (P), but the classification is not possible due to no data. Besides, there is the information that it reacts vigorously with water with severe heating and has an explosion risk (Hommel (1991)).
13	Oxidizing liquids	*	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to an element (P) other than carbon or hydrogen. However, the classification is not possible due to no data.
14	Oxidizing solids	*	- -	-	-	Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	No data available.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 4. Besides, the category was changed from the previous classification due to the addition of new information sources. [Evidence Data] (1) LD50 for rats: > 2,000 mg/kg (JECDB (Access on August 2019)) (2) LD50 for rats: 2,500-2,890 mg/kg (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on June 2019)) (3) LD50 for rats: 1,600 mg/kg (PATTY (6th, 2012), HSDB (Access on June 2019))
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." Besides, the category was changed from the previous classification according to the revised GHS classification guidance for the Japanese government. [Evidence Data] (1) LD50 for rabbits: 2,600 mg/kg (ACGIH (7th, 2001), HSDB (Access on June 2019))
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Classification could not be specified based on (1). Therefore, it was classified as "Classification not possible." Besides, since the LC50 value was lower than 90% of the saturated vapor pressure concentration (about 31,581.4 ppm), the reference value in units of ppm was applied as a vapor with a little mist. [Evidence Data] (1) LC50 (4 hours) for rats: > 10,000 ppm (ACGIH (7th, 2001), HSDB (Access on June 2019))
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	[Rationale for the Classification] Based on (1), it was classified in Category 2. [Evidence Data] (1) This substance exhibits moderate to severe persistent irritation to the skin of rabbits (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on June 2019)).
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	[Rationale for the Classification] Based on (1), it was classified in Category 2. Besides, it was classified in Category 2A in the previous classification, but since detailed score data and the recovery period could not be confirmed, sub-categorization was not performed. [Evidence Data] (1) Administration of this substance (undiluted) to the eyes of rabbits caused severe eye irritation and edema, which resolved within a few days (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on June 2019)).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) This substance did not show sensitization reactions in a test with guinea pigs (PATTY (6th, 2012)).
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] Based on (1) and (2), since all of the standard combination tests, including in vivo and in vitro tests, were negative, it was classified as "Not classified." [Evidence Data] (1) As for in vivo, a negative result was reported for a micronucleus test with bone marrow of mice (JECDB (Access on June 2019)). (2) As for in vitro, negative results were reported for a bacterial reverse mutation test, a mouse lymphoma test and a chromosomal aberration test with cultured mammalian cells (JECDB (Access on June 2019), ACGIH (7th, 2001), PATTY (6th, 2012)).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (1) and (2), no reproductive or developmental effects were observed in the reproduction/developmental toxicity screening test, but in the developmental toxicity test, increased fetal resorption, external abnormalities and skeletal and visceral defects were observed at the dose where no maternal toxicity was observed. Therefore, it was classified in Category 1B. Besides, the classification evidence data were reviewed and the category was changed. [Evidence Data] (1) In a reproduction/developmental toxicity screening test (OECD TG 421) with rats administered by gavage, as parental toxicity, thickening of the mucosa of the forestomach and salivation were observed, but no reproductive effects were. As for effects on the offspring, agnathia, low set pinna, microphthalmia and hydronephrosis were observed in 1 dead offspring, but these were considered to be spontaneous malformations and it was determined that there was no effect on the offspring (JECDB (Access on June 2019)). (2) In a developmental toxicity test with female rats administered by gavage on gestation Days 6-15, gross abnormalities, and skeletal and soft tissue defects were observed at the dose at which maternal toxicity was not observed. In addition, an increased frequency of fetal resorption was observed (PATTY (6th, 2012), Mehlman MA, et al.; Toxicol Appl Pharmacol 72 (1): 11923).
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 3 (respiratory tract irritation). [Evidence Data] (1) It was described that it was irritating to the eyes, skin and upper respiratory system in humans (PATTY (6th, 2012), HSDB (Access on June 2019)). (2) In a single inhalation exposure test with rats, profound discomfort (the state of being restless), irritation and respiratory distress were observed (ACGIH (7th, 2001)).
9	Specific target organ toxicity - Repeated exposure	Category 2 (eye, nervous system, respiratory organs, bone, hematopoietic system)	Warning	H373	P260 P314 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 2 (eye, nervous system, respiratory organs, bone, hematopoietic system). Besides, as a result of reviewing the observed effects, the previous classification was changed. [Evidence Data] (1) In a 28-day oral administration test with rats, in addition to changes in the forestomach considered to be caused by irritation, hypertrophy of alveolar Type II cells cells was seen at or above 60 mg/kg/day (converted guidance value: 18.7 mg/kg/day, within the range of Category 2), and decreased locomotor activity, tremors, salivation, increases in red blood cell counts, hemoglobin and hematocrit, cataracts, hypertrophy of thyroid follicular epithelium, atrophy of the thymus, alveolar/perivascular infiltration of inflammatory cells and aggregation of foam cells, degeneration of nerve fibers of the sciatic nerve and spinal cord, central chromatolysis of nerve cells in the pons (brainstem) and spinal cord, closure of the epiphyseal plate of bone, decreased extramedullary hematopoiesis in the spleen, and decreased hematopoiesis in the bone marrow, etc. were observed at 250 mg/kg/day (converted guidance value: 77.8 mg/kg/day, within the range of Category 2) (JECDB (Access on June 2019)). (2) In a 4-week (6 hours/day, 5 days/week) inhalation exposure test with rats, clinical signs of eye irritation and mild reversible striate opacities of the lenses at or above 100 ppm (converted guidance value: 0.11 mg/L, within the range of Category 1), deaths (10%) and mild cataracts at or above 300 ppm (converted guidance value: 0.34 mg/L, within the range of Category 2), deaths (over 70%), and lung inflammation and severe cataracts at 600 ppm (converted guidance value: 0.68 mg/L, within the range of Category 2) were observed (ACGIH (7th, 2001), PATTY (6th, 2012)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	This substance quickly hydrolyzes in water to form dimethyl phosphite and methanol. From 48-hour EC50 = 25 mg/L for crustacea (Daphnia magna) for dimethyl phosphite (SIDS, 2004), this substance was classified in Category 3.
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	This substance quickly hydrolyzes in water to form dimethyl phosphite and methanol. Reliable chronic toxicity data were not obtained for both products. This substance was classified in Category 3 because it was classified in Category 3 in acute toxicity, and dimethyl phosphite is not rapidly degradable (a degradation rate by BOD: 48% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1997)).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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