NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	7488-55-3
Chemical Name	Tin sulphate
Substance ID	R01-B-047
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7	Flammable solids	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on July 2019)).
8	Self-reactive substances and mixtures	*	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10	Pyrophoric solids	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on July 2019)).
11	Self-heating substances and mixtures	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on July 2019)).
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	It was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility information of 18.8 g/100 mL (CRC (98th, 2017)).
13	Oxidizing liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	It is an inorganic compound containing oxygen (but not halogen). However, the classification is not possible due to no data.
15	Organic peroxides	*	- -	-	-	Inorganic compound. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." The category was changed from the previous classification by using the new information source. [Evidence Data] (1) LD50 for rats: 2,207 mg/kg (REACH registration dossier (Access on September 2019))
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	[Rationale for the Classification] From (1), it does not correspond to Category 1, and based on (2), it was classified in Category 2. Besides, the category was changed since new data were available. [Evidence Data] (1) In an in vitro skin corrosion test with human skin model according to OECD TG 431, the tissue viability after 3- and 60-minute exposure was 95% and 79%, respectively (REACH registration dossier (Access on September 2019)). (2) Inorganic tin compounds are irritating to the eyes and skin (HSDB (Access on August 2019)). [Reference Data, etc.] (3) It was classified in "Skin Irrit. 2 (H315)" in the EU CLP classification (EU CLP classification (Access on September 2019)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. Besides, the category was changed since new data were available. [Evidence Data] (1) The pH of a 2.5% solution of this substance is described to be less than 2 (REACH registration dossier (Access on September 2019)). (2) Inorganic tin compounds are irritating to the eyes and skin (HSDB (Access on August 2019)). [Reference Data, etc.] (3) It was classified in "Eye Dam. 1 (H318)" in the EU CLP classification (EU CLP classification (Access on September 2019)).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1. The category was changed since new data were available. [Evidence Data] (1) Divalent tin compounds are reported to be positive in a human patch test (REACH registration dossier (Access on September 2019)). [Reference Data, etc.] (2) It was classified in "Skin Sens. 1 (H317)" in the EU-CLP classification (EU CLP classification (Access on September 2019)).
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] Although there is no information on this substance itself, from (1), it was judged that classification based on the information on soluble stannous compounds was possible. Based on (2) and (3), it was classified as "Not classified." [Evidence Data] (1) There is a description that this substance is an inorganic tin compound, which is quite soluble in water (solubility of 188 g/L) (CRC (98th, 2017)). (2) As for in vivo tests with soluble stannous compounds, there are negative reports in micronucleus tests with mice using tin(II) chloride (CAS RN 7772-99-8) and tin(II) fluoride (CAS RN 7783-47-3) (CICAD 65 (2008)). (3) As for in vitro tests with soluble stannous compounds, there are negative reports in bacterial reverse mutation tests using tin(II) chloride (CAS RN 7772-99-8) and tin(II) fluoride (CAS RN 7783-47-3)and in a chromosomal aberration test with cultured mammalian cells using stannous chloride (CAS RN 7772-99-8) (CICAD 65 (2008)).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] Limited in nature but available experimental animal studies with tin compounds have not shown tin metal, tin (II) chloride or a small number of other tin compounds to be carcinogenic (CICAD 65 (2005)).
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) Only limited data were identified on the reproductive and developmental toxicity of inorganic tin compounds. No adverse effects were found in rats when tin was given in the diet for three generations or when some tin compounds were given in the diet throughout pregnancy. Similarly, repeated gavage treatment of pregnant rats, mice, and hamsters with tin (II) chloride was without adverse effect on the fetuses (CICAD 65 (2005)).
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 3 (respiratory tract irritation). [Evidence Data] (1) There is a description that this substance is an inorganic tin compound, which is quite soluble in water (solubility of 188 g/L) (CRC (98th, 2017)). (2) There is a description that inorganic tin compounds can irritate the nose and throat (HSDB (Access on August 2019)). (3) The pH of a 2.5% solution of this substance is described to be less than 2 (REACH registration dossier (Access on October 2019)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (lung), Category 2 (liver, blood system)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1), effects on lungs in humans may occur by inhalation exposure to metal tin and inorganic tin compounds, and based on (2), effects on the liver and blood system were observed within the range of Category 2 by oral administration to rats, therefore, it was classified in Category 1 (lung), category 2 (liver, blood system). [Evidence Data] (1) The ACGIH recommends Threshold Limit Values in the workplace (TLV-TWA of 2 mg/m3 as inhalable particulate matter) for elemental tin, tin oxides and tin inorganic compounds (except tin hydride and indium tin oxide) in order to prevent stannosis (ACGIH (7th, 2019)). (2) In a 4-week feeding study with rats, decreased hemoglobin and hematocrit were observed at or above 83 mg/kg/day (converted guidance value: 26 mg/kg/day, within the range of Category 2), and decreased liver weight, homogenous hepatocyte cytoplasm and bile duct hyperplasia were observed at 275 mg/kg/day (converted guidance value: 86 mg/kg/day, within the range of Category 2) (ATSDR (2005), CICAD 65 (2005), EHC 15 (1980), de Groot et al. (1973)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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