GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 814-94-8
Chemical Name Tin(II) oxalate
Substance ID R01-B-048
Classification year (FY) FY2019
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2 Flammable gases *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3 Aerosols *
-
-
- - Not aerosol products. It was classified as "Not classified (Not applicable)."
4 Oxidizing gases *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5 Gases under pressure *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6 Flammable liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7 Flammable solids *
-
-
- - No data available.
8 Self-reactive substances and mixtures *
-
-
- - There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)."
9 Pyrophoric liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10 Pyrophoric solids *
-
-
- - It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 501 deg C (REACH registration dossier (Access on August 2019)).
11 Self-heating substances and mixtures *
-
-
- - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases *
-
-
- - It was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility information of 5.97 mg/L (REACH registration dossier (Access on August 2019)).
13 Oxidizing liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14 Oxidizing solids *
-
-
- - It is an inorganic compound containing oxygen (but not halogen). However, the classification is not possible due to no data.
15 Organic peroxides *
-
-
- - It is an inorganic compound (CRC (98th, 2017)). It was classified as "Not classified (Not applicable)."
16 Corrosive to metals *
-
-
- - Classification is not possible because test methods applicable to solid substances are not available.
17 Desensitized explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) LD50 for rats: > 2,000 mg/kg (REACH registration dossier (Access on September 2019))
1 Acute toxicity (Dermal) *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) LD50 for rabbits: > 2,000 mg/kg (REACH registration dossier (Access on September 2019))
1 Acute toxicity (Inhalation: Gases) *
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1 Acute toxicity (Inhalation: Vapours) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4


Warning
H332 P304+P340
P261
P271
P312
[Rationale for the Classification]
Based on (1), it was classified in Category 4.
The category was changed from the previous classification by using new information source.

[Evidence Data]
(1) LC50 (aerosol, 4 hours) for rats: 2 mg/L (REACH registration dossier (Access on September 2019))
2 Skin corrosion/irritation *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) In a skin irritation test with rabbits conducted according to OECD TG 404, no skin reaction was observed and the mean scores at 24/48/72 hours were all 0 (REACH registration dossier (Access on September 2019)).

[Reference Data, etc.]
(2) In an in vitro skin corrosion test using human skin model conducted according to OECD TG 431, the tissue viability after 3-minute and 60-minute exposure was 41% and 0%, respectively, and it was judged to be corrosive (REACH registration dossier (Access on September 2019)).
3 Serious eye damage/eye irritation *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified." The category was changed since new data were obtained.

[Evidence Data]
(1) In an eye irritation test with rabbits conducted according to OECD TG 405, irritation scores at 24/48/72 hours were all 0 (REACH registration dossier (Access on September 2019)).

[Reference Data, etc.]
(2) It was classified in "Eye Dam. 1 (H318)" in the EU-CLP classification (EU CLP classification (Access on September 2019)).
4 Respiratory sensitization *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
[Rationale for the Classification]
Based on (1), it was classified in Category 1. The category was changed since new data were obtained.

[Evidence Data]
(1) Divalent tin compounds are reported to be positive in a human patch test (REACH registration dossier (Access on September 2019)).

[Reference Data, etc.]
(2) This substance was predicted to not be sensitising to guinea pigs by QSAR (REACH registration dossier (Access on September 2019)).
5 Germ cell mutagenicity *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
6 Carcinogenicity *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
(1) Limited in nature but available experimental animal studies with tin compounds have not shown tin metal, tin (II) chloride or a small number of other tin compounds to be carcinogenic (CICAD 65 (2005)).
7 Reproductive toxicity *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
(1) Only limited data were identified on the potential of inorganic tin compounds to cause reproductive and developmental toxicity. No adverse effects were found in rats when tin was given in the diet for three generations or when tin compounds were given in the diet throughout pregnancy. Similarly, repeated gavage treatment of pregnant rats, mice, and hamsters with tin (II) chloride was without adverse effect on the fetuses (CICAD 65 (2005)).
8 Specific target organ toxicity - Single exposure *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data. It was impossible to confirm the description in ACGIH-TLV (2006) that inorganic tin compounds are irritating to the respiratory tract, which is evidence of respiratory tract irritation in the previous classification. Therefore, the classification result was changed.
9 Specific target organ toxicity - Repeated exposure Category 1 (lung), Category 2 (liver, blood system)


Danger
Warning
H372
H373
P260
P264
P270
P314
P501
[Rationale for the Classification]
Based on (1) and (2), effects on human lungs may occur by inhalation exposure to metallic tin and inorganic tin compounds, and based on (3), effects on the liver and blood system were observed within the range of Category 2 by oral administration to rats, therefore, it was classified in Category 1 (lung), Category 2 (liver, blood system).

[Evidence Data]
(1) Inhalation exposure to the dust and fume of tin (oxide) is recognized to result in stannosis (mild pneumoconiosis) (ACGIH (7th, 2019)).
(2) The ACGIH recommends Threshold Limit Values in the workplace (TLV-TWA of 2 mg/m3 as inhalable particulate matter) for elemental tin, tin oxides and tin inorganic compounds (excluding tin hydride and indium tin oxide) in order to prevent stannosis (ACGIH (7th, 2019)).
(3) In a 4-week feeding study with rats, decreased hemoglobin and hematocrit, bile duct hyperplasia and homogenous hepatocyte cytoplasm were observed at or above 86 mg/kg/day (converted guidance value: 27 mg/kg/day, within the range of Category 2) (ATSDR (2005), CICAD 65 (2005), EHC 15 (1980), de Groot et al. (1973)).
10 Aspiration hazard *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) Classification not possible
-
-
- - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment Long term (Chronic) Classification not possible
-
-
- - Classification not possible due to lack of data.
12 Hazardous to the ozone layer Classification not possible
-
-
- - Classification not possible due to lack of data.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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