NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	10035-10-6
Chemical Name	Hydrobromic acid
Substance ID	R01-B-060
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (Hommel (1991)).
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	It was classified as "Not classified" because it is classified in Division 2.3, Subsidiary Risk 8 in UNRTDG (UN1048), not Subsidiary Risk 5.1.
5	Gases under pressure	Low pressure liquefied gas	Warning	-	-	It was classified as low-pressure liquefied gases from information: a critical temperature of 90 deg C (Hommel (1991)).
6	Flammable liquids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
7	Flammable solids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
8	Self-reactive substances and mixtures	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
10	Pyrophoric solids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
11	Self-heating substances and mixtures	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
13	Oxidizing liquids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to gas substances are not available.
17	Desensitized explosives	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Gases)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 3. [Evidence Data] (1) LC50 (1 hour) for rats: 2,860 ppm (converted 4-hour equivalent value: 1,430 ppm) (PATTY (6th, 2012), HSDB (Access on July 2019), ACGIH (7th, 2004), DFGOT vol.13 (1999))
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1. [Evidence Data] (1) Contact of solutions of this substance with the eyes, skin, or mucous membranes may cause burns (ACGIH (7th, 2004)). (2) This substance and its aqueous solution are caustic to the eyes, skin and mucous membranes (DFGOT vol.13 (1999)). (3) The vapors of this substance are severely irritating and corrosive to the skin (DFGOT vol.13 (1999)). [Reference Data, etc.] (4) Dermatitis caused by contact with this substance is due to its strong acidity (PATTY (6th, 2012)). (5) This substance was corrosive to the skin of rats (REACH registration dossier, Access on September 2019). (6) It was classified as "Skin Corr. 1A (H314)" in the EU CLP classification (EU CLP classification (Access on July 2019)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1. [Evidence Data] (1) Contact of solutions of this substance with the eyes, skin, or mucous membranes may cause burns (ACGIH (7th, 2004)). (2) This substance and its aqueous solution are caustic to the eyes, skin and mucous membranes (DFGOT vol.13 (1999)). (3) The vapor of this substance are severely irritating to the mucous membranes of the eyes, nose and respiratory tract (DFGOT vol.13 (1999)). (4) It was classified in Skin corrosion (Category 1).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Though there is a description in (1), classification was not possible since details could not be confirmed. [Reference Data, etc.] (1) Allergic dermatitis due to this substance was reported (PATTY (6th, 2012)).
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (respiratory organs). [Evidence Data] (1) In humans, there is a report that inhalation exposure to this substance may lead to severe irritation in the upper respiratory tract, throat spasms and lung edema. Additionally, there is a report that edema of the glottis, bronchospasm, bronchopneumonia and acute lung edema may occur (DFGOT vol.13 (1999)). (2) In a single nasal inhalation exposure test with rats, by exposure for 30 minutes at 1,300 ppm (converted 4-hour equivalent value: 460 ppm, equivalent to Category 1), severe necrohemorrhagic rhinitis, showing the findings of necrosis extending from the nose mucosa to the submucosa and turbinate, blood vessel thrombosis and hemorrhage were observed. The presence of fibrin was also observed in the nasal discharge (ACGIH (7th, 2004)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, teeth)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1 (respiratory organs, teeth). [Evidence Data] (1) In workers exposed to hydrobromic acid (CAS RN 10035-10-6), an aqueous solution of this substance, chronic upper and lower airway disorders (including anosmia, aphonia with nonspecific bronchial hyperreactivity), cough, shortness of breath, and progressive bronchiolitis obliterans were reported (PATTY (6th, 2012)). (2) After long term exposure to this substance (no further details), irritation of the respiratory passages, digestive problems, slight changes in reflexes (no further details), effects on the sense of smell and a decrease in the erythrocyte count were reported (DFGOT vol.13 (1999)). (3) After long term exposure to the vapour of this substance (no further details), decalcification of the teeth and changes in the gums were reported (DFGOT vol.13 (1999)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information