Item | Information |
---|---|
CAS RN | 543-80-6 |
Chemical Name | Barium acetate |
Substance ID | R01-B-064 |
Classification year (FY) | FY2019 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)." |
2 | Flammable gases | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
3 | Aerosols | * |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." |
4 | Oxidizing gases | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
5 | Gases under pressure | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
6 | Flammable liquids | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
7 | Flammable solids | * |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (ICSC (2001)). |
8 | Self-reactive substances and mixtures | * |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)." |
9 | Pyrophoric liquids | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
10 | Pyrophoric solids | * |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (ICSC (2001)). |
11 | Self-heating substances and mixtures | * |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (ICSC (2001)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | * |
- |
- | - | It was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility data of 59 g/100 mL (20 deg C, ICSC (2001)). |
13 | Oxidizing liquids | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
14 | Oxidizing solids | * |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to an element (Ba) other than carbon or hydrogen. However, the classification is not possible due to no data. |
15 | Organic peroxides | * |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)." |
16 | Corrosive to metals | * |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. |
17 | Desensitized explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 4. [Evidence Data] (1) LD50 for rats: 300-2,000 mg/kg (REACH registration dossier (Access on October 2019)) |
1 | Acute toxicity (Dermal) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | * |
- |
- | - |
[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
1 | Acute toxicity (Inhalation: Vapours) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | * |
- |
- | - |
[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) In an in vitro skin irritation test with a human skin model compliant with OECD TG 439, the tissue viability after 60 minutes was 107.5%, therefore, it was judged as "Not classified" (REACH registration dossier (Access on October 2019)). |
3 | Serious eye damage/eye irritation | * |
- |
- | - |
[Rationale for the Classification] Although data in (1) was available, classification was not possible due to lack of data. [Reference Data, etc.] (1) In an in vitro eye damage testing (BCOP) with bovine cornea according to OECD TG 437, the mean irritation score (IVIS) was 28.49, therefore, Category 1 was denied, but no further classifications could be made (REACH registration dossier (Access on October 2019)). |
4 | Respiratory sensitization | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | * |
- |
- | - |
[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) In a local lymph node assay (LLNA) with mice according to OECD TG 429, all SI values were less than 3, and it was judged as negative (REACH registration dossier (Access on October 2019)). |
5 | Germ cell mutagenicity | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
6 | Carcinogenicity | * |
- |
- | - |
[Rationale for the Classification] Based on classification results by other organizations in (1), it was classified as "Classification not possible" in accordance with the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) As for classification results by domestic and international organizations, ACGIH classified barium and soluble compounds in A4 (ACGIH (7th, 2001)). |
7 | Reproductive toxicity | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, cardiovascular system, muscular system, kidney, gastrointestinal tract), Category 3 (respiratory tract irritation) |
Danger Warning |
H370
H335 |
P308+P311
P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
[Rationale for the Classification] There are no reports on a single exposure in humans and experimental animals to this substance. However, it is considered that information on other soluble barium compounds can be used as a reference since this substance is soluble in water from (1). Therefore, based on (2) and (3), it was classified in Category 1 (nervous system, cardiovascular system, muscular system, kidney, gastrointestinal tract), Category 3 (respiratory tract irritation). The classification result was changed from the previous classification by the use of new information sources. [Evidence Data] (1) There is a data that this substance has a water solubility of 59 g/100 mL (at 20 deg C, ICSC (2001)). Therefore, it is considered soluble in water. (2) In humans, there are descriptions that accidental or intentional ingestion of soluble barium compounds causes gastrointestinal distress (vomiting, diarrhoea, abdominal pain, etc.) and hypokalemia which can result in effects on the cardiovascular system (cardiac arrhythmias, increased or decreased blood pressure, etc.), effects on the nervous system (skeletal muscle paralysis, etc.) and the kidneys (renal failure, etc.) (ATSDR (2007), ACGIH (7th, 2001), CICAD 33 (2001)). (3) Soluble barium compounds may cause local irritation of the eyes, nose, throat, bronchial tubes, and skin (HSDB (Access on October 2019)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (cardiovascular system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1) and (2), since soluble compounds, including this substance, may cause effects on the cardiovascular system due to hypokalemia in humans, it was classified in Category 1 (cardiovascular system). Besides, new information sources were used to review and the classification result was changed from the previous classification. [Evidence Data] (1) There is a report that increases in the prevalence of hypertension, heart disease, or stroke were found in the human population in a residential area where drinking water containing soluble barium such as barium chloride had been consumed. In addition, increased mortality due to cardiovascular disease and heart disease (arteriosclerosis) in another similar community was observed (ATSDR (2007)). (2) Increased incidence of hypertension among workers exposed to soluble barium at average level of 1.07 mg/m3 by mixing and grinding various grades of barium at a mineral processing facility is reported (CICAD 33 (2001)). [Reference Data, etc.] (3) The barium ion is a chemical antagonist of potassium, and barium induces hypokalemia by promoting a transfer of potassium from extracellular to intracellular compartments (ACGIH (7th, 2001)). (4) In studies in which barium chloride (CAS RN 10361-37-2) or barium chloride dihydrate (CAS RN 10326-27-9) was administered by drinking water to rats or mice for 13 weeks or 2 years, effects on the kidney (death from nephropathy, tubule dilatation) were observed at doses exceeding Category 2 in all studies, and kidney is described to be the most sensitive target organ in experimental animals (ATSDR (2007)). (5) Barium chloride was classified in Category 1 (cardiovascular system, nervous system, muscular system, kidney) (GHS Classification Result in FY2014). |
10 | Aspiration hazard | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
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