GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 12208-13-8
Chemical Name Potassium hexahydroxoantimonate
Substance ID R01-B-067
Classification year (FY) FY2019
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2 Flammable gases *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3 Aerosols *
-
-
- - Not aerosol products. It was classified as "Not classified (Not applicable)."
4 Oxidizing gases *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5 Gases under pressure *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6 Flammable liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7 Flammable solids *
-
-
- - It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).
8 Self-reactive substances and mixtures *
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)."
9 Pyrophoric liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10 Pyrophoric solids *
-
-
- - It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).
11 Self-heating substances and mixtures *
-
-
- - It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).
12 Substances and mixtures which, in contact with water, emit flammable gases *
-
-
- - It was classified as "Not classified" because it is estimated that it does not react vigorously with water from information: water solubility of 28 g/L (20 deg C, GESTIS (Access on September 2019)).
13 Oxidizing liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14 Oxidizing solids *
-
-
- - It is an inorganic compound containing oxygen (but not halogen). However, the classification is not possible due to no data.
15 Organic peroxides *
-
-
- - Inorganic compound. It was classified as "Not classified (Not applicable)."
16 Corrosive to metals *
-
-
- - Classification is not possible because test methods applicable to solid substances are not available.
17 Desensitized explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Dermal) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) *
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1 Acute toxicity (Inhalation: Vapours) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) LC50 value for rats (4 hours, dust): > 5.4 mg/L (REACH registration dossier (Access on November 2019))
2 Skin corrosion/irritation *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) In a skin irritation test with rabbits in accordance with OECD TG 404, every mean score at 24/48/72 hours was 0 (REACH registration dossier (Access on October 2019)).
3 Serious eye damage/eye irritation *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) In an eye irritation test with rabbits in accordance with OECD TG 405, every mean score of conjunctival redness, chemosis, cornea opacity or iris at 24/48/72 hours was 0 (REACH registration dossier (Access on October 2019)).
4 Respiratory sensitization *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) In a mouse local lymph node assay (LLNA) in accordance with OECD TG 429, SI values were less than 3, therefore, it was judged as negative (REACH registration dossier (Access on October 2019)).
5 Germ cell mutagenicity *
-
-
- - [Rationale for the Classification]
There are no in vivo data. Therefore, classification was not possible due to lack of data.

[Evidence Data]
(1) As for in vitro, there is a report that it was negative in a bacterial reverse mutation test (DFGOT vol.23 (2007)).
6 Carcinogenicity *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data. The category was changed by reviewing classification results by other organizations.

[Reference Data, etc.]
(1) As for classification results by domestic and international organizations for antimony compounds, IARC classified antimony trioxide (CAS RN 1309-64-4) in Group 2B and antimony trisulfide (CAS RN 1345-04-6) in Group 3.
7 Reproductive toxicity *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
(1)In a developmental toxicity test by gavage administration of the sodium salt (sodium hexahydroxoantimonate, CAS RN 33908-66-6) with female rats during day 6 to 19 of pregnancy, at the highest dose (1,000 mg/kg), neither maternal nor developmental toxicity was observed (REACH registration dossier (Access on October 2019)).
8 Specific target organ toxicity - Single exposure Category 1 (lung, cardiovascular system)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
[Rationale for the Classification]
From (1) and (2), there is a risk that acute exposure affects the lung and cardiovascular system in humans, therefore, it was classified in Category 1 (lung, cardiovascular system).

[Evidence Data]
(1) There is no information on this substance itself, however, as for antimony and its compounds, there is a description that pneumonitis and cardiac and hematological disorders would be anticipated by exposures at high concentrations, acute or chronic (ACGIH (7th, 2001)).
(2) In "Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labuor and Welfare" (Ministry of Labour Notification No. 33, 1996), the diseases designated by the Minister of Labour (currently the Minister of Health, Labour and Welfare) for antimony and its compounds are described as headache, dizziness, vomiting and other subjective symptoms, skin disorders, ocular disorders, myocardial disorders or gastrointestinal disorders.

[Reference Data, etc.]
(3) As for sodium salt (sodium hexahydroxoantimonate, CAS RN 33908-66-6), there is a report that in a 4-hour dust inhalation test with rats at 5.4 mg/L (corresponding to Category 2), there were no deaths, signs of respiratory irritation, or test substance-related histopathological changes in the nose, larynx, trachea and lung (REACH registration dossier (Access on October 2019)).
9 Specific target organ toxicity - Repeated exposure Category 1 (lung, cardiovascular system)


Danger
H372 P260
P264
P270
P314
P501
[Rationale for the Classification]
From (1) and (2), there is a risk that repeated exposure affects the lung and cardiovascular system in humans, therefore, it was classified in Category 1 (lung, cardiovascular system).

[Evidence Data]
(1) There is no information on this substance itself, however, as for antimony and its compounds, there is a description that pneumonitis and cardiac and hematological disorders would be anticipated by exposures at high concentrations, acute or chronic (ACGIH (7th, 2001)).
(2) In "Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labuor and Welfare" (Ministry of Labour Notification No. 33, 1996), the diseases designated by the Minister of Labour (currently the Minister of Health, Labour and Welfare) for antimony and its compounds are described as headache, dizziness, vomiting and other subjective symptoms, skin disorders, ocular disorders, myocardial disorders or gastrointestinal disorders.

[Reference Data, etc.]
(3) Oral administration of sodium hexahydroxoantimonate (CAS RN 33908-66-6) to rats for 90 days resulted in no dose-related effects observed at up to 1,000 mg/kg/day (exceeding the range of Category 2) (REACH registration dossier (Access on October 2019)).
10 Aspiration hazard *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) Category 3
-
-
H402 P273
P501
It was classified in Category 3 from 96-hour LC50 = 6.9 mg Sb/L (14.9 mg this substance/L) for fish (Pagrus major) (Environmental Risk Assessment for Chemical Substances Vol. 15 (Ministry of the Environment, 2017)).
11 Hazardous to the aquatic environment Long term (Chronic) Category 2


-
H411 P273
P391
P501
If chronic toxicity data are used, then it is classified as "Not classified" due to 21-day NOEC = 29.3 mg Sb/L (63.3 mg this substance/L) for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances Vol. 15 (Ministry of the Environment, 2017)), despite unknown environmental dynamics of the inorganic compound.
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to 96-hour LC50 = 6.9 mg Sb/L (14.9 mg this substance/L) for fish (Pagrus major) (Environmental Risk Assessment for Chemical Substances Vol. 15 (Ministry of the Environment, 2017)), despite unknown environmental dynamics of the inorganic compound.
By drawing a comparison between the above results, it was classified in Category 3.
12 Hazardous to the ozone layer Classification not possible
-
-
- - Classification not possible due to lack of data.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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