NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	1314-34-7
Chemical Name	Vanadium(III) oxide
Substance ID	R01-B-070
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2010
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7	Flammable solids	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).
8	Self-reactive substances and mixtures	*	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10	Pyrophoric solids	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).
11	Self-heating substances and mixtures	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	It contains a metal (V), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from information: water solubility of 0.01 g/100 mL (20 deg C) (very poor) (ICSC (J) (2006)).
13	Oxidizing liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.
15	Organic peroxides	*	- -	-	-	Inorganic compound. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." Besides, the GLP test results were adopted by putting a higher priority on reliability. [Evidence Data] (1) LD50 for rats: > 2,000 mg/kg (REACH registration dossier (Access on September 2019), HSDB (Access on August 2019)) [Reference Data, etc.] (2) LD50 for rats: 566 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013))
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." The GLP test results were adopted by putting a higher priority on reliability. [Evidence Data] (1) LD50 for rats: > 2,500 mg/kg (REACH registration dossier (Access on September 2019)) [Reference Data, etc.] (2) LD50 for rabbits: 200 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013))
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." The category was changed from the previous classification by the use of the new information sources. [Evidence Data] (1) LC50 (4 hours) for rats: > 6.65 mg/L (HSDB (Access on August 2019), REACH registration dossier (Access on September 2019))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	[Rationale for the Classification] Based on (1), it was classified in Category 2. [Evidence Data] (1) In "Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare" (Ministry of Labor Notification No. 33, 1996), the diseases designated by the Minister of Labour (currently the Minister of Health, Labour and Welfare) for vanadium and its compounds are described as skin disorders, anterior eye disorders or respiratory tract/pulmonary disorders. [Reference Data, etc.] (2) In an in vitro skin irritation test according to OECD draft TG (EPISKIN Standard Model), the cell viability (relative absorbance value) after 15-minute exposure was 86.2%, and it was classified as "Not classified" in the GHS classification (REACH registration dossier (Access on October 2019)).
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 2A. Since new data were obtained, the category was changed. [Evidence Data] (1) In an eye irritation test with rabbits according to OECD TG 405, the mean scores of 24/48/72 hours were <1 for corneal opacity, 0 for the iris, 2 for conjunctival redness and <2 for conjunctival edema, respectively, and all were fully reversible by 21 days (REACH registration dossier (Access on October 2019)). (2) Exposure to this substance in the form of dust or fume may result in irritation in the eyes and mucous membranes (DFGOT vol.25 (2009), HSDB (Access on August 2019)). (3) In "Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare" (Ministry of Labor Notification No. 33, 1996), the diseases designated by the Minister of Labour (currently the Minister of Health, Labour and Welfare) for vanadium and its compounds are described as skin disorders, anterior eye disorders or respiratory tract/pulmonary disorders.
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) The literature available on vanadium compounds does not demonstrate sensitization of the skin or the respiratory passages unambiguously (DFGOT vol.25 (2009)). (2) Inhalation of this substance and vanadium pentoxide for 1-5 years produced asthma in 3 of 20 workers (HSDB (Access on September 2019)).
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) In a guinea-pig skin sensitization test according to OECD TG 406 (Maximization, intradermal induction: 0.01%, induction (topical application): 50%, challenge: 25%), no skin reactions were observed and the sensitization potential was concluded to be negative (REACH registration dossier (Access on October 2019)). [Reference Data, etc.] (2) The literature available on vanadium compounds does not demonstrate sensitization of the skin or the respiratory passages unambiguously (DFGOT vol.25 (2009)).
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] There are no data for in vivo test. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, it is reported in tests with cultured mammalian cells that it was positive in a chromosomal aberration test (DFGOT vol.25 (2009)), negative in a gene mutation test, and positive in a sister chromatid exchange test (SCE) (HSDB (Access on August 2019)).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1 (respiratory organs). The classification was changed from the previous classification by a review of the information. [Evidence Data] (1) It is described that acute exposure to vanadium oxide dust is associated with upper and lower airway irritation, and that rhinitis and pharyngitis commonly occur within 0.5 hours of exposure and up to 12 hours after the exposure, and that coughing, wheezing, dyspnea, and substernal soreness occur with more severe exposures (HSDB (Access on August 2019)). (2) There is a description that vanadium compounds act chiefly as an irritant to the conjunctiva and respiratory tract (HSDB (Access on August 2019)). (3) In "Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare" (Ministry of Labor Notification No. 33, 1996), the diseases designated by the Minister of Labour (currently the Minister of Health, Labour and Welfare) for vanadium and its compounds are described as skin disorders, anterior eye disorders or respiratory tract/pulmonary disorders.
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1 (respiratory organs). [Evidence Data] (1) The chronic form of the occupational disease results from repeated inhalation of dusts containing vanadium over a prolonged period of time. Bronchitis develops from irritation of the upper respiratory tract which may turn into a chronic form. In particularly severe cases, bronchopneumonia with fever and obstructive diseases of the airways with conditions similar to those of bronchial asthma are observed (DFGOT vol.25 (2009)). (2) Respiratory symptoms, such as nasal discharge, sneezing, dyspnea, and asthmatic reactions, were seen in rabbits exposed to the aerosol of this substance at 40-75 mg/m3, for 2 hours/day over 9-12 months (converted guidance value: 0.01-0.02 mg/L, within the range of Category 1) (EHC 81 (1988)). (3) In "Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare" (Ministry of Labor Notification No. 33, 1996), the diseases designated by the Minister of Labour (currently the Minister of Health, Labour and Welfare) for vanadium and its compounds are described as skin disorders, anterior eye disorders or respiratory tract/pulmonary disorders.
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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