GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 12656-85-8
Chemical Name Lead chromate molybdate sulfate
Substance ID R01-B-071
Classification year (FY) FY2019
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2 Flammable gases *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3 Aerosols *
-
-
- - Not aerosol products. It was classified as "Not classified (Not applicable)."
4 Oxidizing gases *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5 Gases under pressure *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6 Flammable liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7 Flammable solids *
-
-
- - It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).
8 Self-reactive substances and mixtures *
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)."
9 Pyrophoric liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10 Pyrophoric solids *
-
-
- - It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).
11 Self-heating substances and mixtures *
-
-
- - It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on September 2019)).
12 Substances and mixtures which, in contact with water, emit flammable gases *
-
-
- - It contains metals (Mo, Pb, and Cr), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility data of < 0.01 mg/L (20 deg C) (HSDB (Access on August 2019)).
13 Oxidizing liquids *
-
-
- - Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14 Oxidizing solids *
-
-
- - It is an inorganic compound containing oxygen (but not halogen). However, the classification is not possible due to no data.
15 Organic peroxides *
-
-
- - Inorganic compound. It was classified as "Not classified (Not applicable)."
16 Corrosive to metals *
-
-
- - Classification is not possible because test methods applicable to solid substances are not available.
17 Desensitized explosives *
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) *
-
-
- - [Rationale for the Classification]
Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) LD50 for rats: >5,000 mg/kg (Environ Health Canada (2008), HSDB (Access on August 2019))
1 Acute toxicity (Dermal) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) *
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1 Acute toxicity (Inhalation: Vapours) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
2 Skin corrosion/irritation *
-
-
- - [Rationale for the Classification]
Based on (1) and (2), it was classified as "Not classified."

[Evidence Data]
(1) No irritation was observed in skin and eye irritation tests with rabbits in compliance with OECD TG 404 and OECD TG 405, respectively (GESTIS (Access on August 2019)).
(2) No irritation was observed in a skin irritation test (no guideline followed) with rabbits (REACH registration dossier (Access on October 2019)).

[Reference Data, etc.]
(3) Chronic ulcers of the skin and irritative dermatitis were reported in workers who were continuously exposed to chromium-containing materials (IARC 49 (1990)).
3 Serious eye damage/eye irritation *
-
-
- - [Rationale for the Classification]
Based on (1) and (2), it was classified as "Not classified."

[Evidence Data]
(1) No irritation was observed in skin and eye irritation tests with rabbits in compliance with OECD TG 404 and OECD TG 405, respectively (GESTIS (Access on August 2019)).
(2) No irritation was observed in an eye irritation test (no guideline followed) with rabbits (REACH registration dossier (Access on October 2019)).
4 Respiratory sensitization Category 1A


Danger
H334 P304+P340
P342+P311
P261
P284
P501
[Rationale for the Classification]
Based on (1), it was classified in Category 1A.

[Evidence Data]
(1) Chromium and chromium compounds were designated as occupational sensitizers to the airway Group 2 by the Japan Society For Occupational Health (OEL Documentations (Occupational Sensitizer classification) (Japan Society For Occupational Health (JSOH), 2010)).
4 Skin sensitization Category 1A


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1A.

[Evidence Data]
(1) Chromium and chromium compounds were designated as occupational skin sensitizers Group 1 by the Japan Society For Occupational Health (OEL Documentations (Occupational Sensitizer classification) (Japan Society For Occupational Health (JSOH), 2010)).
(2) It was described that chromium compounds were classified as skin sensitizers in the European Union Risk Assessment Report (RAR) (REACH registration dossier (Access on October 2019)).
5 Germ cell mutagenicity Category 2


Warning
H341 P308+P313
P201
P202
P280
P405
P501
[Rationale for the Classification]
From (1)-(4), based on expert judgment, it was classified in Category 2. By using the new information sources, the classification result was changed from the previous classification.


[Evidence Data]
(1) This substance is a solid mixed phase crystal that consists of lead chromate (VI) (CAS RN 7758-97-6), lead (II) sulfate (CAS RN 7446-14-2) and lead (II) molybdate (CAS RN 10190-55-3) in proportions of 69-80%, 9-15%, and 3-7%, respectively (ECHA SVHC Support Document (2009), Environment Health Canada (2008)).
(2) As for in vivo, although this substance showed a negative result in a (micronucleus) test with mouse bone marrow cells, the authors speculated that the result may not be definitive as there was no evidence that the test material was reaching the bone marrow (Environment Health Canada (2008)).
(3) As for in vitro, positive and negative results in bacterial reverse mutation tests and positive results in a sister chromatid exchange test and a chromosomal aberration test with cultured mammalian cells were obtained for this substance (Environment Health Canada (2008)).
(4) Lead chromate (CAS RN 7758-97-6), a major component of this substance, was classified in Category 2 in the Japanese GHS classification (GHS classification in FY2014: As for in vivo, there was a positive result in a micronucleus test with mice (IARC 49 (1990)). As for in vitro, there were positive results in a bacterial reverse mutation test, and chromosomal aberration tests and sister chromatid exchange tests with cultured human lymphocytes and/or cultured mammalian cells (NICNAS (2007), CICAD 78 (2013), IARC 49 (1990)). Based on the above findings and the fact that this substance is Cr (VI) that is poorly soluble in water, it was classified in Category 2).
6 Carcinogenicity Category 1A


Danger
H350 P308+P313
P201
P202
P280
P405
P501
[Rationale for the Classification]
Based on classification results by other organizations as a hexavalent chromium compound in (1), it was classified in Category 1A in accordance with the GHS Classification Guidance for the Japanese Government.

[Evidence Data]
(1) As for classification results by domestic and international organizations, it was classified in Group 1 as chromium (VI) compounds by IARC (IARC 100 C (2012)), as K as chromium hexavalent compounds (CAS RN 18540-29-9) by NTP (NTP 14th RoC (2016)), in Group 1 as chromium (VI) compounds (CAS RN 18540-29-9) by the Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (FY2019)) and in Carc. 1B in the EU CLP (EU CLP classification (Access on August 2019)).
7 Reproductive toxicity Category 1A


Danger
H360 P308+P313
P201
P202
P280
P405
P501
[Rationale for the Classification]
There are no data on this substance. However, this substance is a mixture containing lead compounds based on (1). In addition, based on (2), it was classified in Category 1A.

[Evidence Data]
(1) This substance is a solid mixed phase crystal that consists of lead chromate (VI) (CAS RN 7758-97-6), lead (II) sulfate (CAS RN 7446-14-2), and lead (II) molybdate (CAS RN 10190-55-3) in proportions of 69-80%, 9-15% and 3-7%, respectively (ECHA SVHC Support Document (2009), Environment Health Canada (2008)).
(2) The Japan Society For Occupational Health (JSOH) classified lead and lead compounds as reproductive toxicants Group 1 (corresponding to Category 1A) (OEL Documentations (Reproductive toxicant classification) (Japan Society For Occupational Health (JSOH), 2013)).

[Reference Data, etc.]
(3) It was classified in Repr. 1A in the EU CLP classification.
(4) Lead chromate(VI) (CAS RN 7758-97-6) was classified in Category 1A in the Japanese GHS classification (please refer to the GHS classification in FY2014).
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, respiratory organs, cardiovascular system, blood system, liver, kidney)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
[Rationale for the Classification]
There are no reports on single exposure to this substance in humans or experimental animals. However, based on (1) and (2), toxicity information on lead and hexavalent chromium compounds may be helpful. Therefore, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, blood system, liver, kidney) based on (3) and (4).

[Evidence Data]
(1) This substance is a solid mixed phase crystal that consists of lead chromate (VI) (CAS RN 7758-97-6), lead (II) sulfate (CAS RN 7446-14-2), and lead (II) molybdate (CAS RN 10190-55-3) in proportions of 69-80%, 9-15% and 3-7%, respectively (ECHA SVHC Support Document (2009), Environment Health Canada (2008)).
(2) Lead chromate (VI) of the highest content, is a lead compound and is also a hexavalent chromium compound. There is no information on lead chromate (VI) itself. However, based on information on lead compounds and hexavalent chromium compounds, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, blood system, liver, kidney) in the GHS classification in FY2014.
(3) In humans, symptoms of acute lead toxicity are reported to be dullness, restlessness, irritability, poor attention span, headaches, muscular tremors, hallucinations, loss of memory and renal impairment (OEL Documentations (Occupational exposure limit based on biological monitoring) (Japan Society For Occupational Health (JSOH), 2013), ATSDR (2007), EHC 3 (1977)).
(4) As acute toxic effects of hexavalent chromium compounds in humans, respiratory, cardiovascular, gastrointestinal, hematological, hepatic, renal and neurological effects are reported via the oral route (CICAD 78 (2013)). In addition, it is reported to cause respiratory tract irritation via the inhalation route (ACGIH (7th, 2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, respiratory organs, blood system, cardiovascular system, kidney)


Danger
H372 P260
P264
P270
P314
P501
[Rationale for the Classification]
Based on (1), since this substance is an inorganic lead compound consisting mainly of lead chromate, it is considered that the toxicity information on lead and hexavalent chromium compounds can be helpful. It was classified in Category 1 (central nervous system, respiratory organs, blood system, cardiovascular system, kidney) because effects on the central nervous system, blood system and kidneys were observed within the range of Category 2 by oral administration of this substance to experimental animals based on (2) and (3), effects on the nervous system, blood system, cardiovascular system and kidneys were considered as target organs for lead in humans based on (4), and it was classified in Category 1 (respiratory organs) as lead (VI) chromate based on (5).

[Evidence Data]
(1) This substance is a solid mixed phase crystal that consists of lead chromate (VI) (CAS RN 7758-97-6), lead (II) sulfate (CAS RN 7446-14-2), and lead (II) molybdate (CAS RN 10190-55-3) in proportions of 69-80%, 9-15%, and 3-7%, respectively (ECHA SVHC Support Document (2009), Environment Health Canada (2008)).
(2) As a result of oral administration of this substance to dogs for 90 days at 2,000 ppm (60 mg/kg/day, within the range of Category 2), decreases in hemoglobin and hematocrit values, altered erythrocyte morphology, increased aminolevulinic acid in the urine, as well as pathological changes of the kidneys were observed. In addition, as clinical findings prior to death, impaired gonadal development, lethargy, anorexia, dehydration, emaciation, hyperirritability, disorientation, motor ataxia and convulsions, etc. were observed (Environment Canada/Health Canada (2008)).
(3) As a result of oral administration of this substance to rats for 90 days, at 2,000 ppm (100 mg/kg/day, within the range of Category 2), similar findings as in dogs, such as hematological, urinary and renal effects, were observed (Environment Canada/Health Canada (2008)).
(4) Studies on workers, and adults and children of the general population showed that the most sensitive end points for lead toxicity are the developing nervous system, the blood system (inhibition of heme synthesis, etc.), the cardiovascular system (increased blood pressure, etc.) and the kidney (depressed glomerular filtration rate, etc.) (ATSDR (2007)).
(5) There is no information on lead chromate (VI), itself, but based on information on lead compounds and hexavalent chromium compounds, it was classified in Category 1 (respiratory organs) in the GHS classification in FY2014.
10 Aspiration hazard *
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) Classification not possible
-
-
- - Classification not possible due to lack of data.
11 Hazardous to the aquatic environment Long term (Chronic) Category 4
-
-
H413 P273
P501
Acute toxicity was not reported at up to a concentration of water solubility, but because it is a metal compound, and its behavior in water is unknown, it was classified in Category 4.
12 Hazardous to the ozone layer Classification not possible
-
-
- - Classification not possible due to lack of data.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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