NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	75-63-8
Chemical Name	Bromo(trifluoro)methane
Substance ID	R01-B-093
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (Hommel (1991)). Besides, it is classified in Division 2.2 in UNRTDG (UN1009).
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	It was classified as "Not classified" because it is classified in Division 2.2 in UNRTDG (UN1009), and Division 5.1 is not assigned, including Subsidiary Risk.
5	Gases under pressure	Low pressure liquefied gas	Warning	-	-	It was classified as low-pressure liquefied gases from a critical temperature of 66.8 deg C (GESTIS (Access on Sep. 2019)).
6	Flammable liquids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
7	Flammable solids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
8	Self-reactive substances and mixtures	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
10	Pyrophoric solids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
11	Self-heating substances and mixtures	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
13	Oxidizing liquids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to gas substances are not available.
17	Desensitized explosives	*	- -	-	-	Gas (GHS definition). It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) An inhalation exposure test with rats (6 hours): 50,000 ppm (converted 4-hour equivalent value: 61,200 ppm), no death case (DFGOT vol.6 (1993)).
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."
2	Skin corrosion/irritation	*	- -	-	-	[Rationale for the Classification] There are data in (1), but they are insufficient data for classification. Therefore, it was classified as "Classification not possible." [Reference Data, etc.] (1) An irritation to the skin and eye or frostbite may be caused by contact with this substance in the liquid or released gas states (GESTIS (Access on September 2019)).
3	Serious eye damage/eye irritation	*	- -	-	-	[Rationale for the Classification] There are data in (1), but they are insufficient data for classification. Since it was impossible to confirm the details of the data in the evidence in the previous classification, it was classified as "Classification not possible." [Reference Data, etc.] (1) An irritation to the skin and eye or frostbite may be caused by contact with this substance in the liquid or released gas states (GESTIS (Access on September 2019)).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] There are no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, there were reports of being negative in reverse mutation tests (DFGOT vol.6 (1993)).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Although it is considered that there are no developmental effects based on (1), there are no data on effects on the sexual functions and fertility of parent animals. Therefore, it was classified as "Classification not possible" due to lack of data. [Evidence Data] (1) In a developmental toxicity test in which female rats were exposed by inhalation at concentrations up to 50,000 ppm on Days 6-15 of gestation (6 hours/day), no effects were observed in the maternal animals and fetuses, and no teratogenicity was observed (DFGOT vol. 6 (1993)).
8	Specific target organ toxicity - Single exposure	Category 1 (cardiovascular system), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	[Rationale for the Classification] Since the central nervous system depression and effects on the heart were observed in humans in (1) and (2), and effects of central nervous system depression were found at high concentrations in experimental animals in (3) and (4), it was classified in Category 1 (cardiovascular system), Category 3 (narcotic effects). By review of the information, the classification result was changed from the previous classification. [Evidence Data] (1) In a study in which 4 volunteers were exposed by inhalation to 5% and 6 volunteers to 10% of this substance for a maximum of 20 minutes, 3 of the 4 persons in the 5% group complained of slight light-headedness and feeling of relaxation which were considered to be effects on the central nervous system, and all 6 persons in the 10% group complained of confusion, unsteadiness and giddiness. The authors therefore concluded that these were the first signs of narcotic effects. In the results from the electrocardiograms, a lowering or flattening of the T-wave was observed in three persons, one of whom showed bigeminy and atrioventricular dissociation (DFGOT vol.6 (1993)). (2) In a test in which volunteers were exposed by inhalation to 10% and 15% of this substance, a feeling of impending unconsciousness, paresthesia, and diminished performance were observed. In addition, at the highest concentration (16.9%), auriculoventricular dissociation and premature ventricular contractions were recorded (ACGIH (7th, 2001)). (3) In a test in which monkeys were exposed by inhalation to 20%-25% of this substance, performance decrements in operant conditioning were observed (ACGIH (7th, 2001)). (4) In a test in which mice were exposed by inhalation to this substance at 800,000 ppm (with added oxygen of 15-20%) (converted 4-hour equivalent value: 565,700 ppm, exceeding the range of Category 2) for 2 hours, activity reduced, respiratory distress, anxiety, sleepiness, slight tremors, balance and postural disorders were observed, but there were no death cases (DFGOT vol.6 (1993)).
9	Specific target organ toxicity - Repeated exposure	*	- -	-	-	[Rationale for the Classification] Based on (1) and (2), as the results by inhalation exposure of experimental animals, no toxic effects were observed even at concentrations exceeding the guidance value for Category 2. Therefore, it was classified as "Not classified." [Evidence Data] (1) When rats and guinea pigs were exposed by inhalation to an average of 23,000 ppm (exceeding the range of Category 2) for 18 weeks, no signs of intoxication were observed (ACGIH (7th, 2001)). (2) When rats, guinea pigs, dogs and cats were exposed by inhalation at a concentration of 20% for 4 weeks (3.5 hours/day, 5 days/week) (converted guidance value: 2,590 ppm, exceeding the range of Category 2), there were no changes in blood or urine parameters, and also no histopathological changes were observed other than irritant changes in the trachea (increased mucous secretion) in dogs and guinea pigs (DFGOT vol.6 (1993)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Category 1	Warning	H420	P502	This substance is listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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