Item | Information |
---|---|
CAS RN | 126-85-2 |
Chemical Name | N,N-Bis(2-chloroethyl)methylamine-N-oxide; Nitrogen mustard N-oxide |
Substance ID | R01-B-105 |
Classification year (FY) | FY2019 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | * |
- |
- | - | There is a chemical group associated with explosive properties (N-oxides) present in the molecule, and the calculated oxygen balance is -125, higher than the criteria: -200, but the classification is not possible due to no data. |
2 | Flammable gases | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
3 | Aerosols | * |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." |
4 | Oxidizing gases | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
5 | Gases under pressure | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
6 | Flammable liquids | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
7 | Flammable solids | * |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | * |
- |
- | - | There is a chemical group associated with explosive properties (N-oxides) present in the molecule, but the classification is not possible due to no data. |
9 | Pyrophoric liquids | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
10 | Pyrophoric solids | * |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | * |
- |
- | - | No data available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | * |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)." |
13 | Oxidizing liquids | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
14 | Oxidizing solids | * |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine), and the oxygen is chemically bonded to an element (N) other than carbon or hydrogen. However, the classification is not possible due to no data. |
15 | Organic peroxides | * |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)." |
16 | Corrosive to metals | * |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. |
17 | Desensitized explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Dermal) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | * |
- |
- | - |
[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
1 | Acute toxicity (Inhalation: Vapours) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
3 | Serious eye damage/eye irritation | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Respiratory sensitization | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Category 1B |
Danger |
H340 |
P308+P313
P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1), (2), it was classified in Category 1B. [Evidence Data] (1) As for in vivo, there is a report that a dominant lethal mutation test with mice was positive (IARC 9 (1975)). (2) As for in vitro, there is a report that chromosomal aberrations were induced in cultured mammalian cells (IARC 9 (1975)). |
6 | Carcinogenicity | Category 2 |
Warning |
H351 |
P308+P313
P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 2 in accordance with the GHS Classification Guidance for the Japanese Government. [Evidence Data] (1) As for classification results by domestic and international organizations, it was classified in Group 2B by IARC (IARC Sup.7 (1987)), and in Group 2B by the Japan Society for Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (proposed in 1991)). |
7 | Reproductive toxicity | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
10 | Aspiration hazard | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
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