NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	1305-99-3
Chemical Name	Tricalcium diphosphide
Substance ID	R01-B-109
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7	Flammable solids	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (ICSC (2002)). However, there is information that in contact with water or moist air, it produces a pyrophoric and toxic gas (phosphine) (Hommel (1991), ICSC (2002)).
8	Self-reactive substances and mixtures	*	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10	Pyrophoric solids	*	- -	-	-	Because it is classified in Class 4, Subsidiary Risk 6.1, PG I in UNRTDG (UN1360), it does not correspond to pyrophoric substances, hazards of the highest precedence, and it was classified as "Not classified." However, there is information that in contact with water or moist air, it produces a pyrophoric and toxic gas (phosphine) (Hommel (1991), ICSC (2002)), and handling required for pyrophoric substances is necessary.
11	Self-heating substances and mixtures	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (ICSC (2002)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Category 1	Danger	H260	P302+P335+P334 P231+P232 P370+P378 P402+P404 P223 P280 P501	It was classified in Category 1 because it is classified in Division 4.3, Subsidiary Risk 6.1, PG I in UNRTDG (UN1360).
13	Oxidizing liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	Inorganic compound containing no oxygen or halogen atoms. It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Inorganic compound. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) This substance decomposes very rapidly in contact with water to produce calcium hydroxide (CAS RN 1305-62-0) and phosphine (synonym: hydrogen phosphide, CAS RN 7803-51-2) (CLH Report (2012)). (2) LC50 for rats (6 hours) (hydrogen phosphide): >11 ppm (>0.015 mg/L) (CLH Report (2012)) (3) LC50 for rats (1 hour) (hydrogen phosphide): 204 ppm (0.29 mg/L), 179 ppm (0.25 mg/L) (CLH Report (2012))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. The category was changed due to new data obtained. [Evidence Data] (1) There is no report of an irritation test on this substance. However, since the hydrolysate of this substance is calcium hydroxide (CAS RN 1305-62-0), and the pH of calcium hydroxide is 12-13, it should be judged as a corrosive substance (ECHA RAC Background document (2013), CLH Report (2012)). (2) This substance is irritating to the skin, eyes and respiratory organs (HSDB (Access on October 2019)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. The category was changed due to the new data obtained. [Evidence Data] (1) There is no report of an irritation test on this substance. However, since the hydrolysate of this substance is calcium hydroxide (CAS RN 1305-62-0), and the pH of calcium hydroxide is 12-13, it should be judged as a corrosive substance (ECHA RAC Background document (2013), CLH Report (2012)). (2) This substance is irritating to the skin, eyes and respiratory organs (HSDB (Access on October 2019)). (3) This substance was classified as skin corrosion/irritation (Category 1). [Reference Data, etc.] (4) It was classified as "Eye Dam. 1 (H318)" in the EU CLP classification (EU CLP classification (Access on October 2019)).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Though there is a description in (1), it was classified as "Classification not possible" due to lack of data. [Reference Data, etc.] (1) There is no report of a sensitization test on this substance. However, zinc phosphide (CAS RN 1314-84-7), a substance similar to this substance, was negative in a skin sensitization test compliant with OECD TG 406. Therefore, this substance is also considered to be negative for sensitization (ECHA RAC Background document (2013), CLH Report (2012)).
5	Germ cell mutagenicity	-	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) This substance decomposes very rapidly in contact with water to produce calcium hydroxide (CAS RN 1305-62-0) and phosphine (synonym: hydrogen phosphide, CAS RN 7803-51-2) (CLH Report (2012)). (2) Phosphine was classified as "Not classified" for germ cell mutagenicity (GHS classification project in FY2019).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] There are no data on this substance itself. However, based on (1)-(3), it was classified in Category 1 (central nervous system, respiratory organs). The classification result was changed from the previous classification by the use of the new information sources. [Evidence Data] (1) This substance hydrolyzes in contact with water, or in the gastrointestinal tract, to produce calcium hydroxide (CAS RN 1305-62-0) and phosphine (synonym: hydrogen phosphide, CAS RN 7803-51-2) (CLH Report (2012), ECHA RAC Background document (2013)). (2) There is a description that calcium hydroxide is a strong base and a caustic irritant to all exposed surfaces of the body, including the eyes and respiratory system in humans (ACGIH (7th, 2001)). (3) It is described that the main target organs of phosphine are the respiratory system (cough, sore throat, dyspnea, pulmonary edema, etc.) and the central nervous system (headache, vertigo, tremors, unsteady gait, convulsions, coma, etc.) (IPCS, PIM 865 (1997)).
9	Specific target organ toxicity - Repeated exposure	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) This substance decomposes very rapidly in contact with water to produce calcium hydroxide (CAS RN 1305-62-0) and phosphine (synonym: hydrogen phosphide, CAS RN 7803-51-2) (CLH Report (2012)). (2) In the GHS classification project in FY2014, calcium hydroxide was classified as "Classification not possible" based on the following rationale. There are descriptions that chronic ingestion of this substance can result in inflammatory and ulcerous changes in the mouth and digestive tract by irritation (HSDB (Access on September 2014)), and that atrophic changes in the liver, kidney and stomach and inflammation in the small intestine were observed in a test in which rats were administered with drinking water for 3 months (IUCLID (2000)). However, details including the dose were unknown. (3) In the GHS classification project in FY2019, phosphine was classified as "Classification not possible" because there are no case reports, etc. of repeated exposure in humans, and no clear effects were observed in inhalation exposure studies in experimental animals at concentrations that allow repeated dose.
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information