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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	13067-93-1
Chemical Name	O-(4-Cyanophenyl) O-ethyl phenylphosphonothioate; Cyanofenphos
Substance ID	R01-B-119
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7	Flammable solids	*	- -	-	-	There is information that it is combustible (GESTIS (Access on October 2019)), but the classification is not possible due to no data.
8	Self-reactive substances and mixtures	*	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10	Pyrophoric solids	*	- -	-	-	No data available.
11	Self-heating substances and mixtures	*	- -	-	-	Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	*	- -	-	-	It contains a metalloid (P), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility data of 0.6 mg/L (30 deg C) (GESTIS (Access on October 2019)).
13	Oxidizing liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to an element (P) other than carbon or hydrogen. However, the classification is not possible due to no data.
15	Organic peroxides	*	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 2. [Evidence Data] (1) LD50 for rats: male: 89 mg/kg, female: 32 mg/kg (JMPR (1975)) (2) LD50 for rats: 89 mg/kg (IPCS, PIM G001 (1989)) (3) LD50 for rats: 28.5 mg/kg (GESTIS (Access on October 2019))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 3. The category was changed from the previous classification by using the new information sources. [Evidence Data] (1) LD50 for rats: male: >1,000 mg/kg, female: 640 mg/kg (JMPR (1975))
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
3	Serious eye damage/eye irritation	*	- -	-	-	[Rationale for the Classification] Although there are data in (1) and (2), these are insufficient data for classification, therefore, it was classified as "Classification not possible." [Reference Data, etc.] (1) In an eye irritation test in which 0.05 mL of a suspension of this substance in Tween 80 was administered to the eyes of rabbits, it was irritating at or above 0.2%, and congestion of the conjunctiva and lacrimation were observed at 1%, but no abnormalities were observed in the cornea, corneal reflex, conjunctival reflex and pupil diameter (JMPR (1975)). (2) It was classified as "Eye Irrit. 2 (H319)" in the EU-CLP classification (EU CLP classification (Access on October 2019)).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Although there are data in (1), these are insufficient data for classification, therefore, it was classified as "Classification not possible." [Reference Data, etc.] (1) No significant changes were observed in a skin sensitization test with guinea pigs (intradermal sensitization: 1% and 5% solutions of this substance every other day for 20 days, challenge by intradermal administration and topical application 14 days after the final sensitization) (JMPR (1975)).
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] There are no in vivo data, therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, negative results were reported in bacterial reverse mutation tests (JMPR (1980)).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (1), reproductive effects were observed over three generations, but the extent of the effects is unknown. Therefore, there is some evidence of reproductive toxicity, and it was classified in Category 2. The classification result was changed from the previous classification by the use of new information. [Evidence Data] (1) In a 3-generation reproductive toxicity test with rats dosed by feeding, reduced mating indices (third generation (F3): first parents (first generation) defined as F1), lowered male and female fertility (second generation (F2) and third generation (F3)), and reduced pup viability (unknown from which parental generation they were) were observed at the dose where no parental toxicity was observed (JMPR (1975)). [Reference Data, etc.] (2) In a developmental toxicity test with female rabbits administered by gavage on gestational Days 6-18, no developmental effects were observed (JMPR (1975)).
8	Specific target organ toxicity - Single exposure	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. Based on (1), the possibility of effects on the nervous system was considered. However, since there were no descriptions of acute toxicity symptoms from this substance in evaluation reports listed in List 1 or List 2, and a literature search did not provide information to support neurotoxicity by single exposure, therefore, it was classified as "Classification not possible." [Reference Data, etc.] (1) This substance is an organophosphorus pesticide. The mode of action of organophosphorus pesticides was described to be inhibition of acetylcholinesterase (IPCS, PIM G001 (1989)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (nervous system). After the review using the new information sources, the classification result was changed from the previous classification. [Evidence Data] (1) In a 12-month repeated dose toxicity test with dogs dosed by feeding, ataxia of the hindquarters, increased liver to body and brain weight ratio, and decreased plasma and red blood cell cholinesterase activities were observed at 100 ppm (converted guidance value: 2.5 mg/kg/day, within the range of Category 1) (JMPR (1975)). (2) In a 24-month repeated dose toxicity test with rats dosed by feeding, depressed plasma, red blood cell and brain cholinesterase activities were observed in females at or above 50 ppm (converted guidance value: 2.5 mg/kg/day, within the range of Category 1) and in males at or above 100 ppm (converted guidance value: 5 mg/kg/day, within the range of Category 1) (JMPR (1975)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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