NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	65405-77-8
Chemical Name	cis-3-Hexenyl salicylate
Substance ID	R02-A-010-METI, MOE
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	A flash point was 110 deg C (closed-cup) (GESTIS (Accessed June 2020)).
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (ethylenes) present in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 390 deg C (ECHA (Accessed June 2020)).
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" (Category 5 in UN GHS classification) from (1). [Evidence Data] (1) LD50 for rats: 5,000 mg/kg (REACH registration dossier (Accessed June 2020))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rabbits: > 5,000 mg/kg (REACH registration dossier (Accessed June 2020))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1) - (3). [Evidence Data] (1) It is reported that in a patch test in 50 persons, by induction by 3-week occlusive application of about 100 mg of a 15% solution of this substance and challenge by 48-hour occlusive application of about 100 mg an 8% solution at 14 days after induction, there were no skin reactions (REACH registration dossier (Accessed June 2020)). (2) It is reported that in a patch test in 25 persons, after 24-hour occlusive application of a 5% solution of sodium lauryl sulfate to the forearms followed by 48-hour application of this substance, no positive reactions were seen in any subject (REACH registration dossier (Accessed June 2020)). (3) It is reported that in a maximization test with guinea pigs (n = 20) (OECD TG 406, GLP, intradermal administration: 5% solution), a positive rate was 0% (0/20) at both 24 and 48 hours after removal of patches (REACH registration dossier (Accessed June 2020)).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Since there was no in vivo data, classification was not possible due to lack of data. [Evidence Data] (1) In a bacterial reverse mutation test, negative results were reported (JECDB (Accessed June 2020)). (2) In an in vitro mammalian cell (CHL/IU) chromosome aberration test, negative results were reported (JECDB (Accessed June 2020)).
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Since (1) was a screening test, the concern with respect to reproductive/developmental effects could not be ruled out. Therefore, classification was not possible due to lack of data. In (1), reproductive/developmental effects were observed at 360 mg/kg/day, but since the maternal death rate exceeded 10%, classification based on (1) was considered inappropriate. At the low and intermediate doses at which there were no general toxicity effects, no reproduction/developmental toxicity was observed, but there was no data on developmental toxicity. [Reference Data, etc.] (1) It was reported that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG422, GLP, for 14 days prior to mating and until the day before necropsy (for 42 days) (males), for 14 days prior to mating and until day 4 of lactation (for 41 to 49 days) (females)), at 360 mg/kg/day, general toxicity effects such as death of maternal rats (3/12 cases), reduced body weight gain, reduced food consumption, hematological effects (lower erythrocyte count, higher MCV/MCH/reticulocyte rates and prolonged APTT/PT (males), lower platelet count (females)), higher liver weights/higher AST/ALT (females) and reproductive effects (tendency of lower gestation index, prolonged gestation period, a lower number of implantation sites, tendency of a lower delivery index, tendency of a higher number of stillborn pups) were observed in parental rats, and a lower number of liveborn pups, increased external abnormalities (vestigial tail, complete rachischisis, exencephaly), reduced body weight gain after birth, and a lower viability index on postnatal day 4 were observed in pups (JECDB (Accessed June 2020)).
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. Classification was not possible based on (1) because the doses used in the test exceeded the range of Category 2. [Reference Data, etc.] (1) It was reported that in an acute dermal toxicity test with rabbits, skin irritation signs such as redness and edema were observed at 5,000 mg/kg (REACH registration dossier (Accessed June 2020)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (1), it was considered to be classified as "Not classified" in the oral route, but there was no information on toxicity in the other route. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) It was reported that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG422, GLP) (males: for 42 days, females: for 41 to 49 days), no effects were observed at the doses of up to 120 mg/kg/day (converted guidance value: 56 mg/kg/day (males), 54.7 mg/kg/day (females), within the range for Category 2), while death and lower body weight gain (pregnant females), hematological effects (anemic findings and prolonged coagulation time, mainly in males) and increased hepatogenic enzyme activities (males and females) were observed at 360 mg/kg/day (converted guidance value: 168 mg/kg/day (males), 164 mg/kg/day (females), in the range corresponding to "Not classified") (JECDB (Accessed June 2020)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour EC50 = 0.6 mg/L for crustacea (Daphnia magna) (REACH registration dossier, 2021).
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 because sufficient data on rapid degradability were not obtained and due to 72-hour NOErC = 0.15 mg/L for algae (Desmodesmus subspicatus) (REACH registration dossier, 2021). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 because sufficient data on rapid degradability were not obtained and due to 48-hour EC50 = 0.6 mg/L for crustacea (Daphnia magna) (REACH registration dossier, 2021). By drawing a comparison between the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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