NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	13189-00-9
Chemical Name	Zinc bismethacrylate
Substance ID	R02-A-011-METI
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Economy, Trade and Industry (METI)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available. Besides, there is information that it is combustible (GESTIS (Accessed Aug. 2020)).
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (ethylene group) present in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 377 deg C (ECHA (Accessed Aug. 2020)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metal (Zn), but it is estimated that it does not react vigorously with water from measured data: water solubility of 100 mg/L (20 deg C) (ECHA (Accessed Aug. 2020)).
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not classified	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to an element (Zn) other than carbon or hydrogen. However, because this is an ionic bond and does not contribute to oxidization, it was classified as "Not classified."
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] It was classified in Category 4 from (1). [Evidence Data] (1) LD50 for rats (females): 500 mg/kg (OECD TG423, GLP) (REACH registration dossier (Accessed Aug. 2020))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LC50 for rats (4 hours): > 5.23 mg/L (OECD TG436, GLP) (REACH registration dossier (Accessed Aug. 2020))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 7-day observation), erythema and edema were observed in one animal, which fully recovered after 7 days (erythema/eschar score: 2/0/0, edema score: 1.3/0/0) (REACH registration dossier (Accessed Aug. 2020)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] It was classified in Category 1 from (1). [Evidence Data] (1) It is reported that in an eye irritation test with a rabbit (n = 1) (OECD TG 405, GLP, 7-day observation), corneal opacity, iritis, and moderate conjunctival irrtation persisted for 7 days, and a miss-shaped cornea was seen (corneal opacity score: 2.3, iritis score: 1, conjunctival redness score: 2.7, chemosis score: 3) (REACH registration dossier (Accessed Aug. 2020)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Category 1A	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] It was classified in Category 1A from (1). [Evidence Data] (1) It is reported that in a maximization test with guinea pigs (n = 10) (OECD TG 406, GLP, intradermal administration: 0.2% solution), skin sensitization reactions were observed in 50%, 50%, 70% at 24, 48, 72 hours after challenge, respectively (REACH registration dossier (Accessed Aug. 2020)).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) In a bacterial reverse mutation test (OECD TG 476), negative results were reported (REACH registration dossier (Accessed Aug. 2020)). (2) In an in vitro mammalian cell gene mutation test (OECD TG 471), negative results were reported (REACH registration dossier (Accessed Aug. 2020)).
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) As for the classification results by domestic and international organizations, zinc and its compounds (CAS RN 7440-66-6) are classified in I (Inadequate information to assess carcinogenic potential) by the U.S. EPA (IRIS Summary (2005)). (2) Zinc compounds and methyl methacrylate are considered to have no carcinogenic potential. Therefore, it was considered that this substance was not classified as a carcinogen (REACH registration dossier (Accessed Aug. 2020)).
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	[Rationale for the Classification] It was judged that based on (1), the symptoms which were considered to be narcotic effects appeared in the oral route, and based on (2), respiratory effects due to respiratory tract mucosa irritation appeared in the inhalation route. Therefore, it was classified as Category 3 (narcotic effects, respiratory tract irritation). [Evidence Data] (1) It was reported that in an acute oral toxicity test with rats (OECD TG423, GLP), reduced spontaneous activities (6/6), a decrease of righting reflex (5/6) and piloerection (5/6) were observed from 30 minutes after administration at 300 mg/kg (within the range for Category 1), and all the treated rats died (3/3) at 2,000 mg/kg (within the range for Category 2) and mortalities were preceded by reduced spontaneous activities associated with decreased muscle tone, a decrease or absence of Preyer's and righting reflex, and piloerection (REACH registration dossier (Accessed Aug. 2020)). (2) It was reported that in an acute inhalation exposure test (dust, exposure to nose) with rats (OECD TG436, GLP, for 4 hours), 1/3 female rats died at 5.32 mg/L (in the range corresponding to "Not classified"). After exposure, all the rats exhibited increased respiratory rate, ataxia, and (in a few instances) noisy respiration which remained one hour post exposure. One day post exposure, all the rats exhibited hunched posture and piloerection. It was reported that the necropsy of the rats that died showed dark patches in the lungs and gaseous distension in the stomach, but the surviving rats showed no abnormalities (REACH registration dossier (Accessed Aug. 2020)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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