NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	32055-14-4
Chemical Name	Polymer of aniline / formaldehyde / phosgene
Substance ID	R02-A-012-METI, MOE
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. [Reference Data, etc.] (1) This substance (oligomeric MDI (Methylene diphenyl diisocyanate)) is a mixture consisting of 25-85% of 4,4'-MDI (CAS RN 101-68-8), the major constituent, 5-60% of higher oligomers (structurally close to PMDI (polymeric MDI)), 2,2'-MDI, 2,4'-MDI, and others (Document by the European trade association for producers of diisocyanates and polyols (Accessed Oct. 2020)).
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Classification not possible	- -	-	-	No data available.
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	[Rationale for the Classification] This substance was classified as a mixture consisting of >= 25% of 4,4'-MDI and >= 10% of PMDI from (1). It corresponds to "Not classified" by applying classification by the additivity formula in JIS Z7252:2019 from (2), (3), supposing that acute toxicity estimates (ATE) of 4,4'-MDI and PMDI, the constituents of this substance are > 10,000 mg/kg, and regarding that the toxicity of constituents whose ATE is unknown is equal to that of constituents whose ATE is known. However, because toxicity is unknown for 65% constituents of a mixture, and the contents of those with known ATE are low, the classification is not possible. [Evidence Data] (1) This substance (oligomeric MDI (Methylene diphenyl diisocyanate)) is a mixture containing 25-85% of 4,4'-MDI (CAS RN 101-68-8), the major constituent, 5-60% of higher oligomers (structurally close to PMDI (polymeric MDI)), 2,2'-MDI, 2,4'-MDI, and others (Document by the European trade association for producers of diisocyanates and polyols (Accessed Oct. 2020)). (2) LD50 for rats for 4,4'-MDI, >= 25% of which is contained in this substance: 31,600 mg/kg (CICAD 27 (2000)) (GHS classification result in FY2015). (3) LD50 for rats (males) for PMDI (structurally close to higher oligomers), >= 10% of which is contained in this substance: > 10,000 mg/kg (GHS classification result in FY2020)
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] It corresponds to "Not classified" by applying classification by the additivity formula in JIS Z7252:2019 from (1), (2), supposing that acute toxicity estimates (ATE) of PMDI, the constituent of this substance is > 9,400 mg/kg, and regarding that the toxicity of constituents whose ATE is unknown is equal to that of constituents whose ATE is known. However, because toxicity is unknown for 65% constituents of a mixture, and the contents of those with known ATE are low, the classification is not possible. [Evidence Data] (1) 4,4'-MDI, >= 25% of which is contained in this substance, was classified as "Classification not possible" for this hazard class (GHS classification result in FY2015). (2) LD50 for rabbits for PMDI (structurally close to higher oligomers), >= 10% of which is contained in this substance: > 9,400 mg/kg (GHS classification result in FY2020)
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	[Rationale for the Classification] It was classified in Category 2 by applying classification by the additivity formula in JIS Z7252:2019 from (1), (2), supposing that acute toxicity estimates (ATE) of 4,4'-MDI and PMDI, the constituents of this substance, is 0.05 mg/L, and regarding that the toxicity of constituents whose ATE is unknown is equal to that of constituents whose ATE is known. [Evidence Data] (1) 4,4'-MDI, >= 25% of which is contained in this substance, was classified in Category 2 for this hazard class (GHS classification result in FY2015). (2) PMDI (structurally close to higher oligomers), >= 10% of which is contained in this substance, was classified in Category 2 for this hazard class (GHS classification in FY2020)
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	[Rationale for the Classification] It was classified in Category 2 by applying the additivity formula in JIS Z7252:2019 from (1), (2). [Evidence Data] (1) 4,4'-MDI, >= 25% of which is contained in this substance, was classified in Category 2 for this hazard class (GHS classification in FY2015). (2) PMDI (structurally close to higher oligomers), >= 10% of which is contained in this substance, was classified as "Classification not possible" for this hazard class (GHS classification in FY2020).
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	[Rationale for the Classification] It was classified in Category 2 by applying the additivity formula in JIS Z7252:2019 from (1), (2). [Evidence Data] (1) 4,4'-MDI, >= 25% of which is contained in this substance, was classified in Category 2B for this hazard class (GHS classification in FY2015). (2) PMDI (structurally close to higher oligomers), >= 10% of which is contained in this substance, was classified in Category 2 for this hazard class (GHS classification in FY2020).
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	[Rationale for the Classification] It was classified in Category 1 by applying concentration limits in JIS Z7252:2019 from (1), (2). [Evidence Data] (1) 4,4'-MDI, >= 25% of which is contained in this substance, was classified in Category 1 for this hazard class (GHS classification in FY2015). (2) PMDI (structurally close to higher oligomers), >= 10% of which is contained in this substance, was classified in Category 1 for this hazard class (GHS classification in FY2020).
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] It was classified in Category 1 by applying concentration limits in JIS Z7252:2019 from (1), (2). [Evidence Data] (1) 4,4'-MDI, >= 25% of which is contained in this substance, was classified in Category 1 for this hazard class (GHS classification in FY2015). (2) PMDI (structurally close to higher oligomers), >= 10% of which is contained in this substance, was classified in Category 1 for this hazard class (GHS classification in FY2020).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) 4,4'-MDI which is an ingredient contained in this substance at 25% or higher was classified as "Classification not possible" for this hazard class in the GHS classification (GHS Classification Results in FY2015). (2) PMDI having a structure similar to that of higher oligomers which is an ingredient contained in this substance at 10% or higher was classified as "Classification not possible" for this hazard class in the GHS classification (GHS Classification Results in FY2020).
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 2, applying the concentration limits of JIS Z7252:2019. [Evidence Data] (1) 4,4'-MDI which is an ingredient contained in this substance at 25% or higher was classified as "Classification not possible" for this hazard class in the GHS classification (GHS Classification Results in FY2015). (2) PMDI having a structure similar to that of higher oligomers which is an ingredient contained in this substance at 10% or higher was classified in Category 2 for this hazard class in the GHS classification (GHS Classification Results in FY2020).
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) 4,4'-MDI which is an ingredient contained in this substance at 25% or higher was classified as "Classification not possible" for this hazard class in the GHS classification (GHS Classification Results in FY2015). (2) PMDI having a structure similar to that of higher oligomers which is an ingredient contained in this substance at 10% or higher was classified as "Classification not possible" for this hazard class in the GHS classification (GHS Classification Results in FY2020).
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (respiratory organs), applying the concentration limits of JIS Z7252:2019. [Evidence Data] (1) 4,4'-MDI which is an ingredient contained in this substance at 25% or higher was classified in Category 1 (respiratory organs) for this hazard class in the GHS classification (GHS Classification Results in FY2015). (2) PMDI having a structure similar to that of higher oligomers which is an ingredient contained in this substance at 10% or higher was classified in Category 1 (respiratory organs) for this hazard class in the GHS classification (GHS Classification Results in FY2020).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (respiratory organs), applying the concentration limits of JIS Z7252:2019. [Evidence Data] (1) 4,4'-MDI which is an ingredient contained in this substance at 25% or higher was classified in Category 1 (respiratory organs) for this hazard class in the GHS classification (GHS Classification Results in FY2015). (2) PMDI having a structure similar to that of higher oligomers which is an ingredient contained in this substance at 10% or higher was classified in Category 1 (respiratory organs) for this hazard class in the GHS classification (GHS Classification Results in FY2020).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information